Effects of l a,25-Dihydroxyvitamin D3 on Compensatory Renal Growth in the Growing Rat

2015 ◽  
pp. 302-309
Author(s):  
S. Matthias ◽  
E. Ritz ◽  
G. Mall
Keyword(s):  
Renal Growth ◽  
Compensatory Renal Growth ◽  
Dihydroxyvitamin D3 ◽  
Growing Rat

scholarly journals Effects of 1,25(OH)2D3 on compensatory renal growth in the growing rat

1991 ◽  
Vol 40 (2) ◽  
pp. 212-218 ◽  
Author(s):  
Stephan Matthias ◽  
Reinhold Busch ◽  
Jürgen Merke ◽  
Gerhard Mall ◽  
Monique Thomasset ◽  
...  
Keyword(s):  
Renal Growth ◽  
Compensatory Renal Growth ◽  
Growing Rat

Early increase in pulsatile growth hormone release after unilateral nephrectomy in adult rats

1994 ◽  
Vol 266 (4) ◽  
pp. F628-F632 ◽  
Author(s):  
A. Haramati ◽  
M. D. Lumpkin ◽  
S. E. Mulroney
Keyword(s):  
Growth Hormone ◽  
Early Time ◽  
Peak Level ◽  
Unilateral Nephrectomy ◽  
Sham Operation ◽  
Renal Growth ◽  
Adult Rats ◽  
Compensatory Renal Growth ◽  
Jugular Veins ◽  
Hypertrophic Response

Removal of one kidney results, within days, in accelerated growth of the remaining kidney. However, the mechanisms that underlie this compensatory renal hypertrophic response, particularly in the early time period following nephrectomy, are not understood. In this study we tested the hypothesis that removal of one kidney leads to a change in the pulsatile release of growth hormone (GH), which facilitates compensatory renal growth. Adult Wistar rats were implanted with Silastic cannulas in jugular veins and underwent either unilateral nephrectomy (UNX) or sham operation. Plasma levels of GH were determined 24 and 48 h after sham operation or UNX. Blood samples were taken every 20 min over a 6-h period from conscious, unrestrained animals. Pulsatile GH release was markedly elevated 24 h after UNX in both the amplitude of the surges as well as in the duration of release. Peak GH levels after 24 h were three- to fourfold higher in UNX rats compared with sham controls (417 +/- 75 vs. 119 +/- 23 ng/ml, P < 0.05). However, this enhanced release of GH appeared to be of short duration and began declining by 48 h post-UNX (peak level of 227 +/- 37 ng/ml, P < 0.05 vs. both 24 h UNX and sham controls). To examine whether this rise in GH release post-UNX contributed to the compensatory renal growth, rats underwent UNX and were immediately treated with an antagonist to GH-releasing factor (GRF-AN; i.e., [N-Ac-Tyr1,D-Arg2]GRF-(1-29) amide, 200 micrograms/kg twice daily), and the effects on GH release and renal growth were determined. Administration of GRF-AN significantly suppressed the increase in GH release post-UNX and was associated with a significant attenuation in renal growth 48 h post-UNX in GRF-AN-treated rats (8.7 +/- 2.6% vs. 22.7 +/- 3.0% in UNX controls, P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

CT Evaluation of Compensatory Renal Growth in Relation to Postnephrectomy Time

1992 ◽  
Vol 33 (6) ◽  
pp. 566-568 ◽  
Author(s):  
P. Prassopoulos ◽  
N. Gourtsoyiannis ◽  
D. Cavouras ◽  
N. Pantelidis
Keyword(s):  
Renal Carcinoma ◽  
Compensatory Hypertrophy ◽  
Renal Parenchyma ◽  
Renal Growth ◽  
Compensatory Renal Growth ◽  
Kidney Size ◽  
Before And After ◽  
Ct Evaluation ◽  
Multiple Measurements ◽  
Parenchymal Thickness

In 27 patients nephrectoraized for renal carcinoma, the compensatory hypertrophy of the remaining kidney was assessed by 72 CT examinations performed one month before and during 32 months after nephrectomy. Kidney size was estimated on CT by multiple measurements of the renal parenchymal thickness. Kidney growth was evaluated by comparing the amount of renal parenchyma before and after contralateral nephrectomy. Renal compensatory hypertrophy varied with postnephrectomy time. Kidney enlargement was 15% in the first 3 months, reached maximum 30% about a year later, and was reduced to 5%, 2 1/2 years postoperatively.

scholarly journals Age-dependent characteristics of compensatory renal growth

1975 ◽  
Vol 8 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Joel M. Kaufman ◽  
Robert Hardy ◽  
John P. Hayslett
Keyword(s):  
Renal Growth ◽  
Compensatory Renal Growth ◽  
Age Dependent
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