Vascular Effects of Captopril and Dihydralazine in Spontaneously Hypertensive Rats

2015 ◽  
pp. 142-151 ◽  
Author(s):  
J. L. Freslon ◽  
J. F. Giudicelli
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Vascular Effects ◽  
Spontaneously Hypertensive

Cardiac and Vascular Effects of Long-term Losartan Treatment in Stroke-Prone Spontaneously Hypertensive Rats

Hypertension ◽  
1996 ◽  
Vol 28 (3) ◽  
pp. 397-402 ◽  
Author(s):  
Peter Gohlke ◽  
Wolfgang Linz ◽  
Bernward A. Schölkens ◽  
Gabriele Wiemer ◽  
Thomas Unger
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Vascular Effects ◽  
Spontaneously Hypertensive ◽  
Losartan Treatment

Voluntary physical exercise-induced vascular effects in spontaneously hypertensive rats

2004 ◽  
Vol 107 (6) ◽  
pp. 571-581 ◽  
Author(s):  
Ulrika HÄGG ◽  
Irene ANDERSSON ◽  
Andrew S. NAYLOR ◽  
Julia GRÖNROS ◽  
Ingibjörg H. JONSDOTTIR ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Exercise ◽  
Vascular Function ◽  
Spontaneously Hypertensive Rats ◽  
Aortic Wall ◽  
Hypertensive Rats ◽  
Vascular Effects ◽  
Spontaneously Hypertensive ◽  
Wall Stiffness ◽  
Vascular Beds

Forced training has been shown to have beneficial vascular effects in various animal exercise models. In the present study, we explored possible physiological and molecular effects of voluntary physical exercise on various vascular beds. SHR (spontaneously hypertensive rats) performed voluntary exercise for 5 weeks in a computerized wheel cage facility. Ex vivo myograph studies revealed an increased sensitivity of the ACh (acetylcholine)-mediated vasodilation in resistance arteries of the exercised animals (ED50=15.0±3.5 nmol/l) compared with the controls (ED50=37.0±8.8 nmol/l; P=0.05). The exercise/control difference was abolished after scavenging reactive oxygen radicals. In conduit arteries, ACh induced a similar vasodilatory response in both groups. The in vivo aortic wall stiffness, assessed by means of Doppler tissue echography, was significantly lower in the exercising animals than in controls. This was demonstrated by significantly increased peak systolic aortic wall velocity (P=0.03) and the velocity time integral (P=0.01) in exercising animals compared with controls. The relative gene expression of eNOS (endothelial nitric oxide synthase) was similar in both groups of animals, whereas Cu/ZnSOD (copper/zinc superoxide dismutase) gene expression was significantly increased (+111%; P=0.0007) in the exercising animal compared with controls. In conclusion, voluntary physical exercise differentially improves vascular function in various vascular beds. Increased vascular compliance and antioxidative capacity may contribute to the atheroprotective effects associated with physical exercise in conduit vessels.

Biomembrane Characteristics in Stroke-prone Spontaneously Hypertensive Rats (SHRSP)

1978 ◽  
Vol 19 (4) ◽  
pp. 597-598 ◽  
Author(s):  
Yukio YAMORI ◽  
Yasuo NARA ◽  
Ryoichi HORIE ◽  
Michiya OHTAKA ◽  
Kiyoe OHTA ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive
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