Studies on the resistance of the C 57 Bl/6 mouse strain to the polycythemia-inducing strain of the Friend virus (FV-P)

1981 ◽  
Vol 42 (3) ◽  
pp. 173-182 ◽  
Author(s):  
H. J. Seidel ◽  
L. Kreja
Keyword(s):  
Mouse Strain ◽  
Friend Virus

scholarly journals THE EFFECT OF HISTOCOMPATIBILITY-2 TYPE ON RESPONSE TO THE FRIEND LEUKEMIA VIRUS IN MICE

1968 ◽  
Vol 127 (3) ◽  
pp. 465-473 ◽  
Author(s):  
Frank Lilly
Keyword(s):  
Mouse Strain ◽  
Leukemia Virus ◽  
Single Pair ◽  
Friend Virus ◽  
Relative Susceptibility ◽  
Friend Leukemia ◽  
Low Levels ◽  
High Virus ◽  
Friend Leukemia Virus ◽  
Quantitative Response

Two types of quantitative response to the F-B strain of Friend virus in segregating generations of a cross involving a susceptible (DBA/2 or BALB/c; H-22) and a resistant (C57BL/6; H-2b) mouse strain show a marked correlation with the H-2 type of the mice. Essential susceptibility, as determined by the splenomegalic response to high virus doses, is controlled by a single pair of alleles which segregates independently with respect to the H-2 locus. However, relative susceptibility, as determined by the incidence of the splenomegalic response at moderate or low levels of virus dosage, is significantly greater among mice homozygous or heterozygous for the H-2d allele than among H-2b homozygotes in these populations. In addition, the incidence of recovery from splenomegaly induced by a given level of virus dosage is significantly greater in H-2b homozygotes than in segregants of other H-2 types among their littermates. Possible mechanisms responsible for these effects are discussed.

Mouse strain resistant to N-, B-, and NB-tropic murine leukemia viruses.

1976 ◽  
Vol 20 (2) ◽  
pp. 436-440 ◽  
Author(s):  
K Kai ◽  
H Ikeda ◽  
Y Yuasa ◽  
S Suzuki ◽  
T Odaka
Keyword(s):  
Mouse Strain ◽  
Leukemia Viruses ◽  
Murine Leukemia

Suggestive Evidence for an Oncorna-Virus-Specific DNA Polymerase from C-Type Particles of Bovine Leukosis

1974 ◽  
Vol 29 (1-2) ◽  
pp. 72-75 ◽  
Author(s):  
B. Dietzschold ◽  
O.R. Kaaden ◽  
S. Ueberschaer ◽  
F. Weiland ◽  
O. C. Straub
Keyword(s):  
Dna Polymerase ◽  
Polymerase Activity ◽  
Friend Virus ◽  
Leukaemia Virus ◽  
Virus Particles ◽  
Virus Rna ◽  
Feline Leukaemia Virus ◽  
Bovine Leukosis ◽  
Bovine Lymphocytes ◽  
Viral Preparation

Abstract Typical C-type oncorna virus particles as shown by electron microscopy have been purified from the supernatant of cultured lymphocytes from bovine leukosis. In the purified C-particle fraction a DNA-polymerase activity was detected. Using several synthetic RNA-or DNA-homopolymers and 70S Friend virus RNA the template response of this bovine leukosis cell particle DNA polymerase was compared with those of feline leukaemia virus DNA polymerase and DNA polymerase from normal bovine lymphocytes. The DNA polymerase detected in the viral preparation of bovine leukosis is suggested to be an oncorna-virus-specific enzyme.

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