The Ligands of Low-Spin Ferric Compounds of Hemoglobin A1

Author(s):  
W. E. Blumberg ◽  
J. Peisach
Keyword(s):  
1984 ◽  
Vol 17 (3) ◽  
pp. 153-158
Author(s):  
Yoshinari Nomura ◽  
Kishio Nanjo ◽  
Motoshie Miyano ◽  
Kenichi Sakamoto ◽  
Kazuhiko Okai ◽  
...  

1981 ◽  
Vol 23 (2) ◽  
pp. 260-260
Author(s):  
Shigeki Miyamoto ◽  
Fumiko Nakamura ◽  
Nozomu Sasaki ◽  
Hiroo Niimi ◽  
Hironori Nakajima

2020 ◽  
Vol 27 (3) ◽  
pp. 159-162
Author(s):  
Marcus V. Ortega ◽  
Marie Bangura ◽  
Elnaz Ayati ◽  
Kaitlyn James ◽  
Caroline Mitchell ◽  
...  

Author(s):  
Rachel Blake ◽  
Chloe Zera

This chapter summarizes a landmark study on the association of first trimester hemoglobin A1 values with risk for spontaneous abortions and major fetal malformations during pregnancy in women with pregestational diabetes. Is there a correlation between glycemic control during the first trimester and risk for spontaneous abortion and major malformations? Starting with this question, it describes the basics of the study, including study location, study population, amount of patients, study design, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.


1983 ◽  
Vol 29 (7) ◽  
pp. 1444-1444
Author(s):  
M H Jonah ◽  
J S Krauss ◽  
P G Mohorn
Keyword(s):  

1982 ◽  
Vol 28 (1) ◽  
pp. 96-99 ◽  
Author(s):  
O Wålinder ◽  
G Ronquist ◽  
P J Fager

Abstract We compared a spectrophotometric kit method (Glycospec) for determination of glycosylated hemoglobin (HbA1) with a microcolumn kit method (Bio-Rad). The Glycospec method is based on the change in absorbance when phytic acid binds to hemoglobin A. With glycosylated hemoglobin there is no such change because the binding is blocked by the sugar moiety. Inter-assay CVs were 2-6% for both methods. In healthy subjects the mean (+/- SD) value for HbAl was about 1% higher with the spectrophotometric than the microcolumn method. For samples from 122 diabetics the correlation between values for HbAl obtained with the two methods was acceptable (r = 0.89), although the spectrophotometric technique yielded 2-4% higher values, a difference at least partly due to the absence of 2,3-diphosphoglycerate from the spectrophotometric standards. Adding 1.8 mmol of it per liter to these standards caused displacement of the standard curve; HbAl values then agreed well with those of the microcolumn method. The spectrophotometric procedure is easily automated, and therefore is well suited for large-scale analyses if problems with standards and calibration can be solved.


Teratology ◽  
1989 ◽  
Vol 39 (3) ◽  
pp. 225-231 ◽  
Author(s):  
Michael F. Greene ◽  
John W. Hare ◽  
John P. Cloherty ◽  
Beryl R. Benacerraf ◽  
J. Stuart Soeldner

Blood ◽  
1980 ◽  
Vol 56 (3) ◽  
pp. 571-572 ◽  
Author(s):  
C Tegos ◽  
E Beutler

Abstract Partially purified hemoglobin A2 has been examined for the existence of glycosylated components by isoelectric focusing and by acid agar gel electrophoresis. Bands analogous to the glycohemoglobin derivatives of hemoglobin A, hemoglobin-A1.a.b.c, were readily detected. Evidence that these minor bands are in fact glycohemoglobins was obtained by showing that 14C-glucose bound to hemoglobin A2 moved with these minor bands. The amounts of glycohemoglobin derivatives of hemoglobin A2 were increased in the blood of diabetic patients.


1987 ◽  
Vol 13 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Jacqueline Edelstein ◽  
Margaret W. Linn

Study participants were 120 diabetic men on insulin who completed Rotter's Locus of Control Scale. Control of diabetes was measured with a score derived from five-point weighted scales for hemoglobin A1, fasting blood glucose, triglyceride, and cholesterol. Baseline and six-month locus of control scores were correlated with metabolic control at six and 12 months. Results showed that an internal locus was associated with poorer control of the disease at six and 12 months, with correlations stronger at six months than at 12 months, when control was slightly worse. It may be that externally controlled individuals are more receptive to medical instructions and comply more readily than internal pa tients who take charge of their lives through self-controlling behaviors. A more thorough understanding of internally oriented diabetic patients is necessary to design educational programs that would guide these self-regulated persons toward better control of their illness.


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