Nature and Importance of Endogenous Fatty Acids during Intestinal Absorption of Fats

2015 ◽  
pp. 281-307 ◽  
Author(s):  
J. Clement
Keyword(s):  
Fatty Acids ◽  
Intestinal Absorption

scholarly journals Electron microscope autoradiographic study of intestinal absorption of decanoic and octanoic acids in the rat.

1975 ◽  
Vol 65 (2) ◽  
pp. 383-397 ◽  
Author(s):  
H Carlier ◽  
J Bezard
Keyword(s):  
Fatty Acids ◽  
Electron Microscope ◽  
Intestinal Absorption ◽  
Common Duct ◽  
Autoradiographic Study ◽  
Electron Microscope Autoradiography ◽  
Blood Capillaries ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Chain Fatty Acids

Intestinal absorption of [3H]octanoic acid and [3H]decanoic acid was investigated in the rat by electron microscope autoradiography. The common duct (bile and pancreatic common duct) of the rats was diverted and a loop of the duodenum was cannulated 24 h later. The lipid mixture to be investigated was introduced into each experimental loop, and after 15 min or less the loop was removed. One part of each loop was used to determine the distribution of radioactivity in different lipid fractions, and an autoradiographic study was performed on the other part of the loop. Radioactivity distribution studies confirmed that medium chain fatty acids are absorbed in their nonesterified form and established that these fatty acids are absorbed much more rapidly than oleic acid. Autoradiographic studies indicated that the medium chain fatty acids are taken up in a molecular or aggregate molecular form, leave the epithelial cells by way of the lateral plasma membrane, and are next found in the blood capillaries. Our results suggest that the Golgi complex does not play an important role in the absorption of unesterified fatty acids.

Lipid Absorption and Deposition in Rainbow Trout (Salmo gairdnerii)

1973 ◽  
Vol 51 (7) ◽  
pp. 1050-1058 ◽  
Author(s):  
J. Stephen Robinson ◽  
James F. Mead
Keyword(s):  
Fatty Acids ◽  
Rainbow Trout ◽  
Palmitic Acid ◽  
Free Fatty Acids ◽  
Intestinal Absorption ◽  
Lipid Absorption ◽  
Portal System ◽  
Absorption Mechanism ◽  
Dark Muscle ◽  
Muscle Lipids

Rainbow trout, fed or starved for 5 weeks, were force-fed 23 μCi 1-14C-palmitic acid and sacrificed at [Formula: see text], 1, 2, 4, 8, and 14 h after feeding. Analysis of the blood suggested that trout possess an intestinal absorption mechanism for lipid that is very different from that found in other animals. The fish, incapable of delivering triglyceride to its circulation in the usual way, receives most of its absorbed lipid as free fatty acids, probably via the portal system. It was also found that light muscle more easily yielded its triglyceride stores, in agreement with its role as the major lipid depot in trout. Nonetheless, dark muscle was metabolically more active in deposition of muscle lipids. Dark muscle appeared to function more as an organ than a kinetically responsible contractile body.

scholarly journals Intestinal absorption and liver uptake of medium-chain fatty acids in non-anaesthetized pigs

1993 ◽  
Vol 69 (2) ◽  
pp. 431-442 ◽  
Author(s):  
E. Guillot ◽  
P. Vaugelade ◽  
P. Lemarchali ◽  
A. Re Rat
Keyword(s):  
Fatty Acids ◽  
Portal Vein ◽  
Intestinal Absorption ◽  
Time Course ◽  
Decanoic Acid ◽  
Growing Pigs ◽  
Portal Blood ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Chain Fatty Acids

In order to study the rate of intestinal absorption and hepatic uptake of medium-chain fatty acids (MCFA), six growing pigs, mean body weight 65 kg, were fitted with a permanent fistula in the duodenum and with three catheters in the portal vein, carotid artery and hepatic vein respectively. Two electromagnetic flow probes were also set up, one around the portal vein and one around the hepatic artery. A mixture of octanoic and decanoic acids, esterified as medium-chain triacylglycerols, together with maltose dextrine and a nitrogenous fraction was continuously infused for 1 h into the duodenum. Samples of blood were withdrawn from the three vessels at regular intervals for 12 h and further analysed for their non-esterified octanoic and decanoic acid contents. The concentration of non-esterified octanoic and decanoic acids in the portal blood rose sharply after the beginning of each infusion and showed a biphasic time-course with two maximum values, one after 15 min and a later one between 75 and 90 min. Only 65 % of octanoic acid infused into the duodenum and 54 % of decanoic acid were recovered in the portal flow throughout each experiment. The amounts of non-esterified MCFA taken up per h by the liver were close to those absorbed from the gut via the portal vein within the same periods of time, showing that the liver is the main site of utilization of MCFA in pigs. These results have been discussed with a special emphasis laid on the possible mechanisms of the biphasic time-course of MCFA absorption and the incomplete recovery in the portal blood of the infused fatty acids.

scholarly journals Effect of pre-administered fats and fatty acids on the intestinal absorption of tryptophan in the rat.

1976 ◽  
Vol 24 (12) ◽  
pp. 3075-3080
Author(s):  
KENICHI INUI ◽  
HIROKAZU YAMAKITA ◽  
RYOHEI HORI
Keyword(s):  
Fatty Acids ◽  
Intestinal Absorption
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