Calcium Handling and Role of Endothelin-1 in Monocrotaline Right Ventricular Hypertrophy of the Rat

2000 ◽  
Vol 32 (11) ◽  
pp. 1995-2005 ◽  
Author(s):  
Gerald Wölkart ◽  
Hinrik Strömer ◽  
Friedrich Brunner
Keyword(s):  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy ◽  
Calcium Handling ◽  
Endothelin 1

scholarly journals Contractile reserve but not tension is reduced in monocrotaline-induced right ventricular hypertrophy

2004 ◽  
Vol 286 (3) ◽  
pp. H979-H984 ◽  
Author(s):  
J. Pieter Versluis ◽  
Johannes W. Heslinga ◽  
Pieter Sipkema ◽  
Nico Westerhof
Keyword(s):  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Vehicle Control ◽  
Right Ventricular Hypertrophy ◽  
Calcium Handling ◽  
Contractile Reserve ◽  
Maximal Tension ◽  
Recirculation Fraction ◽  
Rat Papillary Muscle

The objective of this study was to evaluate the role of right ventricular hypertrophy on developed tension (Fdev) and contractile reserve of rat papillary muscle by using a model of monocrotaline (Mct)-induced pulmonary hypertension. Calcium handling and the influence of bicarbonate ([Formula: see text]) were also addressed with the use of two different buffers ([Formula: see text] and HEPES). Wistar rats were injected with either Mct (40 mg/kg sc) or vehicle control (Con). Isometrically contracting right ventricular papillary muscles were studied at 80% of the length of maximal developed force. Contractile reserve (1 – Fdev/Fmax) was calculated from Fdev and maximal tension (Fmax). Calcium recirculation was determined with postextrasystolic potentiation. Both groups of muscles were superfused with either [Formula: see text] (Con-B and Mct-B, both n = 6) or HEPES (Con-H and Mct-H, both n = 6) buffer. With hypertrophy, contractions were slower but Fdev was not changed. However, Fmax was decreased ( P < 0.05). With [Formula: see text], Fmax decreased from 23.8 ± 6.5 mN·mm–2 in Con-B, to 13.7 ± 3.3 mN·mm–2 in Mct-B. With HEPES, it decreased from 16.3 ± 3.5 mN·mm–2 ( n = 6, Con-H) to 8.3 ± 1.6 mN·mm–2 (Mct-H). Contractile reserve during hypertrophy was therefore also decreased ( P < 0.05). With [Formula: see text], it decreased from 0.73 ± 0.03 (Con-B) to 0.55 ± 0.04 (Mct-B). With HEPES, it decreased ( P < 0.001) from 0.64 ± 0.07 (Con-H) to 0.19 ± 0.06 (Mct-H). The recirculation fraction decreased ( P < 0.05) from 0.59 ± 0.04 in Con-B to 0.44 ± 0.04 in Mct-B. We conclude that contractile reserve and recirculation fraction are impaired during hypertrophy, with a stronger effect under HEPES than [Formula: see text] superfusion.

Role of microRNA-21 in right ventricular hypertrophy and fibrosis

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
J Neumann ◽  
W Janssen ◽  
B Kojonazarov ◽  
C Döbele ◽  
HA Ghofrani ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy

Crucial Role of Rho-kinase in Pressure-overload-induced Right Ventricular Hypertrophy and Dysfunction in Mice

2014 ◽  
Vol 20 (10) ◽  
pp. S144
Author(s):  
Shohei Ikeda ◽  
Kimio Satoh ◽  
Nobuhiro Kikuchi ◽  
Satoshi Miyata ◽  
Kota Suzuki ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Crucial Role ◽  
Ventricular Hypertrophy ◽  
Rho Kinase ◽  
Pressure Overload ◽  
Right Ventricular Hypertrophy

Role of hypoxia-induced anorexia and right ventricular hypertrophy on lactate transport and MCT expression in rat muscle

Metabolism ◽  
2005 ◽  
Vol 54 (5) ◽  
pp. 634-644 ◽  
Author(s):  
Guillaume Py ◽  
Nicolas Eydoux ◽  
Karen Lambert ◽  
Rachel Chapot ◽  
Natahlie Koulmann ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy ◽  
Lactate Transport ◽  
Rat Muscle

scholarly journals Crucial Role of Rho-Kinase in Pressure Overload–Induced Right Ventricular Hypertrophy and Dysfunction in Mice

2014 ◽  
Vol 34 (6) ◽  
pp. 1260-1271 ◽  
Author(s):  
Shohei Ikeda ◽  
Kimio Satoh ◽  
Nobuhiro Kikuchi ◽  
Satoshi Miyata ◽  
Kota Suzuki ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Crucial Role ◽  
Ventricular Hypertrophy ◽  
Rho Kinase ◽  
Pressure Overload ◽  
Right Ventricular Hypertrophy
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