T Antigen and Its Relation to Hemolytic Uremic Syndrome

2015 ◽  
pp. 35-45 ◽  
Author(s):  
R. P�sp�k ◽  
W. Graninger
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
T Antigen ◽  
Uremic Syndrome

scholarly journals Streptococcus Pneumoniae-Associated Hemolytic Uremic Syndrome in the Era of Pneumococcal Vaccine

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 727
Author(s):  
Hemant S Agarwal ◽  
Samir Q Latifi
Keyword(s):  
Streptococcus Pneumoniae ◽  
Hemolytic Uremic Syndrome ◽  
Randomized Clinical Trials ◽  
Pneumococcal Vaccination ◽  
T Antigen ◽  
Diagnostic Tools ◽  
Vaccine Failure ◽  
Uremic Syndrome ◽  
Antigen Antibody

Streptococcus pneumoniae-associated hemolytic uremic syndrome (Sp-HUS) is a serious complication of invasive pneumococcal disease that is associated with increased mortality in the acute phase and morbidity in the long term. Recently, Sp-HUS definition has undergone revision and cases are categorized as definite, probable, and possible, based on less invasive serological investigations that evaluate Thomsen-Friedenreich crypt antigen (T-antigen) activation. In comparison to the pre-vaccine era, Sp-HUS incidence seems to be decreasing after the introduction of 7-serotype valence and 13-serotype valence pneumococcal vaccines in 2000 and 2010, respectively. However, Sp-HUS cases continue to occur secondary to vaccine failure and emergence of non-vaccine/replacement serotypes. No single hypothesis elucidates the molecular basis for Sp-HUS occurrence, although pneumococcal neuraminidase production and formation of T-antigen antibody complexes on susceptible endothelial and red blood cells continues to remain the most acceptable explanation. Management of Sp-HUS patients remains supportive in nature and better outcomes are being reported secondary to earlier recognition, better diagnostic tools and improved medical care. Recently, the addition of eculizumab therapy in the management of Sp-HUS for control of dysregulated complement activity has demonstrated good outcomes, although randomized clinical trials are awaited. A sustained pneumococcal vaccination program and vigilance for replacement serotypes will be the key for persistent reduction in Sp-HUS cases worldwide.

Pneumococcus-induced T-antigen activation in hemolytic uremic syndrome and anemia

2004 ◽  
Vol 19 (3) ◽  
pp. 317-321 ◽  
Author(s):  
Joel B. Cochran ◽  
Valerie M. Panzarino ◽  
Lanne Y. Maes ◽  
Frederick W. Tecklenburg
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
T Antigen ◽  
Uremic Syndrome

T-antigen Activation for Prediction of Pneumococcus-Induced Hemolytic Uremic Syndrome and Hemolytic Anemia

2006 ◽  
Vol 25 (7) ◽  
pp. 608-610 ◽  
Author(s):  
Daniel Tsung-Ning Huang ◽  
Hsin Chi ◽  
Hung-Chang Lee ◽  
Nan-Chang Chiu ◽  
Fu-Yuan Huang
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Hemolytic Anemia ◽  
T Antigen ◽  
Uremic Syndrome

A case report of Streptococcus pneumoniae-induced hemolytic uremic syndrome: appropriate transfusional management by T-antigen determination

2013 ◽  
Vol 71 (2) ◽  
pp. 215-218
Author(s):  
Mélanie Rinaudo-Gaujous ◽  
Émilie Talagrand ◽  
Paul O. Verhoeven ◽  
Olivier Garraud ◽  
Françoise Flourié
Keyword(s):  
Case Report ◽  
Streptococcus Pneumoniae ◽  
Hemolytic Uremic Syndrome ◽  
T Antigen ◽  
Uremic Syndrome ◽  
Antigen Determination

Modern Trends in Demographics and Inpatient Healthcare Utilization for Hemolytic Uremic Syndrome in the U.S.A.

2014 ◽  
Vol 2 (2) ◽  
pp. 19
Author(s):  
H. Stella Shin ◽  
Brian Becknell ◽  
Patricia B. Reagan ◽  
John D. Mahan ◽  
David S. Hains
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Healthcare Utilization ◽  
Uremic Syndrome

Early Volume Expansion Improves the Outcome of Shigatoxin-Associated Hemolytic Uremic Syndrome. Data from the North Italian HUS Network

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 299A-299A
Author(s):  
Gianluigi Ardissino ◽  
Francesca Tel ◽  
Ilaria Possenti ◽  
Sara Testa ◽  
Dario Consonni ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Volume Expansion ◽  
The North ◽  
Uremic Syndrome

Early Volume Expansion Improves the Outcome of Shigatoxin-Associated Hemolytic Uremic Syndrome. Data from the North Italian HUS Network

2017 ◽  
Author(s):  
Gianluigi Ardissino ◽  
Francesca Tel ◽  
Ilaria Possenti ◽  
Sara Testa ◽  
Dario Consonni ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Volume Expansion ◽  
The North ◽  
Uremic Syndrome
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