The Role of Polycythaemia in the Development of Experimental High Altitude Hypertension and Right Ventricular Hypertrophy

2015 ◽  
pp. 130-137 ◽  
Author(s):  
B. Oštádal ◽  
J. Ressl ◽  
D. Urbanová ◽  
J. Widimsk� ◽  
J. Procházka ◽  
...  
Keyword(s):  
Right Ventricular ◽  
High Altitude ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy

Role of microRNA-21 in right ventricular hypertrophy and fibrosis

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
J Neumann ◽  
W Janssen ◽  
B Kojonazarov ◽  
C Döbele ◽  
HA Ghofrani ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy

Further evidence for the involvement of anatomical parameters of the cardiopulmonary system in the development of ascites syndrome in broiler chickens

2008 ◽  
Vol 56 (1) ◽  
pp. 71-80 ◽  
Author(s):  
Mohammad Hassanzadeh ◽  
Johan Buyse ◽  
Eddy Decuypere
Keyword(s):  
Right Ventricular ◽  
High Altitude ◽  
Broiler Chickens ◽  
Ventricular Hypertrophy ◽  
Developmental Trajectories ◽  
Right Ventricular Hypertrophy ◽  
Thoracic Cavity ◽  
Low Altitude ◽  
Cardiopulmonary System ◽  
Anatomical Parameters

Eggs from a broiler line were incubated at two different altitudes and hatched. Relative heart and lung weights, volumes of the heart, lung and thoracic cavity, incidence of right ventricular hypertrophy and ascites, and related physiological parameters were followed in the day-old chickens hatched from the above eggs. Lung and heart weights as a percentage of body weight, lung and heart volumes relative to the volume of the thoracic cavity after removing the heart and lungs were higher in chickens hatched at high altitude. Additionally, embryonic triiodothyronine (T3) and thyroxine (T4) levels relative to cardiopulmonary parameters were higher in day-old chickens that hatched at high altitude as compared with chickens hatched at low altitude. This was associated with a lower incidence of right ventricular hypertrophy and ascites in chickens hatched at high altitude. Our data indicate that chronic hypoxia interacting with the endogenous functions of embryos during embryonic development at high altitude, as adaptation mechanisms, changed the developmental trajectories of cardiopulmonary parameters in postnatal chickens. This important development facilitates an increase in the gas exchange area in broiler chickens, thus lowering their susceptibility to pulmonary hypertension and ascites.

Crucial Role of Rho-kinase in Pressure-overload-induced Right Ventricular Hypertrophy and Dysfunction in Mice

2014 ◽  
Vol 20 (10) ◽  
pp. S144
Author(s):  
Shohei Ikeda ◽  
Kimio Satoh ◽  
Nobuhiro Kikuchi ◽  
Satoshi Miyata ◽  
Kota Suzuki ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Crucial Role ◽  
Ventricular Hypertrophy ◽  
Rho Kinase ◽  
Pressure Overload ◽  
Right Ventricular Hypertrophy

Role of hypoxia-induced anorexia and right ventricular hypertrophy on lactate transport and MCT expression in rat muscle

Metabolism ◽  
2005 ◽  
Vol 54 (5) ◽  
pp. 634-644 ◽  
Author(s):  
Guillaume Py ◽  
Nicolas Eydoux ◽  
Karen Lambert ◽  
Rachel Chapot ◽  
Natahlie Koulmann ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy ◽  
Lactate Transport ◽  
Rat Muscle

scholarly journals Crucial Role of Rho-Kinase in Pressure Overload–Induced Right Ventricular Hypertrophy and Dysfunction in Mice

2014 ◽  
Vol 34 (6) ◽  
pp. 1260-1271 ◽  
Author(s):  
Shohei Ikeda ◽  
Kimio Satoh ◽  
Nobuhiro Kikuchi ◽  
Satoshi Miyata ◽  
Kota Suzuki ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Crucial Role ◽  
Ventricular Hypertrophy ◽  
Rho Kinase ◽  
Pressure Overload ◽  
Right Ventricular Hypertrophy

scholarly journals Contractile reserve but not tension is reduced in monocrotaline-induced right ventricular hypertrophy

2004 ◽  
Vol 286 (3) ◽  
pp. H979-H984 ◽  
Author(s):  
J. Pieter Versluis ◽  
Johannes W. Heslinga ◽  
Pieter Sipkema ◽  
Nico Westerhof
Keyword(s):  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Vehicle Control ◽  
Right Ventricular Hypertrophy ◽  
Calcium Handling ◽  
Contractile Reserve ◽  
Maximal Tension ◽  
Recirculation Fraction ◽  
Rat Papillary Muscle

The objective of this study was to evaluate the role of right ventricular hypertrophy on developed tension (Fdev) and contractile reserve of rat papillary muscle by using a model of monocrotaline (Mct)-induced pulmonary hypertension. Calcium handling and the influence of bicarbonate ([Formula: see text]) were also addressed with the use of two different buffers ([Formula: see text] and HEPES). Wistar rats were injected with either Mct (40 mg/kg sc) or vehicle control (Con). Isometrically contracting right ventricular papillary muscles were studied at 80% of the length of maximal developed force. Contractile reserve (1 – Fdev/Fmax) was calculated from Fdev and maximal tension (Fmax). Calcium recirculation was determined with postextrasystolic potentiation. Both groups of muscles were superfused with either [Formula: see text] (Con-B and Mct-B, both n = 6) or HEPES (Con-H and Mct-H, both n = 6) buffer. With hypertrophy, contractions were slower but Fdev was not changed. However, Fmax was decreased ( P < 0.05). With [Formula: see text], Fmax decreased from 23.8 ± 6.5 mN·mm–2 in Con-B, to 13.7 ± 3.3 mN·mm–2 in Mct-B. With HEPES, it decreased from 16.3 ± 3.5 mN·mm–2 ( n = 6, Con-H) to 8.3 ± 1.6 mN·mm–2 (Mct-H). Contractile reserve during hypertrophy was therefore also decreased ( P < 0.05). With [Formula: see text], it decreased from 0.73 ± 0.03 (Con-B) to 0.55 ± 0.04 (Mct-B). With HEPES, it decreased ( P < 0.001) from 0.64 ± 0.07 (Con-H) to 0.19 ± 0.06 (Mct-H). The recirculation fraction decreased ( P < 0.05) from 0.59 ± 0.04 in Con-B to 0.44 ± 0.04 in Mct-B. We conclude that contractile reserve and recirculation fraction are impaired during hypertrophy, with a stronger effect under HEPES than [Formula: see text] superfusion.

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