Epidemiology of Leukemia among Baboons of Sukhumi Monkey Colony

A prevalence survey for zoonotic enteric bacteria in a research monkey colony with specific emphasis on the occurrence of enteric Yersinia

Journal of Medical Primatology ◽

10.1111/j.1600-0684.2001.300103.x ◽

2001 ◽

Vol 30 (1) ◽

pp. 20-25 ◽

Cited By ~ 5

Author(s):

Stephen J. Vore ◽

Pamela D. Peele ◽

Peggy A. Barrow ◽

John F. Bradfield ◽

William H. Pryor Jr.

Keyword(s):

Enteric Bacteria ◽

Prevalence Survey ◽

Monkey Colony

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Modeling Man: The Monkey Colony at the Carnegie Institution of Washington’s Department of Embryology, 1925–1971

Journal of the History of Biology ◽

10.1007/s10739-011-9282-8 ◽

2011 ◽

Vol 45 (2) ◽

pp. 213-251 ◽

Cited By ~ 1

Author(s):

Emily K. Wilson

Keyword(s):

Carnegie Institution ◽

Monkey Colony

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A 75-year pictorial history of the Cayo Santiago rhesus monkey colony

American Journal of Primatology ◽

10.1002/ajp.22381 ◽

2015 ◽

Vol 78 (1) ◽

pp. 6-43 ◽

Cited By ~ 20

Author(s):

Matthew J. Kessler ◽

Richard G. Rawlins

Keyword(s):

Rhesus Monkey ◽

Cayo Santiago ◽

History Of ◽

Monkey Colony

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Cross-Species Transmission of a Novel Adenovirus Associated with a Fulminant Pneumonia Outbreak in a New World Monkey Colony

PLoS Pathogens ◽

10.1371/journal.ppat.1002155 ◽

2011 ◽

Vol 7 (7) ◽

pp. e1002155 ◽

Cited By ~ 84

Author(s):

Eunice C. Chen ◽

Shigeo Yagi ◽

Kristi R. Kelly ◽

Sally P. Mendoza ◽

Nicole Maninger ◽

...

Keyword(s):

New World ◽

World Monkey ◽

New World Monkey ◽

Monkey Colony

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Correction: Cross-Species Transmission of a Novel Adenovirus Associated with a Fulminant Pneumonia Outbreak in a New World Monkey Colony

PLoS Pathogens ◽

10.1371/annotation/c9a506d7-e8ba-4aaf-ab04-8ed0b383f5d9 ◽

2011 ◽

Vol 7 (8) ◽

Author(s):

Eunice C. Chen ◽

Shigeo Yagi ◽

Kristi R. Kelly ◽

Sally P. Mendoza ◽

Nicole Maninger ◽

...

Keyword(s):

New World ◽

World Monkey ◽

New World Monkey ◽

Monkey Colony

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Immunization against Natural Helicobacter pylori Infection in Nonhuman Primates

Infection and Immunity ◽

10.1128/iai.66.9.4340-4346.1998 ◽

1998 ◽

Vol 66 (9) ◽

pp. 4340-4346 ◽

Cited By ~ 54

Author(s):

Andre Dubois ◽

Cynthia K. Lee ◽

Nancy Fiala ◽

Harry Kleanthous ◽

Patrick T. Mehlman ◽

...

Keyword(s):

Escherichia Coli ◽

Helicobacter Pylori ◽

Side Effects ◽

Nonhuman Primates ◽

Safety And Efficacy ◽

Antral Gastritis ◽

Breeding Groups ◽

H Pylori ◽

To Receive ◽

Monkey Colony

ABSTRACT Helicobacter pylori infection is widespread in some breeding groups of a rhesus monkey colony (71% H. pyloripositive by 1 year), and the rate of seroconversion is also high. As a result, these groups can be used to test the safety and efficacy of an anti-H. pylori vaccine. Nine-month-old female animals were randomized to receive either 8 mg of recombinant urease (rUre) plus 25 μg of Escherichia coli heat-labile enterotoxin (LT) (n = 26) or placebo plus LT (n = 29), given four times at 1-week intervals followed by a booster 1 month later. Ten months after the start of the immunization, the animals were subjected to endoscopy and biopsy samples were obtained. H. pylori negativity was defined as no H. pylori growth by culture and no H. pylori observed at histology. By this criterion, 2 (7%) of 29 animals receiving placebo and 8 (31%) of 26 immunized animals were H. pylori negative (P < 0.035). In addition, antral gastritis score was significantly less in H. pylori-negative immunized monkeys than in H. pylori-positive animals, whether they were given rUre plus LT or placebo plus LT (P < 0.02 orP < 0.01, respectively). Interestingly, antral gastritis was also significantly less in H. pylori-positive animals given rUre plus LT than in H. pylori-positive animals given placebo plus LT (P < 0.02). However, quantitative cultures did not demonstrate significant differences between the two latter groups. It is concluded that oral administration of rUre vaccine plus LT significantly protects nonhuman primates against H. pylori infection while not causing undesirable side effects.

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