The Role of Sexual Hormones in Pattern Alopecia

2015 ◽  
pp. 50-60
Author(s):  
E. Ludwig
Keyword(s):  
Sexual Hormones

Stroke and Neuroinflamation: Role of Sexual Hormones

2016 ◽  
Vol 22 (10) ◽  
pp. 1334-1349 ◽  
Author(s):  
Maria Jose Perez-Alvarez ◽  
Francisco Wandosell
Keyword(s):  
Sexual Hormones

scholarly journals Role of miRNAs in Normal Endometrium and in Endometrial Disorders: Comprehensive Review

2021 ◽  
Vol 10 (16) ◽  
pp. 3457
Author(s):  
Kamila Kolanska ◽  
Sofiane Bendifallah ◽  
Geoffroy Canlorbe ◽  
Arsène Mekinian ◽  
Cyril Touboul ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Mirna Expression ◽  
Expression Patterns ◽  
Mirna Regulation ◽  
Rigorous Analysis ◽  
Sexual Hormones ◽  
Physiological Mechanisms ◽  
Normal Endometrium ◽  
Gynecological Disorders

The molecular responses to hormonal stimuli in the endometrium are modulated at the transcriptional and post-transcriptional stages. Any imbalance in cellular and molecular endometrial homeostasis may lead to gynecological disorders. MicroRNAs (miRNAs) are involved in a wide variety of physiological mechanisms and their expression patterns in the endometrium are currently attracting a lot of interest. miRNA regulation could be hormone dependent. Conversely, miRNAs could regulate the action of sexual hormones. Modifications to miRNA expression in pathological situations could either be a cause or a result of the existing pathology. The complexity of miRNA actions and the diversity of signaling pathways controlled by numerous miRNAs require rigorous analysis and findings need to be interpreted with caution. Alteration of miRNA expression in women with endometriosis has been reported. Thus, a potential diagnostic test supported by a specific miRNA signature could contribute to early diagnosis and a change in the therapeutic paradigm. Similarly, specific miRNA profile signatures are expected for RIF and endometrial cancer, with direct implications for associated therapies for RIF and adjuvant therapies for endometrial cancer. Advances in targeted therapies based on the regulation of miRNA expression are under evaluation.

scholarly journals Clinical Impact of Estradiol/Testosterone Ratio in Patients with Acute Ischemic Stroke

2020 ◽  
Author(s):  
Jung-Won Choi ◽  
In Woo Ryoo ◽  
Jun Yeong Hong ◽  
Kyung-Yul Lee ◽  
Hyo Suk Nam ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Sex Hormones ◽  
Control Group ◽  
Control Groups ◽  
Sexual Hormones ◽  
Stroke Group ◽  
Male Patients ◽  
And Control

Abstract Background: Sex hormones may be associated with a higher incidence of ischemic stroke or stroke-related events. In observational studies, lower testosterone concentrations are associated with infirmity, vascular disease, and adverse cardiovascular risk factors. Currently, female sexual hormones are considered neuroprotective agents. The purpose of this study was to assess the role of sex hormones and the ratio of estradiol/testosterone (E/T) in patients with acute ischemic stroke (AIS).Methods: Between January 2011 and December 2016, 146 male patients with AIS and 152 age- and sex-matched control subjects were included in this study. Sex hormones, including estradiol, progesterone, and testosterone, were evaluated in the AIS patient and control groups. We analyzed the clinical and physiological levels of sex hormones and hormone ratios in these patients.Results: The E/T ratio was significantly elevated among patients in the stroke group compared to those in the control group (P = 0.001). Categorization of data into tertiles revealed that patients with the highest E/T ratio were more likely to have AIS [odds ratio (OR) 3.084; 95% Confidence interval (CI): 1.616-5.886; P < 0.001) compared with those in the first tertile. The E/T ratio was also an independent unfavorable outcome predictor with an adjusted OR of 1.167 (95% CI: 1.053-1.294; P = 0.003).Conclusions: These findings support the hypothesis that increased estradiol and reduced testosterone levels are associated with AIS in men.

scholarly journals Analysis of the Role of Female Hormones During Infection by COVID-19

2021 ◽  
Vol 43 (12) ◽  
pp. 940-948
Author(s):  
David Balbino Pascoal ◽  
Isabela Macêdo de Araujo ◽  
Lorenna Peixoto Lopes ◽  
Cristiane Monteiro da Cruz
Keyword(s):  
Relative Risk ◽  
Adverse Effects ◽  
Data Sources ◽  
Hormonal Contraceptives ◽  
Review Of The Literature ◽  
Sexual Hormones ◽  
Auxiliary Data ◽  
The World ◽  
Coronavirus Infection

AbstractWomen have metabolic, immunological, and genetic variables that ensure more protection from coronavirus infection. However, the indication of treatment for several pathologies and contraception is determined by hormones that have adverse effects and raise doubts about their use during the COVID-19 pandemic. Therefore, the present study searches women specificities and the relation between female sexual hormones and COVID-19, and reports the main recommendations in this background. To this end, a review of the literature was conducted in the main databases, auxiliary data sources, and official websites. Therefore, considering the hypercoagulability status of COVID-19, the debate about the use of contraceptives due to the relative risk of thromboembolic effects that they impose arises. However, the current available evidence, as well as the recommendations of main health organs around the world, demonstrate that the use of hormonal contraceptives must be maintained during the pandemic.

scholarly journals Relationships between the blood cells, sexual hormones and lipid peroxidation in women with essential hypertension

2019 ◽  
pp. 39-47
Author(s):  
Б.И. Кузник ◽  
Ю.Н. Смоляков ◽  
С.О. Давыдов ◽  
Е.С. Гусева ◽  
М.В. Максименя
Keyword(s):  
Lipid Peroxidation ◽  
Essential Hypertension ◽  
Blood Cells ◽  
Heart Function ◽  
Sexual Hormones ◽  
Healthy Women ◽  
Positive Correlations ◽  
Almost All ◽  
Rbc Count

У женщин, больных гипертонической болезнью, существуют тесные корреляционные взаимосвязи между различными форменными элементами крови и уровнем артериального давления, показателями деятельности сердца, тестами, характеризующими состояние гемодинамики, тромбодинамики и коагуляционной активности крови. Цель исследования - изучение роли различных форменных элементов крови и их соотношения в регуляции уровня эстрогена, прогестерона и пролактина, ТБК-активных продуктов и антиоксидантной активности у больных гипертонической болезнью. Методика. Исследования проведены на 72 больных гипертонической болезнью, контрольную группу составили 12 женщин с нормальным артериальным давлением. Больные были разделены на 2 группы: в 1-ю группу вошли 37 пациенток с гипертонической болезнью II стадии, находящиеся на гипотензивной терапии, 2-ю - составили 35 женщин с гипертонией II стадии, которые кроме медикаментозного лечения, регулярно проходили курсы кинезотерапии на протяжении 2-3 лет. Результаты. Методом корреляционного анализа установлено, что у здоровых женщин и больных гипертонической болезнью, изучаемые взаимосвязи могут носить как однонаправленный, так и разнонаправленный характер. У здоровых женщин обнаруживается прямая связь между количеством лимфоцитов и уровнем прогестерона и обратная - с уровнем пролактина. Прямая связь также выявлена между индексом нейтрофилы/базофилы и прогестероном. При гипертонии у больных 1-й группы обнаруживается прямая связь между количеством эритроцитов и прогестероном, числом эозинофилов и пролактином; индекса лимфоциты/эозинофилы с эстрадиолом; индексов нейтрофилы/моноциты, нейтрофилы/базофилы и лимфоциты/базофилы с прогестероном. Отрицательная корреляция выявляется между индексами нейтрофилы/лимфоциты и нейтрофилы/эозинофилы с пролактином. У больных 2-й группы обнаружены прямые корреляционные связи между абсолютным количеством лейкоцитов, нейтрофилов и эозинофилов и отрицательная связь индекса эритроциты/лейкоциты с пролактином. При оценке корреляционных взаимосвязей показателей крови с показателями активности оксидантно/антиоксидантной системы показано, что у здоровых женщин существуют положительные связи между числом моноцитов с содержанием ТБК-продуктов и активностью антиоксидантной системы; эозинофилов с активностью антиоксидантной системы; индекса лейкоциты/тромбоциты с уровнем ТБК-продуктов. При гипертонической болезни в группе без кинезотерапии (1-я группа) выявлена отрицательная взаимосвязь между общим числом эритроцитов и показателями активности антиоксидантной системы. Заключение. Практически все форменные элементы крови и различные их взаимоотношения у здоровых и больных гипертонической болезнью играют существенную роль в регуляции уровня эстрадиола, прогестерона, пролактина и состояния системы перекисного окисления липидов - антиоксидантная активность. Close correlations exist between different blood cells (BC), blood pressure, heart function, results of hemodynamics tests, thrombodynamics, and blood coagulation in women with hypertension. Aim. The study addressed the role of different BCs and their combinations in regulation of estrogen, progesterone, prolactin, TBA-reactive substances (TBARS), and antioxidant activity (AOA) in hypertensive patients. Methods. The study included 12 healthy women (control) and 72 patients with essential hypertension (EH). Patients with EH were divided into two groups; the first group (EH-1) consisted of 37 women with stage II EH receiving an antihypertensive therapy and the second group (EH-2) consisted of 35 women who, in addition to the drug therapy, yearly underwent 3-4 courses of kinesitherapy for 2-3 year on a regular basis. Results. Both in healthy women and patients of the EH-1 and EH-2 groups, the studied relationships were either positive or negative. In healthy women, LYM positively correlated with progesterone and inversely correlated with prolactin, and the NEU/BAS ratio positively correlated with progesterone. In patients of the EH-1 group, there were positive correlations of RBC with progesterone; EOS with prolactin; and LYM/EOS with estradiol; and NEU/MON, NEU/BAS, and LYM/BAS with progesterone. The NEU/LYM and NEU/EOS ratios inversely correlated with prolactin. In patients of the EH-2 group, there were positive correlations of WBC, NEU, and EOS with prolactin and inverse correlations of the RBC/WBC ratio with prolactin. Evaluation of correlations between blood indexes and the oxidant/antioxidant system showed that in healthy women, there were positive correlations of the MON count with TBARS and AOA; EOS with AOA; and the WBC/PLT ratio with TBARS. Patients of the EH-1 group showed a negative correlation of the total RBC count with AOA. Conclusion. In both healthy subjects and EH groups, almost all BCs and their relationships play a significant role in regulation of estradiol, progesterone, prolactin, and the lipid peroxidation/AOA system.

scholarly journals The Role of Estrogens in Rheumatoid Arthritis Physiopathology

2020 ◽  
Author(s):  
Maria Fernanda Romo-García ◽  
Martín Zapata-Zuñiga ◽  
José Antonio Enciso-Moreno ◽  
Julio Enrique Castañeda-Delgado
Keyword(s):  
Rheumatoid Arthritis ◽  
Direct Action ◽  
Hormone Replacement ◽  
Joint Disease ◽  
Dependent Manner ◽  
Sexual Hormones ◽  
Dose Dependent ◽  
Estrogen Administration

Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease that can lead to irreversible disability. It affects women in a higher proportion than men (3:1 cases). Several reports suggest a link between female sexual hormones (estrogens) and RA features. It’s been described that biological processes where basal estrogen levels are altered like in menstruation, pregnancy, and menopause modifies RA onset, flare, disease severity, and inflammation. Estrogens have a direct action upon the immune system though ERα and ERβ receptors, which have distinct affinity to estrogen concentrations and modifications and have effects upon RA in a dose and receptor dependent manner. The studies focused on dose dependent response at experimental settings reveal a wide (from 25 pg/L to several μg/L) and even contradictory spectrum of effects in patients and cells. This chapter summarizes the contributions and effects of estrogens in RA physiopathology, clinical features, and discusses the possible contributions of estrogen administration and concentration of hormone replacement therapy (HRT) to improve the quality of life and reduce the symptoms of RA patients based on the knowledge of the biology of these hormones.

scholarly journals The Role of Sexual Hormones on the Enteroinsular Axis

2019 ◽  
Vol 40 (4) ◽  
pp. 1152-1162 ◽  
Author(s):  
Sandra Handgraaf ◽  
Jacques Philippe
Keyword(s):  
Sex Hormones ◽  
Glucose Homeostasis ◽  
Fine Tuning ◽  
Protective Effects ◽  
Enteroinsular Axis ◽  
Sexual Hormones ◽  
The Impact ◽  
Potential Therapeutics

AbstractSex steroid estrogens, androgens, and progesterone, produced by the gonads, which have long been considered as endocrine glands, are implicated in sexual differentiation, puberty, and reproduction. However, the impact of sex hormones goes beyond these effects through their role on energy metabolism. Indeed, sex hormones are important physiological regulators of glucose homeostasis and, in particular, of the enteroinsular axis. In this review, we describe the roles of estrogens, androgens, and progesterone on glucose homeostasis through their effects on pancreatic α- and β-cells, as well as on enteroendocrine L-cells, and their implications in hormonal biosynthesis and secretion. The analysis of their mechanisms of action with the dissection of the receptors implicated in the several protective effects could provide some new aspects of the fine-tuning of hormonal secretion under the influence of the sex. This knowledge paves the way to the understanding of transgender physiology and new potential therapeutics in the field of type 2 diabetes.

scholarly journals Traumatic Brain Injury and the Gastrointestinal Tract: The Role of Female Sexual Hormones

2017 ◽  
Vol 7 (6) ◽  
pp. 163-171
Author(s):  
Zakieh Keshavarzi ◽  
Amir R. Afshari ◽  
Nasibeh Mohammadzadeh ◽  
Masoud Mohebbi ◽  
Moein Mohebbi ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Gastrointestinal Tract ◽  
Brain Injury ◽  
Sexual Hormones

scholarly journals Investigation the effects of varicocelectomy on sex hormones levels and semen parameters

2021 ◽  
Vol 6 (2) ◽  
pp. 07-013
Author(s):  
Fatemeh Soheili ◽  
Mohamad Falahati
Keyword(s):  
Surgical Intervention ◽  
Sperm Count ◽  
Cross Sectional Study ◽  
Semen Parameters ◽  
Sexual Disorders ◽  
Sexual Hormones ◽  
Cross Sectional ◽  
Fertility Potential ◽  
Positive Effect

Background: Varicocelectomy is a type of surgery for varicocele treatment. This may recover fertility properties in males through improvement in semen parameters as well as sexual hormones. In this study, the role of varicocelectomy with focus on semen properties and sexual hormones have been assessed. Methods: In this cross-sectional study, before- after data from fifteen patients with different varicocele grade, regarding to varicocelectomy have been compared. Result: After varicocelectomy, a significant improvement in some semen parameters such as motility and concentration has been showed. However, among sexual hormones, only testosterone has been increased after surgical intervention (p=0.007). Conclusion: Based on our knowledge, varicocele treatment may almost improve fertility potential in males significantly. Accordingly, it seems that varicocelectomy has positive effect on parameters such as testosterone and serum FSH levels as well as sperm count and motility. Therefore, it could be concluded that varicocelectomy is an effective approach to improve male fertility and sexual disorders.

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