Neutrophil Chemotactic Activity in the Late Phase Bronchial Obstruction

2015 ◽  
pp. 307-314 ◽  
Author(s):  
T. H. Lee ◽  
S. R. Durharn ◽  
T. Nagakura ◽  
Y. Iikura ◽  
A. B. Kay
Keyword(s):  
Late Phase ◽  
Chemotactic Activity ◽  
Bronchial Obstruction ◽  
Neutrophil Chemotactic Activity

Neutrophil chemotaxis, random migration, and adherence in patients with hyperthyroidism

1989 ◽  
Vol 121 (6) ◽  
pp. 817-820 ◽  
Author(s):  
B. Wolach ◽  
B. Lebanon ◽  
A. Jedeikin ◽  
M. S. Shapiro ◽  
L. Shenkman
Keyword(s):  
Thyroid Function ◽  
Chemotactic Activity ◽  
Neutrophil Chemotaxis ◽  
Phagocytic Cells ◽  
Random Migration ◽  
Significant Difference ◽  
Neutrophil Adherence ◽  
Hyperthyroid Patients ◽  
Normal Controls ◽  
Neutrophil Chemotactic Activity

Abstract. We have examined neutrophil adherence, chemotactic activity, and random migration in 35 hyperthyroid patients with Graves' disease and 106 normal volunteers. No statistically significant differences were found between granulocyte adherence of 17 hyperthyroid subjects (67 ± 15.6%) and 81 healthy volunteers (63.1 ± 17%). In 3 thyrotoxic patients, impaired neutrophil adherence was found, which resolved when thyroid function returned to normal. The neutrophil chemotactic activity of 32 normal controls was 107.5 ± 21.4 cells, and the random migration 36 ± 15.5 cells. No statistically significant difference was demonstrated in 13 hyperthyroid patients who had a neutrophil chemotactic activity of 102 ± 14.6 cells and a random migration of 31.2 ± 13.2 cells. Defective chemotactic activity and random migration was found in 2 patients. Neutrophil functions returned to normal in one of the two subjects who were re-evaluated when thyroid function recovered. In summary, 14% of hyperthyroid patients had impaired leukocyte functions. However, severe pyogenic infections are quite rare in hyperthyroid patients, indicating that the observed alterations in function of phagocytic cells are not clinically important.

Circulating Histamine and Neutrophil Chemotactic Activity During Allergen-Induced Asthma: The Effect of Inhaled Antihistamines and Anti-Allergic Compounds

1985 ◽  
Vol 69 (1) ◽  
pp. 63-69 ◽  
Author(s):  
D. J. R. Morgan ◽  
I. Moodley ◽  
D. R. Cundell ◽  
B. D. Sheinman ◽  
W. Smart ◽  
...  
Keyword(s):  
Airflow Obstruction ◽  
Isotonic Saline ◽  
Forced Expiratory Volume ◽  
Chemotactic Activity ◽  
Boyden Chamber ◽  
Plasma Histamine ◽  
Double Blind ◽  
Provocation Testing ◽  
Bronchial Provocation ◽  
Neutrophil Chemotactic Activity

1. Plasma histamine and serum neutrophil chemotactic activity (S-NCA) were measured in ten atopic asthmatic patients on four separate occasions after allergen bronchial provocation testing (BPT). 2. Single doses of inhaled sodium cromoglycate (SCG; 20 mg), clemastine (0.5 mg), ketotifen (0.5 mg) and isotonic saline (0.9% NaCl) placebo were administered 30 min before bronchial provocation testing in random order and double-blind. 3. The airflow obstruction after BPT was monitored by measurement of forced expiratory volume in 1s (FEV1). Plasma histamine was measured by the double-isotope radioenzymatic assay and S-NCA by a modified Boyden chamber technique. 4. A highly significant decrease in FEV1 after BPT occurred on the placebo pre-treatment visit (P < 0.001). Prior administration of inhaled SCG, clemastine and ketotifen significantly reduced the decrease in airflow obstruction seen after BPT when compared with placebo treatment (P < 0.01, P < 0.02, P < 0.05 respectively). 5. No significant alteration in plasma histamine was detected during allergen-induced airflow obstruction. 6. Levels of S-NCA were significantly higher 5, 10 and 15 min after BPT when compared with the pre-challenge level (P < 0.01, P < 0.01, P < 0.001 respectively). These levels were not significantly decreased when airflow obstruction was inhibited by the prior inhalation of SCG, clemastine or ketotifen.

In Vitro and in Vivo Antigen-Induced Release of High-Molecular Weight Neutrophil Chemotactic Activity from Human Nasal Tissue

1988 ◽  
Vol 2 (1) ◽  
pp. 7-11 ◽  
Author(s):  
T. Nagakura ◽  
T. Onda ◽  
Y. likura ◽  
T. Endo ◽  
H. Nagakura ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Nasal Polyps ◽  
Gel Filtration ◽  
Chemotactic Activity ◽  
Nasal Tissue ◽  
Nasal Secretions ◽  
Neutrophil Chemotactic Activity

High molecular weight neutrophil chemotactic activity has been identified in resected human nasal polyps, inferior turbinates, and nasal secretions following antigen challenge. The estimated molecular weight, by gel filtration chromatography, was approximately 600,000. However, a heterogeneity of molecular weight in some patients was recognized. Our results suggest a possible role for high molecular weight-neutrophil chemotactic activity in the pathogenesis of hypersensitivity in the human nasal cavity.

Neutrophil Chemotactic Activity of Sputum From Patients With COPD

CHEST Journal ◽  
2003 ◽  
Vol 123 (4) ◽  
pp. 1240-1247 ◽  
Author(s):  
Kai M. Beeh ◽  
Oliver Kornmann ◽  
Roland Buhl ◽  
Sarah V. Culpitt ◽  
Mark A. Giembycz ◽  
...  
Keyword(s):  
Chemotactic Activity ◽  
Neutrophil Chemotactic Activity

Exercise-induced asthma and the generation of neutrophil chemotactic activity

1990 ◽  
Vol 85 (2) ◽  
pp. 498-504 ◽  
Author(s):  
Per Venge ◽  
Jörn Henriksen ◽  
Ronald Dahl ◽  
Lena Håkansson
Keyword(s):  
Chemotactic Activity ◽  
Exercise Induced ◽  
Neutrophil Chemotactic Activity
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