69 Total Immunoglobulin E (IgE) Serum Levels: A Chronobiologic Approach

2015 ◽  
pp. 395-398
Author(s):  
V De Leonardis ◽  
M L Brandi
Keyword(s):  
Immunoglobulin E ◽  
Serum Levels ◽  
Total Immunoglobulin

Evaluation of Serum Total Immunoglobulin E, Interleukin-17 and Pentraxin-3 as Biomarkers for Chronic Rhinosinusitis With Nasal Polyposis

2020 ◽  
pp. 194589242098378
Author(s):  
Hossam A. Hussien ◽  
Mona S. Habieb ◽  
Ahmad M. Hamdan
Keyword(s):  
Chronic Rhinosinusitis ◽  
Sensitivity And Specificity ◽  
Nasal Polyposis ◽  
Immunoglobulin E ◽  
Serum Levels ◽  
Control Group ◽  
Interleukin 17 ◽  
Pentraxin 3 ◽  
Snot 22 ◽  
Total Immunoglobulin

Background Different biomarkers are detectable in cases of chronic rhinosinusitis with nasal polyposis (CRSwNP) with need for evaluation of their diagnostic and prognostic roles. Objective To assess the serum levels of total IgE, interleukin-17 and Pentraxin-3 in patients with CRSwNP and correlate them with the clinical evaluation using Sino-Nasal Outcome Test (SNOT-22), radiological evaluation using Lund – Mackay (LM) computed tomography scan score, and polyposis recurrence. Methods This cross-sectional comparative study was carried out on fifty patients with CRSwNP and twenty-five age and gender matched healthy volunteers as control group. Patients were assessed clinically by SNOT-22 and radiologically by LM score. Blood samples of patients and controls were analyzed for serum levels of total immunoglobulin E (IgE), Interleukin-17 (IL-17) and Pentraxin-3 (PTX-3). The correlation between the serum levels of every two markers of the study markers was assessed. The levels of the three biomarkers were correlated with SNOT-22 and LM scores and polyp recurrence with assessment of their sensitivity and specificity to diagnose CRSwNP. Results This study showed significantly higher values of the three biomarkers in patients group compared with control group (p < 0.001 for all). There were significant positive correlations between the levels of the three markers and SNOT 22 and LM scores (p < 0.001 for all) and with recurrence of polyposis (p < 0.001, p = 0.005 and p = 0.032 respectively). Agreement (sensitivity and specificity) for these markers to diagnose patient group was statistically significant (p < 0.001 for all). There was a significant positive correlation between every two markers of the study markers. Conclusion Serum levels of total IgE, IL-17 and PTX-3 are important biological markers for diagnosis and follow up of cases of CRSwNP with high sensitivity and specificity in detection of such cases. They should be included in the routine laboratory workup for cases of CRSwNP.

scholarly journals The Study of a Possible Correlation between Serum Levels of Interleukin 17 and Clinical Severity in Patients with Allergic Rhinitis

2017 ◽  
Vol 8 (3) ◽  
pp. ar.2017.8.0207
Author(s):  
Mai Aly Gharib Aly ◽  
Mohamed Tawfik El Tabbakh ◽  
Waheed Fawzy Heissam ◽  
Said Hamed Abbadi
Keyword(s):  
Allergic Rhinitis ◽  
Immunoglobulin E ◽  
Skin Testing ◽  
Allergic Diseases ◽  
Serum Levels ◽  
Clinical Severity ◽  
Total Serum ◽  
Interleukin 17 ◽  
Serum Ige ◽  
Cluster Immunotherapy

Introduction Allergic rhinitis (AR) is one of the most common allergic diseases, which affects ~20% of the world's population. T-helper (Th) type 2 cells produce interleukin (IL) 4 and IL-13, and mediate allergic responses, and these cytokines have been extensively studied as key players in the atopic airway diseases. However, the involvement of Th17 cells and IL-17 in AR has not been clearly examined. Aim To reevaluate AR clinical severity with serum IL-17, whether IL-17 affects the disease alone or in contribution with the atopic predisposition. Patients and Methods During an 18-month period, 39 individuals were divided into three groups: A, (13 control), B (13 with mild-to-moderate AR), and C (13 with severe AR). Both group B and group C patients (26) were subjected to clinical examination and allergy skin testing, and to measurement of both total serum immunoglobulin E (IgE) and IL-17 levels. Eleven patients with AR then were exposed to 6 months of cluster immunotherapy, whereas the rest of the patients were not exposed. Results Revealed a significant elevation of serum IL-17 levels with an associated increase in serum IgE in the patients with AR compared with controls and revealed that the serum levels of both total serum IgE and IL-17 decreased significantly after cluster immunotherapy. Conclusion These preliminary results added new data about the use of injective immunotherapy as well as reported on the use of sublingual immunotherapy.

Immunoglobulin E in Chronic Middle Ear Effusions

1976 ◽  
Vol 85 (2_suppl) ◽  
pp. 117-123 ◽  
Author(s):  
David J. Lim ◽  
Yea S. Liu ◽  
James Schram ◽  
Herbert G. Birck
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Middle Ear ◽  
Immunoglobulin E ◽  
Chronic Otitis Media ◽  
Serum Levels ◽  
Mast Cell Degranulation ◽  
Biopsy Specimens ◽  
History Of ◽  
Reaginic Antibody

A total of 61 middle ear effusions and matched sera obtained from patients suffering from chronic otitis media with effusions (OME) was examined for IgE and other immunoglobulins to see if a reaginic antibody is involved in OME. The IgE levels were determined by the Phadebas IgE radioimmunoassay test. Excluding one patient who had extremely high IgE as a result of parasitosis, there were only three cases which showed marginally increased serum IgE levels. Elevated IgE levels in sera and/or in effusions were unrelated to a history of allergy. The mucoid effusions had significantly higher effusion levels than the levels in corresponding sera (p <.0005). Fourteen percent of the cases examined showed effusion IgE levels five times or more higher than serum levels. Biopsy specimens of these patients showed numerous degranulating mast cells. Only two specimens showed eosinophilic infiltration. It is suggested that the IgE is produced locally by the mucosa in mucoid-type effusions and may have been involved in mast cell degranulation. However, this study cannot confirm the allergic nature of the OME.

Assessment of serum levels of allergen-specific immunoglobulin E in different seasons and breeds in healthy horses

2014 ◽  
Vol 17 (2) ◽  
pp. 331-337 ◽  
Author(s):  
P.M. Wilkołek ◽  
Z.J.H. Pomorski ◽  
M.P. Szczepanik ◽  
Ł. Adamek ◽  
M. Pluta ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Winter Season ◽  
Allergic Diseases ◽  
Serum Levels ◽  
Specific Ige ◽  
Diagnostic Tools ◽  
Storage Mites ◽  
Acarus Siro ◽  
Different Seasons ◽  
Domestic Mites

Abstract The present study was designed to asses specific IgE towards environment allergens in 42 healthy horses. Determination of this immunoglobulin in serum serve as diagnostic tools in allergic diseases to improve efficacy of the treatment and proper allergen selection to specific immunotherapy. Serum levels of allergen specific IgE were measured with equine monoclonal antibody, using 15 individual and 5 mix allergens in North European Panel. The study revealed season dependent increased levels of allergen specific IgE in normal horses. It is noteworthy that healthy horses show high percentage of positive reactions, most commonly towards to domestic mites D. farinae (80%), D. pteronyssinus (35.71%) and storage mites T. putrenscentiae (42.86%), Acarus siro (40.48%). These allergens play an important role in equine, canine and feline atopic dermatitis. We also demonstrated high IgE levels in the group of horse specific insect allergens. Tabanus sp. (35.71%), Culicoides sp. (28.57%) and Simulium sp. (26.19%) were the most frequent insect positive reaction allergens. No positive reactions in all groups of allergens were found in winter season, low and merely detectable levels of antibodies have been found relating to D. farianae and T. putrescentiae allergen. We observed elevated mould-IgE levels in horses that live in stables, while outdoor living horses showed very low levels. Amongst all positive reactions we observed only weak and moderate reactions but no strong positive reactions were found. No significant differences were observed between three breeds of horses with the exception of moulds and D. pteronyssinus allergens

scholarly journals The Relationship of Serum Antigen-Specific and Total Immunoglobulin E with Adult Cardiovascular Diseases

2018 ◽  
Vol 15 (11) ◽  
pp. 1098-1104 ◽  
Author(s):  
Zhiyan Xu ◽  
Tao Wang ◽  
Xiaoxiao Guo ◽  
Yao Li ◽  
Yi Hu ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Immunoglobulin E ◽  
Serum Antigen ◽  
Relationship Of ◽  
The Relationship ◽  
Total Immunoglobulin
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