Tumor Immunotherapy by Local Injection of Interleukin 2 and Non-Reactive Lymphocytes

2015 ◽  
pp. 187-212 ◽  
Author(s):  
Guido Forni ◽  
Giovanni P. Cavallo ◽  
Mirella Giovarelli ◽  
Gabriella Benetton ◽  
Cristina Jemma ◽  
...  
Keyword(s):  
Interleukin 2 ◽  
Tumor Immunotherapy ◽  
Local Injection ◽  
Reactive Lymphocytes

scholarly journals Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen.

1993 ◽  
Vol 177 (5) ◽  
pp. 1517-1521 ◽  
Author(s):  
B Rocha ◽  
C Tanchot ◽  
H Von Boehmer
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Interleukin 2 ◽  
Cell Receptor ◽  
Immunological Tolerance ◽  
Receptor Ligands ◽  
In Vivo Growth ◽  
Reactive Lymphocytes ◽  
Clonal Anergy

Experiments in various models have indicated that immunological tolerance can result from the physical elimination (deletion) of reactive lymphocytes as well as from anergy. We have previously reported that mature CD4-CD8+ T cells when confronted with their antigen can proliferate extensively but are finally eliminated or become intrinsically anergic such that remaining cells are refractory to stimulation by any T cell receptor ligands, even in the presence of exogenous interleukin 2. Here we show that in vivo the anergy can be reversed in the absence of antigen, such that the cells are then able to proliferate extensively in vivo to a new challenge with the antigen in question.

Inhibition of growth of rat hepatoma by local injection of liposomes containing recombinant interleukin-2

Biotherapy ◽  
1991 ◽  
Vol 3 (3) ◽  
pp. 211-218 ◽  
Author(s):  
Hiroyuki Konno ◽  
Akira Yamashita ◽  
Takushi Tadakuma ◽  
Shukichi Sakaguchi
Keyword(s):  
Interleukin 2 ◽  
Local Injection ◽  
Inhibition Of Growth ◽  
Recombinant Interleukin 2 ◽  
Rat Hepatoma

The Antitumor Effect Induced by Local Injections with Interleukin-2 is Diminished by Combing with a Local Injection with Mitomycin C

1996 ◽  
Vol 18 (4) ◽  
pp. 497-509
Author(s):  
Teili Li ◽  
Mamoru Harada ◽  
Koji Tamada ◽  
Koichiro Abe ◽  
Osamu Ito ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Antitumor Effect ◽  
Interleukin 2 ◽  
Local Injection ◽  
Local Injections
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