Morphologic evidence that neurokinin B modulates gonadotropin-releasing hormone secretion via neurokinin 3 receptors in the rat median eminence

2005 ◽  
Vol 489 (3) ◽  
pp. 372-386 ◽  
Author(s):  
Sally J. Krajewski ◽  
Miranda J. Anderson ◽  
Lulu Iles-Shih ◽  
Kyung J. Chen ◽  
Henryk F. Urbanski ◽  
...  
Keyword(s):  
Median Eminence ◽  
Hormone Secretion ◽  
Gonadotropin Releasing Hormone ◽  
Neurokinin B ◽  
Releasing Hormone

scholarly journals Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Xinhuai Liu ◽  
Shel-Hwa Yeo ◽  
H James McQuillan ◽  
Michel K Herde ◽  
Sabine Hessler ◽  
...  
Keyword(s):  
Functional Significance ◽  
Hormone Secretion ◽  
Gonadotropin Releasing Hormone ◽  
Receptor Expression ◽  
Gnrh Neuron ◽  
Neurokinin B ◽  
Releasing Hormone ◽  
Pulsatile Hormone Secretion ◽  
Kndy Neurons

The necessity and functional significance of neurotransmitter co-transmission remains unclear. The glutamatergic ‘KNDy’ neurons co-express kisspeptin, neurokinin B (NKB), and dynorphin and exhibit a highly stereotyped synchronized behavior that reads out to the gonadotropin-releasing hormone (GnRH) neuron dendrons to drive episodic hormone secretion. Using expansion microscopy, we show that KNDy neurons make abundant close, non-synaptic appositions with the GnRH neuron dendron. Electrophysiology and confocal GCaMP6 imaging demonstrated that, despite all three neuropeptides being released from KNDy terminals, only kisspeptin was able to activate the GnRH neuron dendron. Mice with a selective deletion of kisspeptin from KNDy neurons failed to exhibit pulsatile hormone secretion but maintained synchronized episodic KNDy neuron behavior that is thought to depend on recurrent NKB and dynorphin transmission. This indicates that KNDy neurons drive episodic hormone secretion through highly redundant neuropeptide co-transmission orchestrated by differential post-synaptic neuropeptide receptor expression at the GnRH neuron dendron and KNDy neuron.

scholarly journals Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse

2009 ◽  
Vol 29 (38) ◽  
pp. 11859-11866 ◽  
Author(s):  
V. M. Navarro ◽  
M. L. Gottsch ◽  
C. Chavkin ◽  
H. Okamura ◽  
D. K. Clifton ◽  
...  
Keyword(s):  
Arcuate Nucleus ◽  
Hormone Secretion ◽  
Gonadotropin Releasing Hormone ◽  
Neurokinin B ◽  
Releasing Hormone
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