scholarly journals HLA-B Alleles B*15:01 and B*15:02: Opposite Association with Hepatitis C Virus Infection in Chinese Voluntary Blood Donors

Intervirology ◽  
2015 ◽  
Vol 58 (2) ◽  
pp. 80-87 ◽  
Author(s):  
Huaping Xiong ◽  
Jieting Huang ◽  
Xia Rong ◽  
Ming Zhang ◽  
Ke Huang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Donors ◽  
Human Leukocyte ◽  
Infected Group ◽  
Hcv Infection ◽  
Hepatitis C Virus Infection ◽  
Hla Alleles ◽  
Host Immune Responses ◽  
Leukocyte Antigens

Background: Although human leukocyte antigens (HLA) have been shown in association with the outcomes of hepatitis C virus (HCV) infection among different ethnic groups, such studies remain absent in China, where the HCV prevalence is higher than the global average. Methods: In this study, 426 HCV-infected and 709 uninfected blood donors were analyzed, among whom the HLA alleles were sequenced using a high-resolution genotyping method. Results: At the 2-digit level, none of the alleles showed a statistical difference between the HCV-infected and uninfected groups. However, at the 4-digit level, the HLA-B alleles B*15:01 and B*15:02 showed an opposite association with HCV infection, i.e. B*15:01 was significantly higher in the HCV-infected group (odds ratio, OR = 1.561, p = 0.010), while B*15:02 was significantly higher in the uninfected group (OR = 0.778, p = 0.016). We also identified a higher frequency of B*13:02 in the HCV-infected group (OR = 1.515, p = 0.009) and a higher frequency of B*07:05 in the uninfected group (OR = 0.299, p = 0.001). Conclusions: The frequencies of four HLA alleles, B*07:05, B*13:02, B*15:01, and B*15:02, were found to be significantly different between the HCV-infected and uninfected blood donors in China, revealing an inverse relation of B*15:01 and B*15:02 with HCV infection. This finding suggests that the ethnic genetic variations of HLA may greatly affect the host immune responses against HCV.

scholarly journals Synergism of tapasin and human leukocyte antigens in resolving hepatitis C virus infection

Hepatology ◽  
2013 ◽  
Vol 58 (3) ◽  
pp. 881-889 ◽  
Author(s):  
Shirin Ashraf ◽  
Katja Nitschke ◽  
Usama M. Warshow ◽  
Collin R. Brooks ◽  
Arthur Y. Kim ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Human Leukocyte ◽  
Human Leukocyte Antigens ◽  
Hepatitis C Virus Infection ◽  
Leukocyte Antigens

scholarly journals Impact of host responses on control of hepatitis C virus infection in Chinese blood donors

2011 ◽  
Vol 415 (3) ◽  
pp. 503-508 ◽  
Author(s):  
Tingting Li ◽  
Zixuan Chen ◽  
Jinfeng Zeng ◽  
Jingang Zhang ◽  
Wenjing Wang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Blood Donors ◽  
Host Responses ◽  
Hepatitis C Virus Infection

Diversity and origin of hepatitis C virus infection among unpaid blood donors in the Netherlands

Transfusion ◽  
2006 ◽  
Vol 46 (10) ◽  
pp. 1719-1728 ◽  
Author(s):  
Thijs J.W. Van De Laar ◽  
Marco H.G.M. Koppelman ◽  
Akke K. Van Der Bij ◽  
Hans L. Zaaijer ◽  
H. Theo M. Cuijpers ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
The Netherlands ◽  
Blood Donors ◽  
Hepatitis C Virus Infection

Prospective study of hepatitis C virus infection in hemodialysis patients by monthly analysis of HCV RNA and antibodies

2003 ◽  
Vol 49 (8) ◽  
pp. 503-507 ◽  
Author(s):  
Regina Moreira ◽  
João Renato Rebello Pinho ◽  
Jorge Fares ◽  
Isabel Takano Oba ◽  
Maria Regina Cardoso ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hemodialysis Patients ◽  
Hcv Infection ◽  
Hcv Rna ◽  
Hepatitis C Virus Infection ◽  
Serum Samples ◽  
Hcv Genotypes ◽  
High Prevalence ◽  
Time Required

The aims of this study were to (i) evaluate the prevalence and the incidence of hepatitis C virus (HCV) infection in hemodialysis patients in two different centers in São Paulo (Brazil), (ii) determine the time required to detect HCV infection among these patients by serology or PCR, (iii) establish the importance of alanine aminotransferase determination as a marker of HCV infection, and (iv) identify the HCV genotypes in this population. Serum samples were collected monthly for 1 year from 281 patients admitted to hospital for hemodialysis. Out of 281 patients, 41 patients (14.6%) were HCV positive; six patients seroconverted during this study (incidence = 3.1/1000 person-month). In 1.8% (5/281) of cases, RNA was detected before the appearance of antibodies (up to 5 months), and in 1.1% (3/281) of cases, RNA was the unique marker of HCV infection. The genotypes found were 1a, 1b, 3a, and 4a. The presence of genotype 4a is noteworthy, since it is a rare genotype in Brazil. These data pointed out the high prevalence and incidence of HCV infection at hemodialysis centers in Brazil and showed that routine PCR is fundamental for improving the detection of HCV carriers among patients undergoing hemodialysis.Key words: HCV genotypes, hemodialysis, hepatitis C, PCR, prevalence, incidence.

scholarly journals Screening for anti HCV

2016 ◽  
Vol 10 (2) ◽  
Author(s):  
Fatima Mehboob
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Observational Study ◽  
General Practitioners ◽  
Clinical Features ◽  
Screening Strategy ◽  
Medical Ward ◽  
Hcv Infection ◽  
Hepatitis C Virus Infection

Purpose of this study is to evaluate the different indications for screening for Anti HCV. This study was carried out in outdoor and indoor department of North Medical Ward of Mayo Hospital, Lahore. This is a non-interventional observational study. Two hundred patients ELISA proved HCV infection were evaluated to find out what were the different circumstances or symptomatology when tests for HCV infection were advised. So that a screening strategy can be formed. As hepatitis C virus infection has varied presentation and clinical features, the general practitioners, physicians, dermatologists and psychiatrists should be conscious about it an advise for Anti HCV detection whenever it is suspected. Screening of the early cases is beneficial both for the patients and its relatives.

Risk factors for hepatitis C virus infection among blood donors in northern Thailand

Transfusion ◽  
2004 ◽  
Vol 44 (10) ◽  
pp. 1433-1440 ◽  
Author(s):  
Lakkana Thaikruea ◽  
Satawat Thongsawat ◽  
Niwat Maneekarn ◽  
Dale Netski ◽  
David L. Thomas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Blood Donors ◽  
Hepatitis C Virus Infection ◽  
Northern Thailand

scholarly journals Risk factors for hepatitis C virus infection. A case-control study of blood donors in the Trent Region (UK)

1994 ◽  
Vol 112 (3) ◽  
pp. 595-601 ◽  
Author(s):  
K. R. Neal ◽  
D. A. Jones ◽  
D. Killey ◽  
V. James
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Transfusion ◽  
Blood Donors ◽  
Case Control Study ◽  
Case Control ◽  
Hcv Infection ◽  
History Of ◽  
Control Study

SUMMARYThe introduction of screening for hepatitis C virus (HCV) by the National Blood Transfusion Service identified donors who had acquired HCV infection. We undertook a case-control study amongst blood donors in the Trent Region to determine risks for HCV infection. A total of 74 blood donors confirmed positive for hepatitis C infection and 150 age, sex and donor venue matched controls were included in the study. Fifty-three percent of hepatitis C infected blood donors reported previous use of injected drugs compared to no controls; relative risk (RR) not estimatable (lower limit 95% CI = 20). Other risk factors were a history of: receipt of a blood transfusion or blood products RR = 3·6 (95% CI 1·5–8·3), having been a ‘health care worker’ RR = 2·8 (95% CI 1·1–7·6), tattooing RR = 3·3 (95% CI 1·2–8·7), and an association with having been born abroad RR = 3·2 (95% CI 1·1–9·5). No risk was shown for a history of multiple sexual partners, ear piercing or acupuncture. Injecting drug use explains more than 50% of hepatitis C infections in blood donors, a group who are less likely to have injected drugs than the general population.

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