A Comparison of the Effects of Oestriol Succinate and Ethinyl Oestradiol on Blood Coagulation, Platelet Function and Fibrinolysis in Post-Menopausal Women

2015 ◽  
pp. 185-198 ◽  
Author(s):  
T. Davies ◽  
G. P. McNicol ◽  
G. Fieldhouse ◽  
J. C. Gallagher ◽  
B. E. C. Nordin
Keyword(s):  
Blood Coagulation ◽  
Platelet Function ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Ethinyl Oestradiol

The Effects of Therapy with Oestriol Succinate and Ethinyl Oestradiol on the Haemostatic Mechanism in Post-Menopausal Women

1976 ◽  
Vol 35 (02) ◽  
pp. 403-414 ◽  
Author(s):  
Terence Davies ◽  
Gillian Fieldhouse ◽  
George P. McNicol
Keyword(s):  
Coagulation Factors ◽  
Factor Vii ◽  
Oestrogen Therapy ◽  
Qualitative And Quantitative ◽  
Lysis Activity ◽  
Menopausal Women ◽  
Increased Sensitivity ◽  
Post Menopausal ◽  
Incremental Increase ◽  
Ethinyl Oestradiol

SummaryThe effects on the haemostatic mechanism of oestrogen therapy, given to prevent bone loss in post-menopausal women, have been investigated. Oestriol succinate was given orally to 10 women at a level of 2 mg/day for 1 month and for a further 3 months with incremental increase of 2 mg each month. 6 of the 10 women were subsequently treated with 25 μg/day orally of ethinyl oestradiol. Oestriol succinate therapy resulted in a small increase in the level of factor VII, a decrease in factor VIII concentration and increased sensitivity of platelets to aggregating agents. Ethinyl oestradiol treatment resulted in much more widespread changes with marked increases in coagulation factors VII, VIII, IX and X, decreased levels of antithrombin and dramatic increases in circulating plasminogen levels and euglobulin lysis activity. The data suggested that the nature of oestrogens employed therapeutically is important in determining the qualitative and quantitative effect of oestrogen therapy on components of the haemostatic mechanism.

Effects of Oral Ethinyl Oestradiol and Norethisterone on Plasma Copper and Zinc Complexes in Post-Menopausal Women

1985 ◽  
Vol 17 (10) ◽  
pp. 532-535 ◽  
Author(s):  
D. Chilvers ◽  
M. Jones ◽  
P. Selby ◽  
J. Dawson ◽  
A. Hodgkinson
Keyword(s):  
Zinc Complexes ◽  
Copper And Zinc ◽  
Menopausal Women ◽  
Plasma Copper ◽  
Post Menopausal ◽  
Ethinyl Oestradiol

scholarly journals Acute effects of calcium supplements on blood pressure and blood coagulation: secondary analysis of a randomised controlled trial in post-menopausal women

2015 ◽  
Vol 114 (11) ◽  
pp. 1868-1874 ◽  
Author(s):  
Sarah M. Bristow ◽  
Greg D. Gamble ◽  
Angela Stewart ◽  
Anne M. Horne ◽  
Ian R. Reid
Keyword(s):  
Blood Pressure ◽  
Blood Coagulation ◽  
Controlled Trial ◽  
Secondary Analysis ◽  
Control Group ◽  
Calcium Citrate ◽  
Acute Effects ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Randomised Controlled

AbstractRecent evidence suggests that Ca supplements increase the risk of cardiovascular events, but the mechanism(s) by which this occurs is uncertain. In a study primarily assessing the effects of various Ca supplements on blood Ca levels, we also investigated the effects of Ca supplements on blood pressure and their acute effects on blood coagulation. We randomised 100 post-menopausal women to 1 g/d of Ca or a placebo containing no Ca. Blood pressure was measured at baseline and every 2 h up to 8 h after their first dose and after 3 months of supplementation. Blood coagulation was measured by thromboelastography (TEG) in a subgroup of participants (n 40) up to 8 h only. Blood pressure declined over 8 h in both the groups, consistent with its normal diurnal rhythm. The reduction in systolic blood pressure was smaller in the Ca group compared with the control group by >5 mmHg between 2 and 6 h (P≤0·02), and the reduction in diastolic blood pressure was smaller at 2 h (between-groups difference 4·5 mmHg, P=0·004). Blood coagulability, assessed by TEG, increased from baseline over 8 h in the calcium citrate and control groups. At 4 h, the increase in the coagulation index was greater in the calcium citrate group compared with the control group (P=0·03), which appeared to be due to a greater reduction in the time to clot initiation. These data suggest that Ca supplements may acutely influence blood pressure and blood coagulation. Further investigation of this possibility is required.

scholarly journals The Copenhagen Women Study: preliminary data related to cardiovascular health

2015 ◽  
Author(s):  
Ylva Hellsten ◽  
Martina Slingsby ◽  
Jon Egelund ◽  
Jens Bangsbo ◽  
Michael Nyberg
Keyword(s):  
Physical Activity ◽  
Health Status ◽  
Platelet Function ◽  
Preliminary Data ◽  
Daily Activity ◽  
Cardiovascular Health ◽  
Estrogen Replacement ◽  
Menopausal Women ◽  
Health Related ◽  
Post Menopausal

Background : After menopause women experience a markedly increased risk of cardiovascular events due to the loss of estrogen. As estrogen replacement is associated with negative side effects, a more attractive alternative to help maintain a good cardiovascular and metabolic health status may be regular physical activity. In this ongoing study, our aim is to elucidate the beneficial effects of a period of physical activity on a number of health related parametres in pre- and post-menopausal women. Methods : The study has been approved by the ethics committee of Capitol Region of Denmark (H-1-2012-150). Informed consent was given by the participants prior to inclusion in the study. Pre and post menopausal women, between the age of 45 and 57 years of age are recruited. The women are sedentary non-smokers with no known chronic diseases. The women undergo a three month training program with spinning training three times per week. Before and after the training period they are characterized with regard to daily activity level by use of accelerometry ( actibelt ® ), food intake, body composition, fitness level, cardiac function, platelet function, and vascular function. Results : As the study is ongoing, results are preliminary. Based on our practical experience so far we can conclude that actibelt ® is an effective and well-functioning means of determining daily activity. Moreover, the preliminary data indicate that post-menopausal women have reduced vascular and platelet function compared to pre-menopausal women. The study also shows that aspects of both vascular and platelet function appear to be improved by the three month training period. Both pre and post-menopausal women experience improved fitness levels and plasma lipid profile. Discussion/conclusion : The preliminary data from this study show that already soon after menopause impairments occur in cardiovascular health status and that these impairments may be more related to the loss of estrogen than to age. Exercise training by spinning is an effective mean to improve fitness and a number of health related parametres in middle aged women. We propose that physical activity can be a valuable alternative to estrogen replacement.

scholarly journals The Copenhagen Women Study: preliminary data related to cardiovascular health

2015 ◽  
Author(s):  
Ylva Hellsten ◽  
Martina Slingsby ◽  
Jon Egelund ◽  
Jens Bangsbo ◽  
Michael Nyberg
Keyword(s):  
Physical Activity ◽  
Health Status ◽  
Platelet Function ◽  
Preliminary Data ◽  
Daily Activity ◽  
Cardiovascular Health ◽  
Estrogen Replacement ◽  
Menopausal Women ◽  
Health Related ◽  
Post Menopausal

Background : After menopause women experience a markedly increased risk of cardiovascular events due to the loss of estrogen. As estrogen replacement is associated with negative side effects, a more attractive alternative to help maintain a good cardiovascular and metabolic health status may be regular physical activity. In this ongoing study, our aim is to elucidate the beneficial effects of a period of physical activity on a number of health related parametres in pre- and post-menopausal women. Methods : The study has been approved by the ethics committee of Capitol Region of Denmark (H-1-2012-150). Informed consent was given by the participants prior to inclusion in the study. Pre and post menopausal women, between the age of 45 and 57 years of age are recruited. The women are sedentary non-smokers with no known chronic diseases. The women undergo a three month training program with spinning training three times per week. Before and after the training period they are characterized with regard to daily activity level by use of accelerometry ( actibelt ® ), food intake, body composition, fitness level, cardiac function, platelet function, and vascular function. Results : As the study is ongoing, results are preliminary. Based on our practical experience so far we can conclude that actibelt ® is an effective and well-functioning means of determining daily activity. Moreover, the preliminary data indicate that post-menopausal women have reduced vascular and platelet function compared to pre-menopausal women. The study also shows that aspects of both vascular and platelet function appear to be improved by the three month training period. Both pre and post-menopausal women experience improved fitness levels and plasma lipid profile. Discussion/conclusion : The preliminary data from this study show that already soon after menopause impairments occur in cardiovascular health status and that these impairments may be more related to the loss of estrogen than to age. Exercise training by spinning is an effective mean to improve fitness and a number of health related parametres in middle aged women. We propose that physical activity can be a valuable alternative to estrogen replacement.

Natural Oestrogen in the Female Climacteric - Influence on Blood Coagulation and Fibrinolysis

1978 ◽  
Vol 40 (02) ◽  
pp. 532-541 ◽  
Author(s):  
Anders Lagrelius ◽  
Nils-Olov Lunell ◽  
Margareta Blombäck
Keyword(s):  
Blood Coagulation ◽  
Antithrombin Iii ◽  
Coagulation Factors ◽  
Control Group ◽  
Blood Coagulation Factors ◽  
Excessive Bleeding ◽  
Oestrone Sulphate ◽  
Menopausal Women ◽  
History Of ◽  
Coagulation And Fibrinolysis

SummaryThe aim of the present study was to investigate the effect on blood coagulation and fibrinolysis of a natural oestrogen preparation, piperazine oestrone sulphate, prospectively in menopausal women. Scopolamine was given to the control group.The women were investigated before and during treatment with regard to factors VIII, VII, X, V, fibrinopeptide A, antithrombin III, plasminogen, rapid antiplasmin and α1-antitrypsin. There was no significant change towards hypercoagulability or decreased fibrinolysis in any group. In the oestrogen group, however, a tendency towards an increased level of plasminogen and a decreased level of antiplasmin was demonstrated. In the scopolamine group there was an unexpected fall in factors X and V and also in plasminogen and α1,-antitrypsin. A low level of some blood coagulation factors in some of the women before treatment is somewhat astonishing; none of them had any history of excessive bleeding.

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