Is There a Measurable Difference between the Left and Right Modified Myocardial Performance Indices, and Does This Change to Reflect Unilateral Myocardial Dysfunction in Pathology?

2015 ◽  
Vol 38 (4) ◽  
pp. 288-295 ◽  
Author(s):  
Alec W. Welsh ◽  
Amanda Henry ◽  
Neama Meriki ◽  
Aditi Mahajan ◽  
Linda Wu ◽  
...  
Keyword(s):  
Myocardial Dysfunction ◽  
Cross Sectional Study ◽  
Myocardial Performance ◽  
Performance Indices ◽  
Cross Sectional ◽  
Pilot Data ◽  
Design Function ◽  
Left And Right ◽  
First Time ◽  
Twin Pregnancies

Introduction: Fetal cardiac dysfunction may manifest itself unilaterally as right and left ventricles differing in design, function and load, measurable as differing in myocardial performance indices (MPIs). We wished to define this difference (‘delta-MPI' or DMPI), present its normal range and pilot its use in pathological pregnancy. Material and Methods: Prospective cross-sectional study of 324 normal singleton fetuses (16-38 weeks of gestation). Left and right modified MPI (LMPI and RMPI) were performed during a single examination using the ‘peak' valve click technique. Thirty-seven pathological singleton and monochorionic diamniotic twin pregnancies were compared as pilot data. Results: Modified MPIs (mean ± SD) were 0.45 ± 0.06 (LMPI) and 0.47 ± 0.09 (RMPI), being similar at 18 weeks' gestation with DMPI increasing slightly throughout pregnancy (0.02 ± 0.08). Both singleton intrauterine growth restriction (IUGR) and recipient twin-twin transfusion syndrome (TTTS) showed significantly elevated RMPI, LMPI and DMPI, most pronounced for DMPI (450 and 500% increase, respectively; p < 0.01). DMPI acquisition rates were 83.3% normal and 87.0% pathological. Discussion: We demonstrate for the first time differing intrafetal LMPI and RMPI in a large gestational cohort, with this difference increasing with gestational age. Pilot data confirm the potential for DMPI as a tool to assess unilateral myocardial function in singleton IUGR and recipient twins in TTTS, and further studies are under way to evaluate its clinical utility.

scholarly journals Mandibular range of motion in children with juvenile idiopathic arthritis with and without clinically established temporomandibular joint involvement and in healthy children; a cross-sectional study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Willemijn F. C. de Sonnaville ◽  
Caroline M. Speksnijder ◽  
Nicolaas P. A. Zuithoff ◽  
Daan R. C. Verkouteren ◽  
Nico W. Wulffraat ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Range Of Motion ◽  
Temporomandibular Joint ◽  
Cross Sectional Study ◽  
Joint Involvement ◽  
Healthy Children ◽  
Sectional Study ◽  
Cross Sectional ◽  
Explanatory Factors ◽  
Left And Right

Abstract Background Recognition of temporomandibular joint (TMJ) involvement in children with juvenile idiopathic arthritis (JIA) has gained increasing attention in the past decade. The clinical assessment of mandibular range of motion characteristics is part of the recommended variables to detect TMJ involvement in children with JIA. The aim of this study was to explore explanatory variables for mandibular range of motion outcomes in children with JIA, with and without clinically established TMJ involvement, and in healthy children. Methods This cross-sectional study included children with JIA and healthy children of age 6–18 years. Mandibular range of motion variables included active and passive maximum interincisal opening (AMIO and PMIO), protrusion, laterotrusion, dental midline shift in AMIO and in protrusion. Additionally, the TMJ screening protocol and palpation pain were assessed. Adjusted linear regression analyses of AMIO, PMIO, protrusion, and laterotrusion were performed to evaluate the explanatory factors. Two adjusted models were constructed: model 1 to compare children with JIA and healthy children, and model 2 to compare children with JIA with and without TMJ involvement. Results A total of 298 children with JIA and 169 healthy children were included. Length was an explanatory variable for the mandibular range of motion excursions. Each centimeter increase in length increased AMIO (0.14 mm), PMIO (0.14 mm), and protrusion (0.02 mm). Male gender increased AMIO by 1.35 mm. Having JIA negatively influenced AMIO (3.57 mm), PMIO (3.71 mm), and protrusion (1.03 mm) compared with healthy children, while the discrepancy between left and right laterotrusion raised 0.68 mm. Children with JIA and TMJ involvement had a 8.27 mm lower AMIO, 7.68 mm lower PMIO and 0.96 mm higher discrepancy in left and right laterotrusion compared to healthy children. Conclusion All mandibular range of motion items were restricted in children with JIA compared with healthy children. In children with JIA and TMJ involvement, AMIO, PMIO and the discrepancy between left and right laterotrusion were impaired more severely. The limitation in protrusion and laterotrusion was hardly clinically relevant. Overall, AMIO is the mandibular range of motion variable with the highest restriction (in millimeters) in children with JIA and clinically established TMJ involvement compared to healthy children.

scholarly journals Viral Profiling Identifies Multiple Subtypes of Kaposi’s Sarcoma

mBio ◽  
2014 ◽  
Vol 5 (5) ◽  
Author(s):  
Mina C. Hosseinipour ◽  
Kristen M. Sweet ◽  
Jie Xiong ◽  
Dan Namarika ◽  
Albert Mwafongo ◽  
...  
Keyword(s):  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Complete Information ◽  
The United States ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Reading Frame ◽  
Real Time Quantitative Pcr ◽  
Treatment Naïve ◽  
First Time

ABSTRACTKaposi’s sarcoma (KS), caused by KS-associated herpesvirus (KSHV), is the most common cancer among HIV-infected patients in Malawi and in the United States today. In Malawi, KSHV is endemic. We conducted a cross-sectional study of patients with HIV infection and KS with no history of chemo- or antiretroviral therapy (ART). Seventy patients were enrolled. Eighty-one percent had T1 (advanced) KS. Median CD4 and HIV RNA levels were 181 cells/mm3and 138,641 copies/ml, respectively. We had complete information and suitable plasma and biopsy samples for 66 patients. For 59/66 (89%) patients, a detectable KSHV load was found in plasma (median, 2,291 copies/ml; interquartile range [IQR], 741 to 5,623). We utilized a novel KSHV real-time quantitative PCR (qPCR) array with multiple primers per open reading frame to examine KSHV transcription. Seventeen samples exhibited only minimal levels of KSHV mRNAs, presumably due to the limited number of infected cells. For all other biopsy samples, the viral latency locus (LANA, vCyc, vFLIP, kaposin, and microRNAs [miRNAs]) was transcribed abundantly, as was K15 mRNA. We could identify two subtypes of treatment-naive KS: lesions that transcribed viral RNAs across the length of the viral genome and lesions that displayed only limited transcription restricted to the latency locus. This finding demonstrates for the first time the existence of multiple subtypes of KS lesions in HIV- and KS-treatment naive patients.IMPORTANCEKS is the leading cancer in people infected with HIV worldwide and is causally linked to KSHV infection. Using viral transcription profiling, we have demonstrated the existence of multiple subtypes of KS lesions for the first time in HIV- and KS-treatment-naive patients. A substantial number of lesions transcribe mRNAs which encode the viral kinases and hence could be targeted by the antiviral drugs ganciclovir or AZT in addition to chemotherapy.

scholarly journals Fetal Biparietal Diameter and Abdominal Circumference Ratio in Bangladesh

1970 ◽  
Vol 39 (1) ◽  
pp. 24-27
Author(s):  
Sabrina Q Rashid
Keyword(s):  
Polynomial Regression ◽  
Cross Sectional Study ◽  
Abdominal Circumference ◽  
Accurate Assessment ◽  
Sectional Study ◽  
Cross Sectional ◽  
Biparietal Diameter ◽  
First Time ◽  
Polynomial Regression Model ◽  
Growth Abnormality

This study was conducted to determine fetal biparietal diameter and abdominal circumference ratio in Bangladesh. There is still no table of this ratio in our country. A prospective, cross-sectional study was conducted on well dated, singleton fetuses of healthy pregnant women. One table and two graphs were prepared by fitting Polynomial regression model. Percentiles, mean and two standard deviations were derived of the ratio. Fetal charts of the raw data with superimposed fitted curves were constructed. The model showed a good fit to the data of 1223 subjects. It covered 95% of the population and gave 3rd, 10th, 50th, 90th and 97th percentiles. This chart can be useful for accurate assessment of fetal biparietal diameter and abdominal circumference ratio to determine the type of fetal growth abnormality, symmetrical or asymmetrical. This is the first time that this ratio has been studied in Bangladesh. Key words: Biparietal diameter; abdominal circumference. DOI: 10.3329/bmj.v39i1.6229 Bangladesh Medical Journal 2010; 39(1): 24-27

Determination of the Problems Experienced by Patients Post-Thyroidectomy

2017 ◽  
Vol 28 (5) ◽  
pp. 615-635
Author(s):  
Semra Atasayar ◽  
Sevil Guler Demir
Keyword(s):  
Postoperative Period ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Telephone Interviews ◽  
Two Stages ◽  
First Time ◽  
Benign Thyroid

This descriptive, cross-sectional study investigated problems experienced by patients after undergoing a thyroidectomy. The study included 60 first-time, post-thyroidectomy patients diagnosed with benign thyroid disease from a university hospital’s general surgery clinic in Ankara, Turkey. The data were collected in two stages: interviews with patients on the first day following surgery and postoperative follow-up telephone interviews in each of the first 4 weeks following surgery. The follow-ups revealed that patients principally experienced varying degrees of pain and difficulties in connection with work and recreation, communication, body image, and movement, for up to 4 weeks after surgery. These results showed that patients were particularly prone to problems on the first day and during the first week of the postoperative period; therefore, patients should be provided with follow-up telephone interviews to facilitate easier recovery and to help them overcome any problems experienced during the postoperative period.

scholarly journals A National Survey of Community Pharmacists on Smoking Cessation Services in Thailand

Pharmacy ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 101 ◽  
Author(s):  
Surarong Chinwong ◽  
Dujrudee Chinwong
Keyword(s):  
Smoking Cessation ◽  
Community Pharmacists ◽  
Cross Sectional Study ◽  
Postal Questionnaire ◽  
Pharmaceutical Product ◽  
Perceived Barriers ◽  
Cross Sectional ◽  
Smoking Cessation Services ◽  
First Time

Providing smoking cessation services is one role of community pharmacists in Thailand. This cross-sectional study aimed to investigate activities and barriers related to smoking cessation services provided in community pharmacies in Thailand, as well as to compare these activities and barriers between those pharmacists providing and those not providing smoking cessation services. A postal questionnaire was conducted to collect information from community pharmacists across Thailand. In all, 413 valid responses were received from 5235 questionnaires, giving a 7.9% response rate. Of the 413 respondents, 152 (37%) pharmacists provided smoking cessation services in their pharmacy. The activities of smoking cessation services varied. Time for counseling each smoker varied, a mean of 15.1 ± 10.9 min (range 1–60) per person for the first time, and 8.9 ± 6.7 min (range 1–30) for each follow-up visit. Community pharmacists, providing smoking cessation services, were more likely to have pharmacist assistants, be a member of the Thai Pharmacy Network for Tobacco Control, and have more than 1 pharmacist on duty. The most dispensed pharmaceutical product for smoking cessation was nicotine gum. Their most perceived barriers were being unable to follow-up and inadequate staff. In conclusion, only a minority of community pharmacists in Thailand are engaged in smoking cessation activities, even though some perceived barriers existed.

scholarly journals Personality profile of team handball referees at expert level

2021 ◽  
Author(s):  
Marcus Dodt ◽  
Frowin Fasold ◽  
Daniel Memmert
Keyword(s):  
National Level ◽  
Cross Sectional Study ◽  
Negative Emotionality ◽  
Personality Profiles ◽  
Game Management ◽  
Cultural Backgrounds ◽  
Cross Sectional ◽  
Team Handball ◽  
Standard Values ◽  
First Time

AbstractReferees play a central role in every sport. Particularly at national level, referees must meet ever higher demands due to increasing professionalisation. While cognitive and conditional aspects have already been investigated intensively, personality traits of handball referees have so far only received little attention. In addition to a profound understanding of the game and knowledge of the rules, however, it is precisely the demands on referees’ personalities that are becoming increasingly important. Individual differences in personality are related to job performance in sports, especially with regard to coping with pressure and stress. Thus, personality is considered an essential component of the performance profile of referees and is required in the context of efficient game management. In this study, the personality profiles of male handball referees at expert level (N = 163) were examined for the first time, using the German version of the Big Five Inventory 2 (BFI-2). Standard values of the German general population from a population survey were used for comparison. Referees scored higher values in extraversion, agreeableness, and conscientiousness and a lower value in negative emotionality. The results of this cross-sectional study provide initial insights into the personality of this group of referees and thus lay the foundation for further research. A study with referees from different performance levels or cultural backgrounds could provide information on whether the results of this study only apply to German handball referees at expert level or are valid for all handball referees.

scholarly journals Contraception and Sexsual Activity as Factor Influenced Leucorrhea

2017 ◽  
Vol 5 (3) ◽  
pp. 371
Author(s):  
Sari Priyanti
Keyword(s):  
Hormonal Contraception ◽  
Cross Sectional Study ◽  
Childbearing Age ◽  
Cross Sectional ◽  
The Public ◽  
First Sexual Intercourse ◽  
Number Of Children ◽  
Study Population ◽  
The Impact ◽  
First Time

ABSTRACTCervical cancer was non communicable desease that worries the public and causes an increase mortality in women. One of the first sign causes of cervical cancer is occourrence of Leucorrhoe. The incidence of Leucorrhoe in women Indonesia by 90% of which >75% of women experience once of leucorrhoe and experience ≥ 2 times by 25%. Leucorrhoe should not be considered an ordinary thing because can be caused to itchy on genetalia, pain during sexsual, infection  can be caused odema on genetalia, hot like burned on vagina even the impact if not treated promptly will caused infertility and cancer. Aims of study was to analyze factors of influenced on Leucorrhoe incident. Design of study was cross sectional study. Population was women of childbearing age who use contraceptives in the karang jeruk village, Jatirejo sub district, Mojokerto district in March of 2017. Sample in this study was 33 people. Data analyze with logistic regresion. Result of study showed contraceptive and sexsual activity has significant influenced with leucorrhoe (PR = 10.000; 95% CI= 1,732-57,722 dan PR=8,750; 95% CI=1,466-52,232). Suggestion: should be married and have first sexual intercourse for the first time at the age of  ≥ 20 years, limit the number of children not more than 2 as the greater the number of children the greater the risk of Leucorrhoe, and not using hormonal contraception for a along time that more than 2 years. Keywords: contraceptive,sexsual activity, leucorrhoe

scholarly journals Four Year Results of Conservative Treatment of Benign Strictures of the Esophagus with Savary Gilliard Technique of Bougienage: Cross-Sectional Study Representing First Experiences in Republic of Macedonia

PRILOZI ◽  
2018 ◽  
Vol 39 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Vladimir Andreevski ◽  
Gorgi Deriban ◽  
Urim Isahi ◽  
Jane Mishevski ◽  
Magdalena Dimitrova ◽  
...  
Keyword(s):  
Therapeutic Response ◽  
Cross Sectional Study ◽  
Esophageal Stenosis ◽  
Optimal Timing ◽  
Cross Sectional ◽  
Republic Of Macedonia ◽  
Peptic Stenosis ◽  
Esophageal Strictures ◽  
The University ◽  
First Time

Abstract Background: Benign esophageal strictures are complications resulting from various causes. They can be structurally categorized in two groups: simple and complex. Treatment is similar in most cases that require dilatation and means use of three general types of dilators that are currently in use. However, despite the last guidelines on esophageal dilatation, the therapeutic response, optimal timing of treatment and interval between sessions may vary and there is no strong consensus in the literature regarding this fact. Aims: To analyzethe first 4 year experience of Digestive Endoscopy Unit at the University Clinic of Gastroenterohepatology of the Medical Faculty, Skopje, Republic of Macedonia in treating benign esophageal strictures, since the Savary-Gilliard technique of “bougienage” was introduced for the first time in Republic of Macedonia, at our Institution, in December 2013, by assessing etiology, length of stricture, number of dilations required to achieve satisfactory therapeutic response, as well as the relationship between the type, extent of stenosis and therapeutic response. Methods: One hundred and forty five dilations, during a period from 20th December 2013, until March 2017, have been analyzed in 31 patients Results: The caustic strictures were the most prevalent, occurring in 15 (48%) of patients, followed by peptic stenosis presenting 26% of patients. The long and corrosive strictures needed more sessions to the absence of dysphagia. Peptic and short stenoses best respondedon treatment and needed fewer dilatation sessions per patient. Conclusion: Caustic stricture is the most common type of benign esophageal stenosis and the most refractory to treatment, especially the long one. Peptic stenosis is the second cause of benign esophageal strictures and responded well to endoscopic therapy. The higher the extent of stenosis, the greater the number of sessions required. Short strictures have good prognoses in most cases. The number of dilations depended directly on the cause and extent of stenosis. Bouginage using Savary-Gilliard or American type of technique, irrespective of the type and the extent of esophageal stenosis, is safe and purposeful procedure.

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