Restored Immune and Nonimmune Functions in Friend Virus Leukemic Mice Treated with Statolon1

2015 ◽  
pp. 369-389 ◽  
Author(s):  
E. Frederick Wheelock ◽  
Stephen T. Toy ◽  
Owen S. Weislow ◽  
Michael H. Levy
Keyword(s):  
Friend Virus

Suggestive Evidence for an Oncorna-Virus-Specific DNA Polymerase from C-Type Particles of Bovine Leukosis

1974 ◽  
Vol 29 (1-2) ◽  
pp. 72-75 ◽  
Author(s):  
B. Dietzschold ◽  
O.R. Kaaden ◽  
S. Ueberschaer ◽  
F. Weiland ◽  
O. C. Straub
Keyword(s):  
Dna Polymerase ◽  
Polymerase Activity ◽  
Friend Virus ◽  
Leukaemia Virus ◽  
Virus Particles ◽  
Virus Rna ◽  
Feline Leukaemia Virus ◽  
Bovine Leukosis ◽  
Bovine Lymphocytes ◽  
Viral Preparation

Abstract Typical C-type oncorna virus particles as shown by electron microscopy have been purified from the supernatant of cultured lymphocytes from bovine leukosis. In the purified C-particle fraction a DNA-polymerase activity was detected. Using several synthetic RNA-or DNA-homopolymers and 70S Friend virus RNA the template response of this bovine leukosis cell particle DNA polymerase was compared with those of feline leukaemia virus DNA polymerase and DNA polymerase from normal bovine lymphocytes. The DNA polymerase detected in the viral preparation of bovine leukosis is suggested to be an oncorna-virus-specific enzyme.

scholarly journals Isolation of erythropoietin-sensitive cells from Friend virus-infected marrow cultures: characteristics of the erythropoietin response

Blood ◽  
1983 ◽  
Vol 61 (4) ◽  
pp. 751-758 ◽  
Author(s):  
M Bondurant ◽  
M Koury ◽  
SB Krantz ◽  
T Blevins ◽  
DT Duncan
Keyword(s):  
Terminal Differentiation ◽  
Erythroid Differentiation ◽  
Precursor Cells ◽  
Erythroid Cells ◽  
Friend Virus ◽  
Isolated Cells ◽  
Two Dimensional Gel Electrophoresis ◽  
Erythroid Precursor ◽  
Short Time

Abstract Murine erythroid precursor cells, stimulated to proliferate in vitro in the absence of added erythropoietin (EP) by the anemia strain of Friend virus (FVA), will subsequently respond to EP by complete erythrocyte differentiation. If not exposed to EP, the erythroid cells divide for about 120 hr in culture, and they maintain the potential for full differentiation in response to EP added at any time during the period from 72 to 120 hr. Between 96 and 120 hr of culture without added EP, the EP-sensitive erythroid precursor cells that have formed discrete erythroid bursts can be isolated in relatively large numbers from such cultures by plucking with a Pasteur pipette. The addition of EP initiates the final stages of erythroid differentiation, including heme synthesis in 70%-80% of these isolated cells. With respect to homogeneity of the precursor cells, quantity of EP-responsive cells obtainable, and uniformity of EP responsiveness, this system is uniquely favorable for biochemical studies of the late differentiation effects of EP. The overall changes in gene expression accompanying EP- induced terminal differentiation were examined by two-dimensional gel electrophoresis of proteins labeled for a short time with radioactive amino acids. Several new proteins are synthesized in these erythroid cells during terminal differentiation, but the number is a very small percentage of the total number of proteins being made. Thus, in this system, the effect of EP is to initiate expression of a small group of genes, including those for globins, spectrin, and other proteins involved in the final stages of erythroid differentiation.

Spontaneous regression of friend virus-induced erythroleukemia—VIII. Humoral immune reactivity in regressed and leukemic mice

1981 ◽  
Vol 5 (1) ◽  
pp. 41-55 ◽  
Author(s):  
David L. Hines ◽  
Michael Dietz ◽  
John Marcelletti ◽  
Philip Furmanski
Keyword(s):  
Spontaneous Regression ◽  
Immune Reactivity ◽  
Friend Virus ◽  
Humoral Immune

Transcription of Friend Virus Proviral Sequences in Isolated Nuclei

1980 ◽  
Vol 104 (2) ◽  
pp. 459-467 ◽  
Author(s):  
T. David K. BROWN ◽  
Ian B. PRAGNELL ◽  
John PAUL
Keyword(s):  
Friend Virus ◽  
Isolated Nuclei

scholarly journals Premature Terminal Exhaustion of Friend Virus-Specific Effector CD8+T Cells by Rapid Induction of Multiple Inhibitory Receptors

2010 ◽  
Vol 184 (9) ◽  
pp. 4696-4707 ◽  
Author(s):  
Shiki Takamura ◽  
Sachiyo Tsuji-Kawahara ◽  
Hideo Yagita ◽  
Hisaya Akiba ◽  
Mayumi Sakamoto ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Inhibitory Receptors ◽  
Friend Virus ◽  
Rapid Induction ◽  
Specific Effector
Sign in / Sign up

Export Citation Format

Share Document