Synergistic Antiproliferative Effects of TNF and IL-4 against Various Tumor Cell Lines

2015 ◽  
pp. 191-196
Author(s):  
Bharat B. Aggarwal ◽  
Klara Totpal
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Antiproliferative Effects

In vitro antiproliferative effects on human tumor cell lines of extracts from the Bangladeshi medicinal plant Aegle marmelos Correa

Phytomedicine ◽  
2003 ◽  
Vol 10 (4) ◽  
pp. 300-308 ◽  
Author(s):  
I. Lampronti ◽  
D. Martello ◽  
N. Bianchi ◽  
M. Borgatti ◽  
E. Lambertini ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Aegle Marmelos ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Antiproliferative Effects

Antiproliferative Effects of Two Amides, Piperine and Piplartine, from Piper Species

2005 ◽  
Vol 60 (7-8) ◽  
pp. 539-543 ◽  
Author(s):  
Daniel Pereira Bezerra ◽  
Cláudia Pessoa ◽  
Manoel Odorico de Moraes ◽  
Edilberto Rocha Silveira ◽  
Mary Anne Sousa Lima ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Sea Urchin ◽  
Mtt Assay ◽  
Brine Shrimp ◽  
Membrane Damage ◽  
Tumor Cell Lines ◽  
Antiproliferative Effects ◽  
Sea Urchin Eggs ◽  
Brine Shrimp Lethality Assay

The present work evaluated the cytotoxicity of piplartine {5,6-dihydro-1-[1-oxo-3-(3,4,5- trimethoxyphenyl)-trans-2-propenyl]-2(1H)pyridinone} and piperine {1-[5-(1,3)-benzodioxol- 5-yl)-1-oxo-2,4-pentadienyl]piperidine}, components obtained from Piper species. The substances were tested for their cytotoxicity on the brine shrimp lethality assay, sea urchin eggs development, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay using tumor cell lines and lytic activity on mouse erythrocytes. Piperine showed higher toxicity in brine shrimp (DL50 = 2.8 d 0.3 μg/ml) than piplartine (DL50 = 32.3 d 3.4 μg/ml). Both piplartine and piperine inhibited the sea urchin eggs development during all phases examined, first and third cleavage and blastulae, but in this assay piplartine was more potent than piperine. In the MTT assay, piplartine was the most active with IC50 values in the range of 0.7 to 1.7 μg/ml. None of the tested substances induced hemolysis of mouse erythrocytes, suggesting that the cytotoxicity of piplartine and piperine was not related to membrane damage.

scholarly journals New Dammarane-type Saponins from Gynostemma pentaphyllum

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1375 ◽  
Author(s):  
Po-Yen Chen ◽  
Chih-Chao Chang ◽  
Hui-Chi Huang ◽  
Li-Jie Zhang ◽  
Chia-Ching Liaw ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Gynostemma Pentaphyllum ◽  
Antiproliferative Effects ◽  
Aerial Parts

Six new dammarane-type saponins, gypenosides CP1-6 (16), along with 19 known compounds 7–25, were isolated and characterized from the aerial parts of Gynostemma pentaphyllum. Among these compounds, eight dammarane-type saponins, 2, 5, 6, 7, 11, 12, 13, and 15, exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2).

Systematic analysis of the antiproliferative effects of novel and standard anticancer agents in rhabdoid tumor cell lines

2010 ◽  
Vol 21 (5) ◽  
pp. 514-522 ◽  
Author(s):  
Henning Lünenbürger ◽  
Claudia Lanvers-Kaminsky ◽  
Birgit Lechtape ◽  
Michael C. Frühwald
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Anticancer Agents ◽  
Rhabdoid Tumor ◽  
Tumor Cell Lines ◽  
Systematic Analysis ◽  
Antiproliferative Effects

Analysis of the antiproliferative effects of 3-deazaneoplanocin A in combination with standard anticancer agents in rhabdoid tumor cell lines

2015 ◽  
Vol 26 (3) ◽  
pp. 301-311 ◽  
Author(s):  
Rebekka Unland ◽  
Christiane Borchardt ◽  
Dagmar Clemens ◽  
Marcel Kool ◽  
Uta Dirksen ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Anticancer Agents ◽  
Rhabdoid Tumor ◽  
Tumor Cell Lines ◽  
Antiproliferative Effects

Antiproliferative effects of petiveria alliacea on several tumor cell lines

1990 ◽  
Vol 22 ◽  
pp. 434 ◽  
Author(s):  
V. Rossi ◽  
L. Jovicevic ◽  
M.P. Troiani ◽  
M. Bonanomi ◽  
G. Mazzanti
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Antiproliferative Effects ◽  
Petiveria Alliacea

Interaction of Human Tumor Cells with Human Platelets and the Coagulation System

1983 ◽  
Vol 50 (03) ◽  
pp. 726-730 ◽  
Author(s):  
Hamid Al-Mondhiry ◽  
Virginia McGarvey ◽  
Kim Leitzel
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Cell Lines ◽  
Human Tumor ◽  
Human Platelets ◽  
Factor Vii ◽  
Coagulation System ◽  
Breast Adenocarcinoma ◽  
Activate Factor ◽  
Tumor Cell Lines

SummaryThis paper reports studies on the interaction between human platelets, the plasma coagulation system, and two human tumor cell lines grown in tissue culture: Melanoma and breast adenocarcinoma. The interaction was monitored through the use of 125I- labelled fibrinogen, which measures both thrombin activity generated by cell-plasma interaction and fibrin/fibrinogen binding to platelets and tumor cells. Each tumor cell line activates both the platelets and the coagulation system simultaneously resulting in the generation of thrombin or thrombin-like activity. The melanoma cells activate the coagulation system through “the extrinsic pathway” with a tissue factor-like effect on factor VII, but the breast tumor seems to activate factor X directly. Both tumor cell lines activate platelets to “make available” a platelet- derived procoagulant material necessary for the conversion of prothrombin to thrombin. The tumor-derived procoagulant activity and the platelet aggregating potential of cells do not seem to be inter-related, and they are not specific to malignant cells.

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