scholarly journals Evidence that Neurokinin B Controls Basal Gonadotropin-Releasing Hormone Secretion but Is Not Critical for Estrogen-Positive Feedback in Sheep

2015 ◽  
Vol 101 (2) ◽  
pp. 161-174 ◽  
Author(s):  
Qun Li ◽  
Robert P. Millar ◽  
Iain J. Clarke ◽  
Jeremy T. Smith
Keyword(s):  
Positive Feedback ◽  
Hormone Secretion ◽  
Gonadotropin Releasing Hormone ◽  
Neurokinin B ◽  
Releasing Hormone ◽  
Estrogen Positive Feedback

Morphologic evidence that neurokinin B modulates gonadotropin-releasing hormone secretion via neurokinin 3 receptors in the rat median eminence

2005 ◽  
Vol 489 (3) ◽  
pp. 372-386 ◽  
Author(s):  
Sally J. Krajewski ◽  
Miranda J. Anderson ◽  
Lulu Iles-Shih ◽  
Kyung J. Chen ◽  
Henryk F. Urbanski ◽  
...  
Keyword(s):  
Median Eminence ◽  
Hormone Secretion ◽  
Gonadotropin Releasing Hormone ◽  
Neurokinin B ◽  
Releasing Hormone

scholarly journals Definition of Estrogen Receptor Pathway Critical for Estrogen Positive Feedback to Gonadotropin-Releasing Hormone Neurons and Fertility

Neuron ◽  
2006 ◽  
Vol 52 (2) ◽  
pp. 271-280 ◽  
Author(s):  
Tim M. Wintermantel ◽  
Rebecca E. Campbell ◽  
Robert Porteous ◽  
Dagmar Bock ◽  
Hermann-Josef Gröne ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Positive Feedback ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Estrogen Receptor Pathway ◽  
Definition Of ◽  
Estrogen Positive Feedback

scholarly journals Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Xinhuai Liu ◽  
Shel-Hwa Yeo ◽  
H James McQuillan ◽  
Michel K Herde ◽  
Sabine Hessler ◽  
...  
Keyword(s):  
Functional Significance ◽  
Hormone Secretion ◽  
Gonadotropin Releasing Hormone ◽  
Receptor Expression ◽  
Gnrh Neuron ◽  
Neurokinin B ◽  
Releasing Hormone ◽  
Pulsatile Hormone Secretion ◽  
Kndy Neurons

The necessity and functional significance of neurotransmitter co-transmission remains unclear. The glutamatergic ‘KNDy’ neurons co-express kisspeptin, neurokinin B (NKB), and dynorphin and exhibit a highly stereotyped synchronized behavior that reads out to the gonadotropin-releasing hormone (GnRH) neuron dendrons to drive episodic hormone secretion. Using expansion microscopy, we show that KNDy neurons make abundant close, non-synaptic appositions with the GnRH neuron dendron. Electrophysiology and confocal GCaMP6 imaging demonstrated that, despite all three neuropeptides being released from KNDy terminals, only kisspeptin was able to activate the GnRH neuron dendron. Mice with a selective deletion of kisspeptin from KNDy neurons failed to exhibit pulsatile hormone secretion but maintained synchronized episodic KNDy neuron behavior that is thought to depend on recurrent NKB and dynorphin transmission. This indicates that KNDy neurons drive episodic hormone secretion through highly redundant neuropeptide co-transmission orchestrated by differential post-synaptic neuropeptide receptor expression at the GnRH neuron dendron and KNDy neuron.

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