Presence of Specific IgA Immune Complexes in IgA Nephropathy

2015 ◽  
pp. 80-86 ◽  
Author(s):  
J. Egido ◽  
J. Sancho ◽  
P. Hernando ◽  
J. Gonz�lez ◽  
L. Hernando
Keyword(s):  
Iga Nephropathy ◽  
Immune Complexes ◽  
Iga Immune Complexes

scholarly journals Microbial IgA Protease Removes IgA Immune Complexes from Mouse Glomeruli In Vivo: Potential Therapy for IgA Nephropathy

2008 ◽  
Vol 172 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Michael E. Lamm ◽  
Steven N. Emancipator ◽  
Janet K. Robinson ◽  
Michifumi Yamashita ◽  
Hisashi Fujioka ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Immune Complexes ◽  
Iga Immune Complexes ◽  
Iga Protease

Detection of bovine serum albumin in the circulating IgA immune complexes of patients with IgA nephropathy

1987 ◽  
Vol 43 (3) ◽  
pp. 395-402 ◽  
Author(s):  
Hui Kim Yap ◽  
Rebecca S. Sakai ◽  
Keng Thye Woo ◽  
Cheng Hong Lim ◽  
Stanley C. Jordan
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Iga Nephropathy ◽  
Immune Complexes ◽  
Bovine Serum ◽  
Iga Immune Complexes

Levels of Circulating IgA Immune Complexes after Gluten-Rich Diet in Patients with IgA Nephropathy

Nephron ◽  
1988 ◽  
Vol 49 (2) ◽  
pp. 104-106 ◽  
Author(s):  
Mitsunori Yagame ◽  
Yasuhiko Tomino ◽  
Kazuhiko Eguchi ◽  
Masahiko Miura ◽  
Takao Suga ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Immune Complexes ◽  
Iga Immune Complexes

scholarly journals IgA Glycosylation and IgA Immune Complexes in the Pathogenesis of IgA Nephropathy

2008 ◽  
Vol 28 (1) ◽  
pp. 78-87 ◽  
Author(s):  
Jan Novak ◽  
Bruce A. Julian ◽  
Milan Tomana ◽  
Jiri Mestecky
Keyword(s):  
Iga Nephropathy ◽  
Immune Complexes ◽  
Iga Immune Complexes

scholarly journals Experimental IgA nephropathy.

1979 ◽  
Vol 150 (5) ◽  
pp. 1161-1173 ◽  
Author(s):  
A Rifai ◽  
P A Small ◽  
P O Teague ◽  
E M Ayoub
Keyword(s):  
Iga Nephropathy ◽  
Immune Complex ◽  
Immune Complexes ◽  
Secretory Iga ◽  
Glomerular Lesions ◽  
Glomerular Deposits ◽  
Focal Glomerulonephritis ◽  
Iga Immune Complexes

An animal model for IgA immune complex nephritis was developed. IgA immune complexes formed in vitro with an IgA anti-dinitrophenyl (DNP) derived from MOPC-315 plasmacytoma, and dinitrophenylated bovine serum albumin (DNP-BSA) produced mild focal glomerulonephritis in mice. Similar, but more severe pathological changes were produced with complexes formed in vivo either in normal mice or MOPC-315 tumor-bearing mice. In contrast to the focal nature of the PAS-positive glomerular lesions observed by light microscopy, immunofluorescent examination revealed IgA deposits in all glomeruli. This discrepancy between immunofluorescent and histopathologic findings as well as the distribution of the immune complexes within the affected glomeruli, are some of the features which bear resemblance between this experimental model and human IgA nephropathy. Fixation of complements by DNP-BSA-IgA immune complexes, formed in vitro or in vivo, was shown to occur in the glomeruli of mice with IgA immune complex nephropathy. The pattern of C3 glomerular deposits was similar to that of IgA. However, complement proved to be nonessential for complex deposition. This conclusion is based on the observation that decomplemented mice, although showing no deposition of C3 in their glomerulus, developed glomerular immunohistological changes similar to those observed in experimental mice that were not decomplemented. Polymeric IgA was observed to be critical for renal deposition of complexes and induction of nephritic histological changes. In contrast, monomeric IgA immune complexes failed to produce glomerular deposits. This finding raises the possibility that secretory IgA, which is predominantly polymeric, may play a role in human IgA-associated glomerulonephritis.

scholarly journals Bacterial IgA protease-mediated degradation of agIgA1 and agIgA1 immune complexes as a potential therapy for IgA Nephropathy

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Li Wang ◽  
Xueying Li ◽  
Hongchun Shen ◽  
Nan Mao ◽  
Honglian Wang ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Immune Complexes ◽  
Iga Protease

Circulating IgA immune complexes in aids

1985 ◽  
Vol 14 (4) ◽  
pp. 341-345 ◽  
Author(s):  
Marilyn M. Lightfoote ◽  
Thomas M. Folks ◽  
Robert Redfield ◽  
Jonathan Gold ◽  
Kenneth W. Sell
Keyword(s):  
Immune Complexes ◽  
Iga Immune Complexes

Estimation of Circulating Immune Complexes following Oral Challenge with Cow’s Milk in Patients with IgA Nephropathy

Nephron ◽  
1987 ◽  
Vol 47 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Masashi Sato ◽  
Kimihiro Takayama ◽  
Mikio Wakasa ◽  
Shozo Koshikawa
Keyword(s):  
Iga Nephropathy ◽  
Immune Complexes ◽  
Circulating Immune Complexes ◽  
Oral Challenge ◽  
Cow’S Milk ◽  
Cow's Milk
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