Chapter VI Cutaneous Mastocytosis: Types and Lesions

2015 ◽  
pp. 18-54
Keyword(s):  
Cutaneous Mastocytosis

Two Pediatric Cases of Cutaneous Mastocytosis: Searching for a Mutation in the c-kit Gene

2009 ◽  
Vol 71 (5) ◽  
pp. 483-486
Author(s):  
Akemi TAKEMOTO ◽  
Michiya YAMAGUCHI ◽  
Yumiko HAGIYA ◽  
Masahiko MUTO
Keyword(s):  
Kit Gene ◽  
Cutaneous Mastocytosis

Interobserver variability in the classification of childhood maculopapular cutaneous mastocytosis

2021 ◽  
Author(s):  
Antonio Torrelo ◽  
Laura Vergara‐de‐la‐Campa ◽  
José Manuel Azaña ◽  
Shoshana Greenberger ◽  
Joseph M. Lam ◽  
...  
Keyword(s):  
Interobserver Variability ◽  
Cutaneous Mastocytosis

Serine proteinases in human cutaneous mastocytosis

1986 ◽  
Vol 278 (5) ◽  
pp. 363-366 ◽  
Author(s):  
J. E. Fr�ki ◽  
N. M. Schechter ◽  
G. S. Lazarus
Keyword(s):  
Serine Proteinases ◽  
Cutaneous Mastocytosis

Diffuse cutaneous mastocytosis in a newborn calf

2008 ◽  
Vol 19 (3) ◽  
pp. 184-186 ◽  
Author(s):  
Kiran S. Palyada ◽  
Danny W. Scott ◽  
Donald H. Schlafer ◽  
Melissa Czajkowski
Keyword(s):  
Cutaneous Mastocytosis

Cutaneous mastocytosis: demographic aspects and clinical features of 55 patients

2006 ◽  
Vol 0 (0) ◽  
pp. 060803064846002-??? ◽  
Author(s):  
G Akoglu ◽  
G Erkin ◽  
B Cakir ◽  
G Boztepe ◽  
S Sahin ◽  
...  
Keyword(s):  
Clinical Features ◽  
Cutaneous Mastocytosis

Anetoderma secondary to cutaneous mastocytosis: a rare occurrence?

2021 ◽  
Vol 156 (2) ◽  
Author(s):  
Irene LASTRUCCI ◽  
Vieri GRANDI ◽  
Federica SCARFÌ ◽  
Francesca PORTELLI ◽  
Nicola PIMPINELLI
Keyword(s):  
Rare Occurrence ◽  
Cutaneous Mastocytosis

Cutaneous Mastocytosis and Mucinosis with Gross Deformity in a Shar pei Dog

1992 ◽  
Vol 3 (4-5) ◽  
pp. 171-175 ◽  
Author(s):  
BRUCE R. MADEWELL ◽  
GEOFFREY Y. AKITA ◽  
PETER VOGEL
Keyword(s):  
Cutaneous Mastocytosis

scholarly journals Immune response against HtrA proteases in children with cutaneous mastocytosis

2018 ◽  
Vol 65 (3) ◽  
Author(s):  
Joanna Zofia Renke ◽  
Sabina Kędzierska-Mieszkowska ◽  
Magdalena Lange ◽  
Bogusław Nedoszytko ◽  
Anna Liberek ◽  
...  
Keyword(s):  
Mast Cells ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Children ◽  
Innate And Adaptive Immunity ◽  
Cellular Processes ◽  
Clonal Proliferation ◽  
Frequent Form ◽  
Cutaneous Mastocytosis ◽  
Igg Level

Mast cells play important role in both innate and adaptive immunity but clonal proliferation of abnormal mast cells in various organs leads to mastocytosis. The skin variant of the disease, cutaneous mastocytosis (CM) is the most frequent form of mastocytosis in children. The HtrA proteases are modulators of important cellular processes, including cell signaling and apoptosis, and are connected with development of many pathologies. The above and the observation that mast cells constitutively release the HtrA1 protein, prompted us to investigate a possible involvement of the HtrA proteins in pediatric CM.We assayed the levels of the serum autoantibodies (IgG) against the recombinant HtrA proteins (HtrA1-4) in children with CM (n= 36) and in healthy controls (n= 62). The anti-HtrA IgGs were detected using enzyme linked immunosorbent assay (ELISA) and Western-blotting. In the CM sera the levels of the anti-HtrA1 and anti-HtrA3 autoantibodies were significantly increased compared to the control group while the HtrA proteins’ levels were comparable. No significant differences in the anti-HtrA2 IgG level were found, and the anti-HtrA4 IgGs had a tendency to decrease. In healthy children, the IgG levels against the HtrA1, -3 and -4 increased significantly with the age of children; no significant changes were observed for the anti-HtrA2 IgG. Our results suggest involvement of the HtrA1 and HtrA3 proteins in pediatric CM; the involvement of the HtrA4 protein is possible but needs to be investigated further. In healthy children, the autoantibody levels against HtrA1, -3 and -4 but not against HtrA2 increase with age.

scholarly journals Place of cytology in the diagnosis of systemic mastocytosis: A case report

2021 ◽  
Vol 7 (2) ◽  
pp. 01-05
Author(s):  
W. Quiddi ◽  
H. Boumaazi ◽  
S. Ed-dyb ◽  
H. Yahyaoui ◽  
M. Aitameur ◽  
...  
Keyword(s):  
Mast Cells ◽  
Hematological Malignancies ◽  
Systemic Mastocytosis ◽  
Bone Marrow Involvement ◽  
Acute Leukemias ◽  
Activating Mutations ◽  
Myeloid Neoplasms ◽  
Organ Systems ◽  
Cutaneous Mastocytosis

Mastocytosis is a heterogeneous group of rare diseases related to the clonal, neoplastic proliferation of morphologically and immunophenotypically abnormal mast cells, that accumulate in one or more organ systems. Their pathophysiology is dominated by activating mutations in C-Kit (Stem Cell Factor receptor). Several pathological forms have been described ranging from isolated cutaneous mastocytosis affecting mainly children, to aggressive systemic mastocytosis described mainly in adults with bone marrow involvement. According to the WHO 2016 classification of hematological malignancies, systemic mastocytosis appear as a new entity of "myeloid neoplasms and acute leukemias" that combines cytology (abnormal mast cells) with other genetic and molecular criteria. We describe through this observation the practical side of hematological cytology in the diagnostic orientation of this serious, rare and underestimated pathology.

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