Inhibition of growth of rat hepatoma by local injection of liposomes containing recombinant interleukin-2

Biotherapy ◽  
1991 ◽  
Vol 3 (3) ◽  
pp. 211-218 ◽  
Author(s):  
Hiroyuki Konno ◽  
Akira Yamashita ◽  
Takushi Tadakuma ◽  
Shukichi Sakaguchi
Keyword(s):  
Interleukin 2 ◽  
Local Injection ◽  
Inhibition Of Growth ◽  
Recombinant Interleukin 2 ◽  
Rat Hepatoma

scholarly journals Low molecular weight B-cell growth factor and recombinant interleukin-2 are together able to generate cytotoxic T lymphocytes with LAK activity from the bone marrow cells of children with acute lymphoblastic leukemia

Blood ◽  
1989 ◽  
Vol 74 (4) ◽  
pp. 1355-1359 ◽  
Author(s):  
MX Zhou ◽  
HW Jr Findley ◽  
AH Ragab
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Growth Factor ◽  
Cytotoxic T Lymphocytes ◽  
Lymphoblastic Leukemia ◽  
Interleukin 2 ◽  
Leukemic Cells ◽  
Recombinant Interleukin 2 ◽  
B Cell Growth Factor ◽  
Lak Activity

Abstract We are reporting here that low-mol wt B-cell growth factor (LMW-BCGF) and recombinant interleukin-2 (rIL-2) are together able to induce CD3+ cytotoxic T lymphocytes (CTL) with lymphokine-activated killer cell (LAK) activity from the bone marrow (BM) cells of children with acute lymphoblastic leukemia (ALL). Ficoll-Hypaque (FH)-separated BM cells were obtained from patients with active disease (at diagnosis N = 13, in relapse N = 15) and in complete remission (CR; N = 12). CD3+ cells were removed by Leu-4 antibody and immunobeads. Cells were cultured (10(5) cells/mL) in semisolid media with rIL-2 (100 mu/mL), LMW-BCGF (0.1 mu/mL), and the combination of rIL-2 plus LMW-BCGF, respectively, for seven to ten days. Pooled colonies were harvested for phenotyping. LMW-BCGF plus rIL-2 induced large numbers of CD3+ colonies from CD3- precursors. rIL-2 alone did not induce colony formation. In addition, cells were cultured in liquid media with LMW-BCGF, rIL-2, and the combination of LMW-BCGF plus rIL-2, respectively, for seven to 21 days. They were harvested for phenotyping, and cytotoxicity assays were performed v K562, Raji, and autologous leukemic cells. LMW-BCGF plus rIL-2 induced significant expansion of CD3+ cells from CD3- precursors, and these cells were activated to kill autologous leukemic cells in addition to Raji and K562 cell lines. LMW-BCGF or rIL-2 alone did not induce significant expansion or activation of cytotoxic CD3- cells. Our hypothesis is that LMW-BCGF plus rIL-2 stimulates the proliferation and activation of CD3- precursors from the BM cells of children with acute leukemia to become CD3+ cells that have LAK activity. This finding may have therapeutic implications.

Immunologic study of human recombinant interleukin-2 (low dose) in patients with advanced renal cell carcinoma

Urology ◽  
1989 ◽  
Vol 33 (3) ◽  
pp. 219-225 ◽  
Author(s):  
Ken Marumo ◽  
Junro Muraki ◽  
Munehisa Ueno ◽  
Masaaki Tachibana ◽  
Nobuhiro Deguchi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Low Dose ◽  
Interleukin 2 ◽  
Advanced Renal Cell Carcinoma ◽  
Recombinant Interleukin 2

Reevaluation of the Superiority of Polyethylene GlycolModified Interleukin-2 Over Regular Recombinant Interleukin-2

1995 ◽  
Vol 15 (7) ◽  
pp. 641-645 ◽  
Author(s):  
MONIQUE R. BERNSEN ◽  
HUB F.J. DULLENS ◽  
WILLEM DEN OTTER ◽  
A. PETER M. HEINTZ
Keyword(s):  
Interleukin 2 ◽  
Recombinant Interleukin 2

Subcutaneous Recombinant Interleukin-2 and a-Interferon in Patients with Advanced Renal Cell Carcinoma: Results of a Multicenter Phase II Study

1993 ◽  
Vol 8 (4) ◽  
pp. 289-300 ◽  
Author(s):  
Jens Atzpodien ◽  
Hartmut Kirchner ◽  
Peter de Mulder ◽  
Heiner Bodenstein ◽  
Tim Olivera ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Phase Ii ◽  
Renal Cell ◽  
Phase Ii Study ◽  
Interleukin 2 ◽  
Advanced Renal Cell Carcinoma ◽  
Multicenter Phase ◽  
Recombinant Interleukin 2

Use of Recombinant Interleukin-2 for Intrapleural Therapy of Tumor-Associated Pleurisy

2009 ◽  
Vol 148 (5) ◽  
pp. 794-796 ◽  
Author(s):  
K. S. Titov ◽  
M. V. Kiselevskii ◽  
L. V. Demidov ◽  
I. N. Mikhailova ◽  
I. Zh. Shubina ◽  
...  
Keyword(s):  
Interleukin 2 ◽  
Recombinant Interleukin 2
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