Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery

2014 ◽  
pp. 106-115 ◽  
Author(s):  
Angelika Alonso
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

scholarly journals Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery

2016 ◽  
Vol 36 (29) ◽  
pp. 7727-7739 ◽  
Author(s):  
U. Vazana ◽  
R. Veksler ◽  
G. S. Pell ◽  
O. Prager ◽  
M. Fassler ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

Abstract 6251: Blood brain barrier opening by TTFields: a future CNS drug delivery strategy

2020 ◽  
Author(s):  
Ellaine Salvador ◽  
Almuth F. Kessler ◽  
Julia Hörmann ◽  
Malgorzata Burek ◽  
Catherine T. Brami ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Delivery Strategy ◽  
Cns Drug Delivery ◽  
Blood Brain ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

Optimization of osmotic blood-brain barrier opening to enable intravital microscopy studies on drug delivery in mouse cortex

2020 ◽  
Vol 317 ◽  
pp. 312-321 ◽  
Author(s):  
Chengyan Chu ◽  
Anna Jablonska ◽  
Wojciech G. Lesniak ◽  
Aline M. Thomas ◽  
Xiaoyan Lan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Intravital Microscopy ◽  
Brain Barrier ◽  
Blood Brain ◽  
Mouse Cortex ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

scholarly journals Focused ultrasound blood brain barrier opening mediated delivery of MRI-visible albumin nanoclusters to the rat brain for localized drug delivery with temporal control

2019 ◽  
Author(s):  
Megan C. Rich ◽  
Jennifer Sherwood ◽  
Aundrea F. Bartley ◽  
Quentin A. Whitsitt ◽  
W.R. Willoughby ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Rat Brain ◽  
Blood Brain Barrier ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Temporal Specificity ◽  
Blood Brain ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

AbstractThere is an ongoing need for noninvasive tools to manipulate brain activity with molecular, spatial and temporal specificity. Here we have investigated the use of MRI-visible, albumin-based nanoclusters for noninvasive, localized and temporally specific drug delivery to the rat brain. We demonstrated that IV injected nanoclusters could be deposited into target brain regions via focused ultrasound facilitated blood brain barrier opening. We showed that nanocluster location could be confirmed in vivo with MRI. Additionally, following confirmation of nanocluster delivery, release of the nanocluster payload into brain tissue can be triggered by a second focused ultrasound treatment performed without circulating microbubbles. Release of glutamate from nanoclusters in vivo caused enhanced c-Fos expression, indicating that the loading capacity of the nanoclusters is sufficient to induce neuronal activation. This novel technique for noninvasive stereotactic drug delivery to the brain with temporal specificity could provide a new way to study brain circuits in vivo preclinically with high relevance for clinical translation.Graphical Abstract

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