scholarly journals Synergism of tapasin and human leukocyte antigens in resolving hepatitis C virus infection

Hepatology ◽  
2013 ◽  
Vol 58 (3) ◽  
pp. 881-889 ◽  
Author(s):  
Shirin Ashraf ◽  
Katja Nitschke ◽  
Usama M. Warshow ◽  
Collin R. Brooks ◽  
Arthur Y. Kim ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Human Leukocyte ◽  
Human Leukocyte Antigens ◽  
Hepatitis C Virus Infection ◽  
Leukocyte Antigens

scholarly journals Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope

Hepatology ◽  
2009 ◽  
Vol 51 (1) ◽  
pp. 54-62 ◽  
Author(s):  
Christoph Neumann-Haefelin ◽  
Jörg Timm ◽  
Julia Schmidt ◽  
Nadine Kersting ◽  
Karen Fitzmaurice ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Protective Effect ◽  
Cell Epitope ◽  
Human Leukocyte ◽  
Cd8 T Cell ◽  
T Cell Epitope ◽  
Hepatitis C Virus Infection ◽  
Leukocyte Antigen

scholarly journals HLA-B Alleles B*15:01 and B*15:02: Opposite Association with Hepatitis C Virus Infection in Chinese Voluntary Blood Donors

Intervirology ◽  
2015 ◽  
Vol 58 (2) ◽  
pp. 80-87 ◽  
Author(s):  
Huaping Xiong ◽  
Jieting Huang ◽  
Xia Rong ◽  
Ming Zhang ◽  
Ke Huang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Donors ◽  
Human Leukocyte ◽  
Infected Group ◽  
Hcv Infection ◽  
Hepatitis C Virus Infection ◽  
Hla Alleles ◽  
Host Immune Responses ◽  
Leukocyte Antigens

Background: Although human leukocyte antigens (HLA) have been shown in association with the outcomes of hepatitis C virus (HCV) infection among different ethnic groups, such studies remain absent in China, where the HCV prevalence is higher than the global average. Methods: In this study, 426 HCV-infected and 709 uninfected blood donors were analyzed, among whom the HLA alleles were sequenced using a high-resolution genotyping method. Results: At the 2-digit level, none of the alleles showed a statistical difference between the HCV-infected and uninfected groups. However, at the 4-digit level, the HLA-B alleles B*15:01 and B*15:02 showed an opposite association with HCV infection, i.e. B*15:01 was significantly higher in the HCV-infected group (odds ratio, OR = 1.561, p = 0.010), while B*15:02 was significantly higher in the uninfected group (OR = 0.778, p = 0.016). We also identified a higher frequency of B*13:02 in the HCV-infected group (OR = 1.515, p = 0.009) and a higher frequency of B*07:05 in the uninfected group (OR = 0.299, p = 0.001). Conclusions: The frequencies of four HLA alleles, B*07:05, B*13:02, B*15:01, and B*15:02, were found to be significantly different between the HCV-infected and uninfected blood donors in China, revealing an inverse relation of B*15:01 and B*15:02 with HCV infection. This finding suggests that the ethnic genetic variations of HLA may greatly affect the host immune responses against HCV.

Upregulation of soluble and membrane-bound human leukocyte antigen G expression is primarily observed in the milder histopathological stages of chronic hepatitis C virus infection

2012 ◽  
Vol 73 (3) ◽  
pp. 258-262 ◽  
Author(s):  
Janaina Cristiana de Oliveira Crispim ◽  
Tarsia Giabardo Alves Silva ◽  
Francisco José Dutra Souto ◽  
Fernanda Fernandes Souza ◽  
Carmen Lucia Bassi ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Human Leukocyte ◽  
Hepatitis C Virus Infection ◽  
Leukocyte Antigen ◽  
Chronic Hepatitis C Virus ◽  
Membrane Bound ◽  
Human Leukocyte Antigen G
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