Studies with 211At in Nude Mice Bearing Human Thyroid Tumor Xenografts

1992 ◽  
pp. 494-501
Author(s):  
I. Brown ◽  
R. N. Carpenter ◽  
K. Randle
Keyword(s):  
Nude Mice ◽  
Thyroid Tumor ◽  
Human Thyroid ◽  
Tumor Xenografts

Nude mice with lacZ transduced human tumor xenografts as an in vivo model for invasion and metastasis

Lung Cancer ◽  
1991 ◽  
Vol 7 ◽  
pp. 30 ◽  
Author(s):  
Mogens Spang-Thomsen ◽  
James A. Zwiebel ◽  
Jørgen Rygaard ◽  
Nils Brünner
Keyword(s):  
Nude Mice ◽  
Human Tumor ◽  
In Vivo Model ◽  
Invasion And Metastasis ◽  
Human Tumor Xenografts ◽  
Tumor Xenografts

Status and expression of thep16INK4 gene in human thyroid tumors and thyroid-tumor cell lines

1996 ◽  
Vol 67 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Viola Calabr� ◽  
Maria Strazzullo ◽  
Girolama La Mantia ◽  
Monica Fedele ◽  
Christian Paulin ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Thyroid Tumor ◽  
Human Thyroid ◽  
Thyroid Tumors ◽  
Tumor Cell Lines

Growth of human tumor xenografts in nude mice and mice with severe combined immunodeficiency (SCID)

Surgery Today ◽  
1993 ◽  
Vol 23 (4) ◽  
pp. 375-377 ◽  
Author(s):  
Tetsuro Kubota ◽  
Hiroshi Yamaguchi ◽  
Masahiko Watanabe ◽  
Takaaki Yamamoto ◽  
Tetsuya Takahara ◽  
...  
Keyword(s):  
Nude Mice ◽  
Severe Combined Immunodeficiency ◽  
Human Tumor ◽  
Combined Immunodeficiency ◽  
Human Tumor Xenografts ◽  
Tumor Xenografts

Ultrastructural morphology and evidence of iodide uptake and protein synthesis in normal human thyroid transplants in nude mice

1984 ◽  
Vol 7 (6) ◽  
pp. 569-578 ◽  
Author(s):  
S. Smeds ◽  
E. Jörtsö ◽  
B. Anderberg ◽  
B. Boeryd ◽  
L. E. Ericson ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Nude Mice ◽  
Human Thyroid ◽  
Iodide Uptake ◽  
Ultrastructural Morphology ◽  
Normal Human

Effects of Mitochondrial Ferritin Expression on Tumor Iron Metabolism and Tumor Growth in Nude Mice Xenografts.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3582-3582
Author(s):  
Guangjun Nie ◽  
Guohua Chen ◽  
Alex Sheftel ◽  
Kostas Pantopoulos ◽  
Prem Ponka
Keyword(s):  
Tumor Growth ◽  
Nude Mice ◽  
Iron Metabolism ◽  
Rna Binding ◽  
Heme Oxygenase 1 ◽  
Iron Starvation ◽  
Iron Storage ◽  
Iron Regulatory Proteins ◽  
Tumor Xenografts ◽  
Mitochondrial Iron

Abstract Mitochondrial ferritin (MtFt) is a mitochondrial iron storage protein, whose function and regulation is largely unknown. Our previous results have shown that MtFt markedly affects intracellular iron distribution and homeostasis in mammalian cells (Blood105: 2161–2167, 2005). Using tumor xenografts, we examined the effects of expression MtFt on tumor iron metabolism and growth. H1299 parental or MtFt overexpressing cells were implanted into nude mice. As compared to control tumor xenografts, the expression of MtFt dramatically reduced the implanted tumor growth. A cytosolic iron starvation phenotype in MtFt expressing tumors was revealed by increased RNA-binding activity of iron regulatory proteins (IRPs) and, concomitantly, both an increase in transferrin receptor levels and a decrease in cytosolic ferritin. MtFt overexpression also led to a decrease in both total cellular heme content and heme oxygenase-1 levels. In addition, the expression of MtFt in tumors was associated with a decrease in aconitase activity and lower frataxin protein levels. Mitochondrial iron deposition in MtFt expressing tumors was directly observed by transmission electron microscopy. The pattern of iron accumulation in MtFt overexpressing tumor cells is remarkably similar to that observed in the mitochondria of sideroblastic anemia patients. In conclusion, our study shows that MtFt expression significantly affected tumor iron homeostasis by shunting iron into mitochondria; iron scarcity resulted in partial defects in heme and iron-sulfur cluster syntheses. It is likely that deprivation of iron in the cytosol is the cause of the significant inhibition of xenograft tumor growth.

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