Potassium Channel Opening and Vasorelaxation

2015 ◽  
pp. 265-280 ◽  
Author(s):  
G. Siegel ◽  
J. Mironneau ◽  
F. Schnalke ◽  
G. Loirand ◽  
G. Stock
Keyword(s):  
Potassium Channel ◽  
Channel Opening

Effect of Testosterone on Potassium Channel Opening in Human Corporal Smooth Muscle Cells

2008 ◽  
Vol 5 (4) ◽  
pp. 822-832 ◽  
Author(s):  
Deok Hyun Han ◽  
Mee Ree Chae ◽  
Jae Hun Jung ◽  
Insuk So ◽  
Jong Kwan Park ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Potassium Channel ◽  
Muscle Cells ◽  
Channel Opening

Differential Modulation of the Cardiac Adenosine Triphosphate-sensitive Potassium Channel by Isoflurane and Halothane

2002 ◽  
Vol 97 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Wai-Meng Kwok ◽  
Anne T. Martinelli ◽  
Kazuhiro Fujimoto ◽  
Akihiro Suzuki ◽  
Anna Stadnicka ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Adenosine Triphosphate ◽  
Volatile Anesthetic ◽  
Volatile Anesthetics ◽  
Dependent Manner ◽  
Patch Clamp Technique ◽  
Channel Activation ◽  
Beneficial Effects ◽  
Channel Current ◽  
Channel Opening

Background The cardiac adenosine triphosphate-sensitive potassium (K(ATP)) channel is activated during pathophysiological episodes such as ischemia and hypoxia and may lead to beneficial effects on cardiac function. Studies of volatile anesthetic interactions with the cardiac K(ATP) channel have been limited. The goal of this study was to investigate the ability of volatile anesthetics halothane and isoflurane to modulate the cardiac sarcolemmal K(ATP) channel. Methods The K(ATP) channel current (I(KATP)) was monitored using the whole cell configuration of the patch clamp technique from single ventricular cardiac myocytes enzymatically isolated from guinea pig hearts. I(KATP) was elicited by extracellular application of the potassium channel openers 2,4-dinitrophenol or pinacidil. Results Volatile anesthetics modulated I(KATP) in an anesthetic-dependent manner. Isoflurane facilitated the opening of the K(ATP) channel. Following initial activation of I(KATP) by 2,4-dinitrophenol, isoflurane at 0.5 and 1.3 mm further increased current amplitude by 40.4 +/- 11.1% and 58.4 +/- 20.6%, respectively. Similar results of isoflurane were obtained when pinacidil was used to activate I(KATP). However, isoflurane alone was unable to elicit K(ATP) channel opening. In contrast, halothane inhibited I(KATP) elicited by 2,4-dinitrophenol by 50.6 +/- 5.8% and 72.1 +/- 11.6% at 0.4 and 1.0 mm, respectively. When I(KATP) was activated by pinacidil, halothane had no significant effect on the current. Conclusions The cardiac sarcolemmal K(ATP) channel is differentially modulated by volatile anesthetics. Isoflurane can facilitate the further opening of the K(ATP) channel following initial channel activation by 2,4-dinitrophenol or pinacidil. The effect of halothane was dependent on the method of channel activation, inhibiting I(KATP) activated by 2,4-dinitrophenol but not by pinacidil.

Synthesis and potassium KV7 channel opening activity of thioether analogues of the analgesic flupirtine

2018 ◽  
Vol 16 (45) ◽  
pp. 8695-8699 ◽  
Author(s):  
Christian Bock ◽  
Kristin Beirow ◽  
Abdrrahman S. Surur ◽  
Lukas Schulig ◽  
Anja Bodtke ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Oxidation Products ◽  
Potassium Channel Opener ◽  
Channel Opener ◽  
Channel Opening

Benign by design: active sulfide-analogues of potassium channel opener flupirtine do not form reactive oxidation products in vitro.

Testosterone Might Cause Relaxation of Human Corpus Cavernosum by Potassium Channel Opening Action

Urology ◽  
2009 ◽  
Vol 74 (1) ◽  
pp. 229-232 ◽  
Author(s):  
Oguzhan Yildiz ◽  
Melik Seyrek ◽  
Hasan Cem Irkilata ◽  
Ibrahim Yildirim ◽  
Lutfu Tahmaz ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Corpus Cavernosum ◽  
Channel Opening
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