Radiolabeled Monoclonal Antibodies for the Diagnosis and Treatment of Ovarian Carcinoma

2015 ◽  
pp. 228-239 ◽  
Author(s):  
Richard L. Wahl
Keyword(s):  
Monoclonal Antibodies ◽  
Ovarian Carcinoma ◽  
Diagnosis And Treatment

Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer

2020 ◽  
Vol 21 (11) ◽  
pp. 1097-1102
Author(s):  
Drashti Desai ◽  
Pravin Shende
Keyword(s):  
Breast Cancer ◽  
Monoclonal Antibodies ◽  
Diagnosis And Treatment ◽  
Detection Methods ◽  
Active Immunotherapy ◽  
Immune Checkpoints ◽  
Proliferation Index ◽  
Protein Fusion ◽  
Ki 67 ◽  
Cost Efficient

: Immunotherapy emerges as a treatment strategy for breast cancer marker, diagnosis and treatment. In this review, monoclonal antibodies (mAbs)-based passive and peptide vaccines as active immunotherapy approaches like activation of B-cells and T-cells are studied. Passive immunotherapy is mAbs-based therapy effective against tumor cells, which acts by targeting HER2, IGF 1R, VEGF, BCSC and immune checkpoints. Neuropeptide Y (NPY) and GPCR are the areas of interest to target BC metastases for on-targeting therapeutic action. Neuropeptide S (NPS) or NPS receptor 1, acts as a biomarker for Neuroendocrine tumors (NET), mostly characterized by synaptophysin and chromogranin-A expression or Ki-67 proliferation index. The protein fusion technologies arise as a promising avenue in plant expression systems for increased recombinant Ab accumulation and cost-efficient purification. Recently, mAbs-based immunotherapy effectiveness is appreciated as a novel therapeutic combination of chemotherapy and immunotherapy to reduce the side effects and improve therapeutic responsiveness. Synthetic drug resistance will be overcome by mAbs-based therapy through several clinical trials and detection methods need to be optimized for accuracy and precision. Pharmacokinetic attributes need to be accessed for preferred receptor-agonist activity without ligand accumulation.

A Double Determinant Radioimmunoassay Mov2-Mov8* for Monitoring Ovarian Carcinomas: Definition of the Methodology

1987 ◽  
Vol 2 (3) ◽  
pp. 161-168 ◽  
Author(s):  
Alessandro Diotti ◽  
Olivia Santoro ◽  
Liliana Mantovani ◽  
Mario Regazzoni ◽  
Rosanna Fontanelli ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Ovarian Carcinoma ◽  
Normal Population ◽  
Ovarian Carcinomas ◽  
Healthy Women ◽  
Circulating Antigens ◽  
Human Ovarian Carcinoma ◽  
Low Levels ◽  
Definition Of ◽  
Apparently Healthy

A double-determinant radioimmunoassay for the detection of circulating antigens associated with human ovarian carcinoma was developed using two monoclonal antibodies: MOv2 and MOv8 employed respectively as catcher and tracer. The development of the method through three different procedures enabled us to detect the presence of CaMOv2-CaMOv8 carrying molecules in 14 out of 15 ascitic fluids from ovarian carcinoma patients whose tumors were found to be positive with MOv2 and MOv8 monoclonal antibodies by immunofluorescence. Moreover, 13 out of 15 ovarian carcinoma patients presented high levels of antigen in their serum (60-170 Ua/ml). Low levels of antigen were observed in the normal population, the values ranging from 30-40 Ua/ml. However, in 13 out of 100 apparently healthy women high levels of antigen were found in the serum

Production of murine monoclonal antibodies against cell-surface antigens of human ovarian carcinoma

1985 ◽  
Vol 30 (4) ◽  
pp. 209-214 ◽  
Author(s):  
Malaya Bhattacharya ◽  
Sunil K. Chatterjee ◽  
Aniruddha Gangopadhyay ◽  
Joseph J. Barlow
Keyword(s):  
Monoclonal Antibodies ◽  
Cell Surface ◽  
Ovarian Carcinoma ◽  
Surface Antigens ◽  
Cell Surface Antigens ◽  
Human Ovarian Carcinoma ◽  
Murine Monoclonal Antibodies

Abstract 2857: Monoclonal antibodies against novel tumor markers for cancer diagnosis and treatment .

2013 ◽  
Author(s):  
Renata Maria Grifantini ◽  
Piero Pileri ◽  
Matteo Parri ◽  
Alberto Grandi ◽  
Susanna Campagnoli ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Tumor Markers ◽  
Cancer Diagnosis ◽  
Diagnosis And Treatment
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