Encapsulation and Pharmacokinetics of Drugs in Bovine and Canine Carrier Erythrocytes

2015 ◽  
pp. 36-41
Author(s):  
J. R. DeLoach
Keyword(s):  
Carrier Erythrocytes

Preparation and In Vitro Evaluation of Resealed Erythrocytes as A New Trend in Treatment of Asthma

2016 ◽  
Vol 6 (3) ◽  
Author(s):  
Mohammed Ibrahim ◽  
Alaa Zaky ◽  
Mohsen Afouna ◽  
Ahmed Samy
Keyword(s):  
In Vitro Release ◽  
Human Erythrocytes ◽  
The Body ◽  
Blood Levels ◽  
Time Interval ◽  
Burst Release ◽  
Prolonged Release ◽  
Nocturnal Asthma ◽  
Carrier Erythrocytes

Carrier erythrocytes are emerging as one of the most promising biological drug delivery systems investigated in recent decades. Beside its biocompatibility, biodegradability and ability to circulate throughout the body, it has the ability to perform extended release system of the drug for a long period. The ultimate goal of this study is to introduce a new carrier system for Salbutamol, maintaining suitable blood levels for a long time, as atrial to resolve the problems of nocturnal asthma medication Therefore in this work we study the effect of time, temperature as well as concentration on the loading of salbutamol in human erythrocytes to be used as systemic sustained release delivery system for this drug. After the loading process is performed the carrier erythrocytes were physically and cellulary characterized. Also, the in vitro release of salbutamol from carrier erythrocytes was studied over time interval. From the results it was found that, human erythrocytes have been successfully loaded with salbutamol using endocytosis method either at 25 Co or at 37 Co . The highest loaded amount was 3.5 mg/ml and 6.5 mg/ml respectively. Moreover, the percent of cells recovery is 90.7± 1.64%. Hematological parameters and osmotic fragility behavior of salbutamol loaded erythrocytes were similar that of native erythrocytes. Scanning electron microscopy demonstrated that the salbutamol loaded cells has moderate change in the morphology. Salbutamol releasing from carrier cell was 43% after 36 hours in phosphate buffer saline. The releasing pattern of the drug from loaded erythrocytes showed initial burst release in the first hour followed by a very slow release, obeying zero order kinetics. It concluded that salbutamol is successfully entrapped into erythrocytes with acceptable loading parameters and moderate morphological changes, this suggesting that erythrocytes can be used as prolonged release carrier for salbutamol.

In Vivo Survival of Human Energy-Replete Carrier Erythrocytes

1997 ◽  
pp. 25-30 ◽  
Author(s):  
Murray D. Bain ◽  
Bridget E. Bax ◽  
Peter J. Talbot ◽  
E. John Parker-Williams ◽  
Ronald A. Chalmers
Keyword(s):  
Carrier Erythrocytes ◽  
Human Energy

In vivo clearance of antibody-sensitized human drug carrier erythrocytes

1986 ◽  
Vol 40 (3) ◽  
pp. 300-303 ◽  
Author(s):  
H G Eichler ◽  
S Gasic ◽  
K Bauer ◽  
A Korn ◽  
S Bacher
Keyword(s):  
Drug Carrier ◽  
Carrier Erythrocytes

Factors associated with the performance of carrier erythrocytes obtained by hypotonic dialysis

2004 ◽  
Vol 33 (2) ◽  
pp. 132-140 ◽  
Author(s):  
Carmen Gutiérrez Millán ◽  
Aránzazu Zarzuelo Castañeda ◽  
Ma. Luisa Sayalero Marinero ◽  
José M. Lanao
Keyword(s):  
Factors Associated ◽  
Carrier Erythrocytes

Rhodanese and Sodium Thiosulfate Encapsulated in Mouse Carrier Erythrocytes

1991 ◽  
Vol 16 (3) ◽  
pp. 559-566 ◽  
Author(s):  
PETER LEUNG ◽  
RONALD W. DAVIS ◽  
C. C. YAO ◽  
E. P. CANNON ◽  
JAMES L. WAY
Keyword(s):  
Sodium Thiosulfate ◽  
Carrier Erythrocytes

Preparation and in vitro evaluation of carrier erythrocytes for RES-targeted delivery of interferon-alpha 2b

2007 ◽  
Vol 341 (1-2) ◽  
pp. 125-133 ◽  
Author(s):  
M. Hamidi ◽  
A.H. Zarrin ◽  
M. Foroozesh ◽  
N. Zarei ◽  
S. Mohammadi-Samani
Keyword(s):  
Interferon Alpha ◽  
Targeted Delivery ◽  
In Vitro Evaluation ◽  
Interferon Alpha 2B ◽  
Carrier Erythrocytes

scholarly journals Pharmacokinetics and biodistribution of amikacin encapsulated in carrier erythrocytes

2007 ◽  
Vol 61 (2) ◽  
pp. 375-381 ◽  
Author(s):  
C. G. Millan ◽  
A. Z. Castaneda ◽  
F. G. Lopez ◽  
M. L. S. Marinero ◽  
J. M. Lanao
Keyword(s):  
Carrier Erythrocytes

Increasing the selectivity of amikacin in rat peritoneal macrophages using carrier erythrocytes

2009 ◽  
Vol 38 (4) ◽  
pp. 320-324 ◽  
Author(s):  
Elsa Briones ◽  
Clara Isabel Colino ◽  
Carmen G. Millán ◽  
José M. Lanao
Keyword(s):  
Peritoneal Macrophages ◽  
Carrier Erythrocytes
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