Monoclonal antibodies: A potentially powerful tool in the diagnosis and treatment of infectious diseases

1985 ◽  
Vol 4 (3) ◽  
pp. 251-256 ◽  
Author(s):  
G. Spira ◽  
R. R. Pollock ◽  
A. Bargellesi ◽  
M. D. Scharff
Keyword(s):  
Monoclonal Antibodies ◽  
Infectious Diseases ◽  
Diagnosis And Treatment

Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer

2020 ◽  
Vol 21 (11) ◽  
pp. 1097-1102
Author(s):  
Drashti Desai ◽  
Pravin Shende
Keyword(s):  
Breast Cancer ◽  
Monoclonal Antibodies ◽  
Diagnosis And Treatment ◽  
Detection Methods ◽  
Active Immunotherapy ◽  
Immune Checkpoints ◽  
Proliferation Index ◽  
Protein Fusion ◽  
Ki 67 ◽  
Cost Efficient

: Immunotherapy emerges as a treatment strategy for breast cancer marker, diagnosis and treatment. In this review, monoclonal antibodies (mAbs)-based passive and peptide vaccines as active immunotherapy approaches like activation of B-cells and T-cells are studied. Passive immunotherapy is mAbs-based therapy effective against tumor cells, which acts by targeting HER2, IGF 1R, VEGF, BCSC and immune checkpoints. Neuropeptide Y (NPY) and GPCR are the areas of interest to target BC metastases for on-targeting therapeutic action. Neuropeptide S (NPS) or NPS receptor 1, acts as a biomarker for Neuroendocrine tumors (NET), mostly characterized by synaptophysin and chromogranin-A expression or Ki-67 proliferation index. The protein fusion technologies arise as a promising avenue in plant expression systems for increased recombinant Ab accumulation and cost-efficient purification. Recently, mAbs-based immunotherapy effectiveness is appreciated as a novel therapeutic combination of chemotherapy and immunotherapy to reduce the side effects and improve therapeutic responsiveness. Synthetic drug resistance will be overcome by mAbs-based therapy through several clinical trials and detection methods need to be optimized for accuracy and precision. Pharmacokinetic attributes need to be accessed for preferred receptor-agonist activity without ligand accumulation.

Functions and potential of lipocalin-2 as fecal biomarker for acute gastrointestinal infections (review of literature)

2021 ◽  
Vol 66 (6) ◽  
pp. 371-373
Author(s):  
Ekaterina Dmitrievna Lyutsova ◽  
M. D. Gospodinova ◽  
Y. D. Bocheva
Keyword(s):  
Infectious Diseases ◽  
Structure Function ◽  
Acute Diarrhea ◽  
Morbidity And Mortality ◽  
Diagnosis And Treatment ◽  
Lipocalin 2 ◽  
Review Of Literature ◽  
Gastrointestinal Infections ◽  
Non Invasive ◽  
Intestinal Infections

Despite the visible progress in reducing morbidity and mortality from intestinal infections and acute diarrhea associated with them, especially in childhood, the problem of their diagnosis and treatment remains relevant. The article discusses the structure, function and application of lipocalin-2 in infectious diseases as a non-invasive biomarker of bacterial inflammation in the intestine.

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