Acute Effect of Injected Growth Hormone on Glucose Metabolism in Normal Dogs

2015 ◽  
pp. 191-192
Author(s):  
N. Altszuler ◽  
D. Weinberg ◽  
B. Winkler
Keyword(s):  
Growth Hormone ◽  
Glucose Metabolism ◽  
Acute Effect

Effect of insulin on free fatty acid uptake by hepatocytes in the duck

1984 ◽  
Vol 102 (3) ◽  
pp. 381-386 ◽  
Author(s):  
R. Gross ◽  
P. Mialhe
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Glucose Metabolism ◽  
Free Fatty Acids ◽  
Fatty Acid Uptake ◽  
Acid Uptake ◽  
Low Doses ◽  
Higher Doses

ABSTRACT To elucidate the hypolipacidaemic effect of insulin in ducks, its action on the uptake of free fatty acids (FFA) by duck hepatocytes was determined. At low doses (10 mu./l) insulin stimulated FFA uptake. This effect was not observed with higher doses of insulin (20, 30 and 50 mu./l). Growth hormone at physiological concentrations and corticosterone (14·4 nmol/l) decreased basal activity, probably by reducing glucose metabolism and consequently α-glycerophosphate (α-GP) supply. Insulin was able to reverse the inhibition induced by GH and corticosterone on both FFA uptake and α-GP production. These results therefore suggest that the hypolipacidaemic effect of insulin may be partly mediated by its action on hepatic FFA uptake. J. Endocr. (1984) 102, 381–386

scholarly journals The acute effect of a physiological bolus of growth hormone (GH) on insulin signalling pathways in striated muscle in healthy volunteers

2009 ◽  
Vol 17 (Suppl 2) ◽  
pp. P3
Author(s):  
Thomas Krusenstjerna-Hafstrøm ◽  
Michael Madsen ◽  
Mikkel Vendelboe ◽  
Niels Jessen ◽  
Louise Møller ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Healthy Volunteers ◽  
Striated Muscle ◽  
Insulin Signalling ◽  
Acute Effect ◽  
Signalling Pathways

The acute effect of coffee on endothelial function and glucose metabolism following a glucose load in healthy human volunteers

2017 ◽  
Vol 8 (9) ◽  
pp. 3366-3373 ◽  
Author(s):  
Evan A. J. Boon ◽  
Kevin D. Croft ◽  
Sujata Shinde ◽  
Jonathan M. Hodgson ◽  
Natalie C. Ward
Keyword(s):  
Glucose Metabolism ◽  
Endothelial Function ◽  
Vascular Function ◽  
Acute Effect ◽  
Glucose Load ◽  
Healthy Human ◽  
Human Volunteers

The consumption of coffee, as a whole beverage, may improve vascular function, although this may be due to the caffeine.

scholarly journals Insulin action in growth hormone-deficient and age-matched control rats: effect of growth hormone treatment

1999 ◽  
Vol 160 (1) ◽  
pp. 127-135 ◽  
Author(s):  
◽  
JL Laustsen ◽  
BS Hansen ◽  
EA Richter
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Glucose Metabolism ◽  
Recombinant Human Growth Hormone ◽  
Normal Weight ◽  
Lower Amount ◽  
Control Group ◽  
Muscle Fibre Size ◽  
Igf I

The isolated effect of growth hormone on carbohydrate metabolism in rat skeletal muscle was studied in growth hormone-deficient dwarf rats (dw/dw) treated with either recombinant human growth hormone or saline for 10 days. In addition, age-matched heterozygous (DW/dw) (normal weight and plasma IGF-I) control rats were treated with saline. Growth hormone increased weight gain from 0.1+/-0.1 (s.e.m) to 3.6+/-0.1 g/day and plasma IGF-I concentration from 364+/-23 to 451+/-32 ng/ml. Glucose metabolism in skeletal muscle perfused with basal, submaximal and maximal concentrations (0, 600 and 60 000 pmol/l respectively) of insulin was not changed by growth hormone. No change could be detected in the total number of glucose transporters (GLUT1 and GLUT4) in the skeletal muscles, except from a lower amount of GLUT4 in the soleus muscle in the heterozygous control group. However, at submaximal insulin concentrations, skeletal muscle glucose uptake and transport were significantly lower in the heterozygous control group compared with the growth hormone-deficient group. This could indicate either a direct long-term effect of growth hormone or more likely a secondary effect attributable to the difference in body weight (205.2+/-3.1 vs 361. 6+/-5.9 g for dwarf rats and heterozygous controls respectively), and thereby muscle fibre size, between the groups probably resulting in lower average interstitial insulin and glucose concentrations at a given plasma concentration in the heterozygous rats. It is concluded that restoration of subnormal growth hormone concentrations for 10 days has no effect on insulin-stimulated glucose metabolism in skeletal muscle in vitro.

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