A case report of Streptococcus pneumoniae-induced hemolytic uremic syndrome: appropriate transfusional management by T-antigen determination

2013 ◽  
Vol 71 (2) ◽  
pp. 215-218
Author(s):  
Mélanie Rinaudo-Gaujous ◽  
Émilie Talagrand ◽  
Paul O. Verhoeven ◽  
Olivier Garraud ◽  
Françoise Flourié
Keyword(s):  
Case Report ◽  
Streptococcus Pneumoniae ◽  
Hemolytic Uremic Syndrome ◽  
T Antigen ◽  
Uremic Syndrome ◽  
Antigen Determination

scholarly journals Streptococcus Pneumoniae-Associated Hemolytic Uremic Syndrome in the Era of Pneumococcal Vaccine

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 727
Author(s):  
Hemant S Agarwal ◽  
Samir Q Latifi
Keyword(s):  
Streptococcus Pneumoniae ◽  
Hemolytic Uremic Syndrome ◽  
Randomized Clinical Trials ◽  
Pneumococcal Vaccination ◽  
T Antigen ◽  
Diagnostic Tools ◽  
Vaccine Failure ◽  
Uremic Syndrome ◽  
Antigen Antibody

Streptococcus pneumoniae-associated hemolytic uremic syndrome (Sp-HUS) is a serious complication of invasive pneumococcal disease that is associated with increased mortality in the acute phase and morbidity in the long term. Recently, Sp-HUS definition has undergone revision and cases are categorized as definite, probable, and possible, based on less invasive serological investigations that evaluate Thomsen-Friedenreich crypt antigen (T-antigen) activation. In comparison to the pre-vaccine era, Sp-HUS incidence seems to be decreasing after the introduction of 7-serotype valence and 13-serotype valence pneumococcal vaccines in 2000 and 2010, respectively. However, Sp-HUS cases continue to occur secondary to vaccine failure and emergence of non-vaccine/replacement serotypes. No single hypothesis elucidates the molecular basis for Sp-HUS occurrence, although pneumococcal neuraminidase production and formation of T-antigen antibody complexes on susceptible endothelial and red blood cells continues to remain the most acceptable explanation. Management of Sp-HUS patients remains supportive in nature and better outcomes are being reported secondary to earlier recognition, better diagnostic tools and improved medical care. Recently, the addition of eculizumab therapy in the management of Sp-HUS for control of dysregulated complement activity has demonstrated good outcomes, although randomized clinical trials are awaited. A sustained pneumococcal vaccination program and vigilance for replacement serotypes will be the key for persistent reduction in Sp-HUS cases worldwide.

Therapeutic plasma exchange in Streptococcus pneumoniae-associated hemolytic uremic syndrome: A case report

2012 ◽  
Vol 27 (4) ◽  
pp. 212-214 ◽  
Author(s):  
Melissa L. Petras ◽  
Nancy M. Dunbar ◽  
James J. Filiano ◽  
Matthew S. Braga ◽  
Michael C. Chobanian ◽  
...  
Keyword(s):  
Case Report ◽  
Streptococcus Pneumoniae ◽  
Hemolytic Uremic Syndrome ◽  
Plasma Exchange ◽  
Therapeutic Plasma Exchange ◽  
Uremic Syndrome

scholarly journals Correction to: Hemolytic uremic syndrome caused by sea anemone sting: a case report

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
A. Young Kim ◽  
Kyu Hyang Cho ◽  
Seok Hui Kang ◽  
Jong Won Park ◽  
Jun Young Do ◽  
...  
Keyword(s):  
Case Report ◽  
Hemolytic Uremic Syndrome ◽  
Sea Anemone ◽  
Uremic Syndrome

Atypical Hemolytic Uremic Syndrome Associated with Complement Factor H Mutation and IgA Nephropathy: A Case Report Successfully Treated with Eculizumab

Nephron ◽  
2017 ◽  
Vol 138 (4) ◽  
pp. 324-327 ◽  
Author(s):  
Hironori Nakamura ◽  
Mariko Anayama ◽  
Mutsuki Makino ◽  
Yasushi Makino ◽  
Katsuhiko Tamura ◽  
...  
Keyword(s):  
Case Report ◽  
Hemolytic Uremic Syndrome ◽  
Iga Nephropathy ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Factor H ◽  
Complement Factor H ◽  
Complement Factor ◽  
Uremic Syndrome ◽  
Factor H Mutation

scholarly journals Gemcitabine and Hemolytic Uremic Syndrome: a Case Report

2017 ◽  
Vol 07 (02) ◽  
Author(s):  
Villalba NL ◽  
Merzouki T ◽  
Gonzalez NS ◽  
Ortiz MBA ◽  
Kechida M ◽  
...  
Keyword(s):  
Case Report ◽  
Hemolytic Uremic Syndrome ◽  
Uremic Syndrome
Sign in / Sign up

Export Citation Format

Share Document