Hypothalamic Control of ACTH Release from Dispersed Rat Pars Intermedia Cells

Hormones ◽  
2015 ◽  
pp. 171-181
Author(s):  
Jacob Kraicer
Keyword(s):  
Pars Intermedia ◽  
Hypothalamic Control ◽  
Acth Release

Hypothalamic Control of ACTH Release from Ectopic Pituitary Glands

Endocrinology ◽  
1969 ◽  
Vol 85 (4) ◽  
pp. 784-788 ◽  
Author(s):  
NANCY E. SIRETT ◽  
JOHN W. KENDALL
Keyword(s):  
Hypothalamic Control ◽  
Pituitary Glands ◽  
Acth Release

Ultrastructural investigation of an adenoma of the pituitary post mortem

1987 ◽  
Vol 45 ◽  
pp. 622-623
Author(s):  
Shirley Siew ◽  
W. C. deMendonca
Keyword(s):  
Deleterious Effect ◽  
Anterior Lobe ◽  
Definitive Diagnosis ◽  
Pars Intermedia ◽  
Post Mortem ◽  
Close Apposition ◽  
Autopsy Material ◽  
Progressive Loss ◽  
Transmission Electron ◽  
Means Of Transmission

The deleterious effect of post mortem degeneration results in a progressive loss of ultrastructural detail. This had led to reluctance (if not refusal) to examine autopsy material by means of transmission electron microscopy. Nevertheless, Johannesen has drawn attention to the fact that a sufficient amount of significant features may be preserved in order to enable the establishment of a definitive diagnosis, even on “graveyard” tissue.Routine histopathology of the autopsy organs of a woman of 78 showed the presence of a well circumscribed adenoma in the anterior lobe of the pituitary. The lesion came into close apposition to the pars intermedia. Its architecture was more compact and less vascular than that of the anterior lobe. However, there was some grouping of the cells in relation to blood vessels. The cells tended to be smaller, with a higher nucleocytoplasmic ratio. The cytoplasm showed a paucity of granules. In some of the cells, it was eosinophilic.

Influence of a Met-enkephalin analogue on CRF-induced ACTH release in normal individuals and patients with Cushing's disease

1985 ◽  
Vol 110 (1_Suppla) ◽  
pp. S17
Author(s):  
B. ALLOLIO ◽  
U. DEUSS ◽  
W. WINKELMANN ◽  
D. KAULEN ◽  
U. LEONHARDT ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Normal Individuals ◽  
Acth Release

THE RELATION BETWEEN THE HYPOTHALAMIC NEUROSECRETION AND THE CORTICOTROPHIN RELEASE IN EXPERIMENTAL CONDITIONS

1960 ◽  
Vol XXXIV (I) ◽  
pp. 8-18 ◽  
Author(s):  
E. Kivalo ◽  
U. K. Rinne
Keyword(s):  
Paraventricular Nucleus ◽  
Median Eminence ◽  
Supraoptic Nucleus ◽  
Acute Stress ◽  
Neurosecretory Material ◽  
Experimental Conditions ◽  
Hypothalamic Cells ◽  
The One ◽  
Hypophysial Portal ◽  
Acth Release

ABSTRACT Acute stress, chronic stress plus hydration, cortisone treatment, cortisone treatment plus dehydration were used as methods of investigation and the relation between the neurosecretory activity of the hypothalamic supraoptic nucleus and paraventricular nucleus and the neurosecretory material around the hypophysial portal vessels of the median eminence on the one hand and the corticotrophin release on the other hand, has been studied in the rat. Whereas stress stimulates both the activity of the above mentioned cells of the hypothalamus and the ACTH release, stress plus hydration causes a depression of these hypothalamic cells but nevertheless causes a marked ACTH release. Cortisone inhibits the activity of the cells in the supraoptic nucleus and the paraventricular nucleus as well as the ACTH release whereas cortisone plus dehydration causes stimulation but inhibits the ACTH release. In some stress and cortisone treatment groups the variations of the neurosecretory material around the hypophysial portal vessels and of the ACTH release were found to show a correlation. It is concluded that the activity of the cells of the supraoptic nucleus and the paraventricular nucleus and the ACTH release do not seem to have any definite connection, whereas some observations indicate that the neurosecretory material in the region of the median eminence around the hypophysial portal vessels may have some significance in ACTH release.

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