Cytotoxicity of Lymphocytes and its Suppression

2015 ◽  
pp. 295-309 ◽  
Author(s):  
G. Holm ◽  
P. Perlmann
Keyword(s):  
Cytotoxicity Of Lymphocytes

Studies on the Cytotoxicity of Lymphocytes

1969 ◽  
pp. 113-121
Author(s):  
H. Fischer ◽  
W. Ax ◽  
H. Malchow ◽  
I. Zeiss
Keyword(s):  
Cytotoxicity Of Lymphocytes

scholarly journals EGFR-TKI resistance promotes immune escape in lung cancer via increased PD-L1 expression

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Shunli Peng ◽  
Rong Wang ◽  
Xiaojuan Zhang ◽  
Yueyun Ma ◽  
Longhui Zhong ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Immune Escape ◽  
Objective Response ◽  
Tki Resistance ◽  
Before And After ◽  
Cytotoxicity Of Lymphocytes ◽  
Egfr Tki ◽  
Egfr T790m ◽  
Egfr Tkis

Abstract Background The ATLANTIC trial reported that higher PD-L1 expression in tumors was involved in a higher objective response in patients with EGFR+/ALK+ non-small cell lung cancer (NSCLC), indicating the possibility of anti-PD-1/PD-L1 therapy as a third-line (or later) treatment for advanced NSCLC. Therefore, the determination of status and regulatory mechanisms of PD-L1 in EGFR mutant NSCLC before and after acquired EGFR-TKIs resistance are meaningful. Methods The correlation among PD-L1, c-MET, and HGF was analyzed based on TCGA datasheets and paired NSCLC specimens before and after acquired EGFR-TKI resistance. EGFR-TKI resistant NSCLC cells with three well-known mechanisms, c-MET amplification, hepatocyte growth factor (HGF), and EGFR-T790M, were investigated to determinate PD-L1 expression status and immune escape ability. PD-L1-deleted EGFR-TKIs sensitive and resistant cells were used to evaluate the immune escape ability of tumors in mice xenograft models. Results Positive correlations were found among PD-L1, c-MET, and HGF, based on TCGA datasheets and paired NSCLC specimens. Moreover, the above three resistant mechanisms increased PD-L1 expression and attenuated activation and cytotoxicity of lymphocytes in vitro and in vivo, and downregulation of PD-L1 partially restored the cytotoxicity of lymphocytes. Both MAPK and PI3K pathways were involved in the three types of resistance mechanism-induced PD-L1 overexpression, whereas the NF-kappa B pathway was only involved in T790M-induced PD-L1 expression. Conclusions HGF, MET-amplification, and EGFR-T790M upregulate PD-L1 expression in NSCLC and promote the immune escape of tumor cells through different mechanisms.

Impaired cytotoxicity of lymphocytes from patients with cancer

1976 ◽  
Vol 8 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Nicole Suciu-Foca ◽  
Joseph A. Buda ◽  
Frederic Herter ◽  
Anthony Molinaro ◽  
John Broell ◽  
...  
Keyword(s):  
Patients With Cancer ◽  
Cytotoxicity Of Lymphocytes
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