scholarly journals Experimental Carcinoma of the Endometrium

2015 ◽  
pp. 192-260 ◽  
Author(s):  
Nobuhisa Baba ◽  
Emmerich von Haam
Keyword(s):  
Experimental Carcinoma

Reprogrammed M1 macrophages with inhibited STAT3, STAT6 and/or SMAD3 extends lifespan of mice with experimental carcinoma

2017 ◽  
pp. 4-9
Author(s):  
С.В. Калиш ◽  
С.В. Лямина ◽  
А.А. Раецкая ◽  
И.Ю. Малышев
Keyword(s):  
Tumor Growth ◽  
Culture Medium ◽  
Ehrlich Carcinoma ◽  
Macrophage Phenotype ◽  
M1 Macrophages ◽  
M1 Macrophage ◽  
Ec Cells ◽  
Experimental Carcinoma

Цель исследования. Репрограммирование М1 фенотипа макрофагов с ингибированными факторами транскрипции М2 фенотипа STAT3, STAТ6 и SMAD и оценка их влияния на развитие карциномы Эрлиха (КЭ) in vitro и in vivo. Методика. Рост опухоли иницировали in vitro путем добавления клеток КЭ в среду культивирования RPMI-1640 и in vivo путем внутрибрюшинной инъекции клеток КЭ мышам. Результаты. Установлено, что M1макрофаги и in vitro, и in vivo оказывают выраженный противоопухолевый эффект, который превосходит антиопухолевые эффекты М1, M1, M1 макрофагов и цисплатина. Заключение. М1 макрофаги с ингибированными STAT3, STAT6 и/или SMAD3 эффективно ограничивают рост опухоли. Полученные данные обосновывают разработку новой технологии противоопухолевой клеточной терапии. Objective. Reprogramming of M1 macrophage phenotype with inhibited M2 phenotype transcription factors, such as STAT3, STAT6 and SMAD and assess their impact on the development of Ehrlich carcinoma (EC) in vitro and in vivo . Methods. Tumor growth in vitro was initiated by addition of EC cells in RPMI-1640 culture medium and in vivo by intraperitoneal of EC cell injection into mice. Results. It was found that M1 macrophages have a pronounced anti-tumor effect in vitro , and in vivo , which was greater than anti-tumor effects of M1, M1, M1 macrophages and cisplatin. Conclusion. M1 macrophages with inhibited STAT3, STAT6 and/or SMAD3 effectively restrict tumor growth. The findings justify the development of new anti-tumor cell therapy technology.

scholarly journals Combined Anti-Angiogenic Therapy Targeting PDGF and VEGF Receptors Lowers the Interstitial Fluid Pressure in a Murine Experimental Carcinoma

PLoS ONE ◽  
2009 ◽  
Vol 4 (12) ◽  
pp. e8149 ◽  
Author(s):  
Agnieszka Kłosowska-Wardęga ◽  
Yoko Hasumi ◽  
Mikhail Burmakin ◽  
Aive Åhgren ◽  
Linda Stuhr ◽  
...  
Keyword(s):  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure ◽  
Vegf Receptors ◽  
Angiogenic Therapy ◽  
Experimental Carcinoma

Experimental carcinoma of the biliary tract induced in dogs by N-ethyl-N’-nitro-N-nitrosoguanidine

1977 ◽  
Vol 12 (2) ◽  
pp. 47-50 ◽  
Author(s):  
Saburo Nakazawa ◽  
Yasuo Naito ◽  
Yoshiki Yamamoto ◽  
Hiroshiko Yamase ◽  
Kunio Sobue ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Experimental Carcinoma

scholarly journals Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma

2007 ◽  
Vol 104 (35) ◽  
pp. 13966-13971 ◽  
Author(s):  
A. Oldberg ◽  
S. Kalamajski ◽  
A. V. Salnikov ◽  
L. Stuhr ◽  
M. Morgelin ◽  
...  
Keyword(s):  
Fluid Balance ◽  
Matrix Structure ◽  
Collagen Binding ◽  
Experimental Carcinoma

scholarly journals Inhibition of TGF-β modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma

2005 ◽  
Vol 85 (4) ◽  
pp. 512-521 ◽  
Author(s):  
Alexei V Salnikov ◽  
Pernilla Roswall ◽  
Christian Sundberg ◽  
Humphrey Gardner ◽  
Nils-Erik Heldin ◽  
...  
Keyword(s):  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure ◽  
Vessel Maturation ◽  
Experimental Carcinoma
Sign in / Sign up

Export Citation Format

Share Document