Compensatory renal growth: Interactions of nephrectomy serum and urine antisera leading to a new theory of renal growth regulation

1987 ◽  
Vol 15 (1) ◽  
Author(s):  
B.W. Snow ◽  
W.F. Tarry ◽  
J.W. Duckett
Keyword(s):  
Growth Regulation ◽  
Renal Growth ◽  
Compensatory Renal Growth ◽  
Serum And Urine

Peritubular endothelial cell proliferation in mice during compensatory renal growth after unilateral nephrectomy

1993 ◽  
Vol 265 (5) ◽  
pp. F712-F716 ◽  
Author(s):  
S. Kanda ◽  
H. Hisamatsu ◽  
T. Igawa ◽  
J. Eguchi ◽  
M. Taide ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Growth Regulation ◽  
Significant Inhibition ◽  
Labeling Index ◽  
Unilateral Nephrectomy ◽  
Endothelial Cell Proliferation ◽  
Renal Growth ◽  
Compensatory Renal Growth ◽  
Inhibition Of Proliferation ◽  
Tubular Cells

The proliferation of peritubular endothelial cells during compensatory renal growth (CRG) following unilateral nephrectomy in mice was investigated using a labeling index. The labeling index of peritubular endothelial cells increased 6 h after uninephrectomy and decreased to the normal level within 72 h. Immunohistochemical study revealed that c-myc protein was expressed in the nuclei of both cortical tubular cells and peritubular endothelial cells. Furthermore, intravenous injection of anti-basic fibroblast growth factor (bFGF) neutralizing antibody just after uninephrectomy led to significant inhibition of proliferation of peritubular endothelial cells, but not tubular cells. These results indicate that peritubular endothelial cells proliferate transiently during CRG and that bFGF plays an important role for the growth regulation of that cell in the kidney.

Early increase in pulsatile growth hormone release after unilateral nephrectomy in adult rats

1994 ◽  
Vol 266 (4) ◽  
pp. F628-F632 ◽  
Author(s):  
A. Haramati ◽  
M. D. Lumpkin ◽  
S. E. Mulroney
Keyword(s):  
Growth Hormone ◽  
Early Time ◽  
Peak Level ◽  
Unilateral Nephrectomy ◽  
Sham Operation ◽  
Renal Growth ◽  
Adult Rats ◽  
Compensatory Renal Growth ◽  
Jugular Veins ◽  
Hypertrophic Response

Removal of one kidney results, within days, in accelerated growth of the remaining kidney. However, the mechanisms that underlie this compensatory renal hypertrophic response, particularly in the early time period following nephrectomy, are not understood. In this study we tested the hypothesis that removal of one kidney leads to a change in the pulsatile release of growth hormone (GH), which facilitates compensatory renal growth. Adult Wistar rats were implanted with Silastic cannulas in jugular veins and underwent either unilateral nephrectomy (UNX) or sham operation. Plasma levels of GH were determined 24 and 48 h after sham operation or UNX. Blood samples were taken every 20 min over a 6-h period from conscious, unrestrained animals. Pulsatile GH release was markedly elevated 24 h after UNX in both the amplitude of the surges as well as in the duration of release. Peak GH levels after 24 h were three- to fourfold higher in UNX rats compared with sham controls (417 +/- 75 vs. 119 +/- 23 ng/ml, P < 0.05). However, this enhanced release of GH appeared to be of short duration and began declining by 48 h post-UNX (peak level of 227 +/- 37 ng/ml, P < 0.05 vs. both 24 h UNX and sham controls). To examine whether this rise in GH release post-UNX contributed to the compensatory renal growth, rats underwent UNX and were immediately treated with an antagonist to GH-releasing factor (GRF-AN; i.e., [N-Ac-Tyr1,D-Arg2]GRF-(1-29) amide, 200 micrograms/kg twice daily), and the effects on GH release and renal growth were determined. Administration of GRF-AN significantly suppressed the increase in GH release post-UNX and was associated with a significant attenuation in renal growth 48 h post-UNX in GRF-AN-treated rats (8.7 +/- 2.6% vs. 22.7 +/- 3.0% in UNX controls, P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

CT Evaluation of Compensatory Renal Growth in Relation to Postnephrectomy Time

1992 ◽  
Vol 33 (6) ◽  
pp. 566-568 ◽  
Author(s):  
P. Prassopoulos ◽  
N. Gourtsoyiannis ◽  
D. Cavouras ◽  
N. Pantelidis
Keyword(s):  
Renal Carcinoma ◽  
Compensatory Hypertrophy ◽  
Renal Parenchyma ◽  
Renal Growth ◽  
Compensatory Renal Growth ◽  
Kidney Size ◽  
Before And After ◽  
Ct Evaluation ◽  
Multiple Measurements ◽  
Parenchymal Thickness

In 27 patients nephrectoraized for renal carcinoma, the compensatory hypertrophy of the remaining kidney was assessed by 72 CT examinations performed one month before and during 32 months after nephrectomy. Kidney size was estimated on CT by multiple measurements of the renal parenchymal thickness. Kidney growth was evaluated by comparing the amount of renal parenchyma before and after contralateral nephrectomy. Renal compensatory hypertrophy varied with postnephrectomy time. Kidney enlargement was 15% in the first 3 months, reached maximum 30% about a year later, and was reduced to 5%, 2 1/2 years postoperatively.

scholarly journals Age-dependent characteristics of compensatory renal growth

1975 ◽  
Vol 8 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Joel M. Kaufman ◽  
Robert Hardy ◽  
John P. Hayslett
Keyword(s):  
Renal Growth ◽  
Compensatory Renal Growth ◽  
Age Dependent

Effect of Treatment with Enalapril, Verapamil and Indomethacin on Compensatory Renal Growth in the Rat

1990 ◽  
Vol 5 (9) ◽  
pp. 777-780 ◽  
Author(s):  
J. P. Wight ◽  
A. H. Bassett ◽  
J. E. le Carpentier ◽  
A. M. El Nahas
Keyword(s):  
Renal Growth ◽  
Compensatory Renal Growth ◽  
Effect Of Treatment
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