scholarly journals Prodromal Symptom Severity Predicts Accelerated Gray Matter Reduction and Third Ventricle Expansion among Clinically High-Risk Youth Developing Psychotic Disorders

2015 ◽  
Vol 1 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Yoonho Chung ◽  
Aron Jacobson ◽  
George He ◽  
Theo G.M. van Erp ◽  
Sarah McEwen ◽  
...  
Keyword(s):  
High Risk ◽  
Gray Matter ◽  
Symptom Severity ◽  
Psychotic Disorders ◽  
Third Ventricle ◽  
Prodromal Symptom ◽  
High Risk Youth

scholarly journals Gray Matter Alterations in Schizophrenia High-Risk Youth and Early-Onset Schizophrenia

2013 ◽  
Vol 22 (4) ◽  
pp. 689-714 ◽  
Author(s):  
Benjamin K. Brent ◽  
Heidi W. Thermenos ◽  
Matcheri S. Keshavan ◽  
Larry J. Seidman
Keyword(s):  
High Risk ◽  
Gray Matter ◽  
Early Onset ◽  
Early Onset Schizophrenia ◽  
High Risk Youth

scholarly journals Functional development in clinical high risk youth: Prediction of schizophrenia versus other psychotic disorders

2014 ◽  
Vol 215 (1) ◽  
pp. 52-60 ◽  
Author(s):  
Sarah I. Tarbox ◽  
Jean Addington ◽  
Kristin S. Cadenhead ◽  
Tyrone D. Cannon ◽  
Barbara A. Cornblatt ◽  
...  
Keyword(s):  
High Risk ◽  
Psychotic Disorders ◽  
Clinical High Risk ◽  
Functional Development ◽  
High Risk Youth

High-Risk Youth Behaviors Decreasing Over Time

2008 ◽  
Vol 42 (7) ◽  
pp. 26-27
Author(s):  
MARY ELLEN SCHNEIDER
Keyword(s):  
High Risk ◽  
High Risk Youth ◽  
Over Time ◽  
Youth Behaviors

1363-P: Cyber School: A Marker of High-Risk Youth with Diabetes?

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1363-P
Author(s):  
CHRISTINE MARCH ◽  
LINDA M. SIMINERIO ◽  
ELIZABETH MILLER ◽  
INGRID LIBMAN
Keyword(s):  
High Risk ◽  
Cyber School ◽  
High Risk Youth

scholarly journals Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis

2021 ◽  
Author(s):  
Meike Heurich ◽  
Melanie Föcking ◽  
David Mongan ◽  
Gerard Cagney ◽  
David R. Cotter
Keyword(s):  
High Risk ◽  
Psychotic Disorder ◽  
Psychotic Disorders ◽  
Clinical Symptoms ◽  
First Episode Psychosis ◽  
Specific Protein ◽  
First Episode ◽  
Clinical High Risk ◽  
Blood Proteins ◽  
Episode Psychosis

AbstractEarly identification and treatment significantly improve clinical outcomes of psychotic disorders. Recent studies identified protein components of the complement and coagulation systems as key pathways implicated in psychosis. These specific protein alterations are integral to the inflammatory response and can begin years before the onset of clinical symptoms of psychotic disorder. Critically, they have recently been shown to predict the transition from clinical high risk to first-episode psychosis, enabling stratification of individuals who are most likely to transition to psychotic disorder from those who are not. This reinforces the concept that the psychosis spectrum is likely a central nervous system manifestation of systemic changes and highlights the need to investigate plasma proteins as diagnostic or prognostic biomarkers and pathophysiological mediators. In this review, we integrate evidence of alterations in proteins belonging to the complement and coagulation protein systems, including the coagulation, anticoagulation, and fibrinolytic pathways and their dysregulation in psychosis, into a consolidated mechanism that could be integral to the progression and manifestation of psychosis. We consolidate the findings of altered blood proteins relevant for progression to psychotic disorders, using data from longitudinal studies of the general population in addition to clinical high-risk (CHR) individuals transitioning to psychotic disorder. These are compared to markers identified from first-episode psychosis and schizophrenia as well as other psychosis spectrum disorders. We propose the novel hypothesis that altered complement and coagulation plasma levels enhance their pathways’ activating capacities, while low levels observed in key regulatory components contribute to excessive activation observed in patients. This hypothesis will require future testing through a range of experimental paradigms, and if upheld, complement and coagulation pathways or specific proteins could be useful diagnostic or prognostic tools and targets for early intervention and preventive strategies.

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