Targeted drug delivery with focus ultrasound-induced blood-brain barrier opening Using acoustically-activated nanodroplets

2013 ◽  
Author(s):  
Cherry C. Chen ◽  
Paul S. Sheeran ◽  
Shih-Ying Wu ◽  
Oluyemi Olumolade ◽  
Paul A. Dayton ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Targeted Drug Delivery ◽  
Focus Ultrasound ◽  
Brain Barrier ◽  
Blood Brain ◽  
Targeted Drug ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

scholarly journals Targeted drug delivery with focused ultrasound-induced blood-brain barrier opening using acoustically-activated nanodroplets

2013 ◽  
Vol 172 (3) ◽  
pp. 795-804 ◽  
Author(s):  
Cherry C. Chen ◽  
Paul S. Sheeran ◽  
Shih-Ying Wu ◽  
Oluyemi O. Olumolade ◽  
Paul A. Dayton ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Targeted Drug Delivery ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Blood Brain ◽  
Targeted Drug ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

scholarly journals Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery

2016 ◽  
Vol 36 (29) ◽  
pp. 7727-7739 ◽  
Author(s):  
U. Vazana ◽  
R. Veksler ◽  
G. S. Pell ◽  
O. Prager ◽  
M. Fassler ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

Recent Advances in Targeted Drug Delivery Approaches using Lipidic and Polymeric Nanocarriers for the management of Alzheimer’s Disease

2021 ◽  
Vol 27 ◽  
Author(s):  
Dhara Lakdawala ◽  
Md Abdur Rashid ◽  
Farhan Jalees Ahmad
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Blood Brain Barrier ◽  
Targeted Drug Delivery ◽  
Brain Barrier ◽  
Polymeric Nanocarriers ◽  
Blood Brain ◽  
Targeted Drug ◽  
The Brain

: Drug delivery to the brain has remained a significant challenge in treating neurodegenerative disorders such as Alzheimer's disease due to the presence of the blood-brain barrier, which primarily obstructs the access of drugs and biomolecules into the brain. Several methods to overcome the blood-brain barrier have been employed, such as chemical disruption, surgical intervention, focused ultrasound, intranasal delivery and using nanocarriers. Nanocarrier systems remain the method of choice and have shown promising results over the past decade to achieve better drug targeting. Polymeric nanocarriers and lipidic nanoparticles act as a carrier system providing better encapsulation of drugs, site-specific delivery, increased bioavailability and sustained release of drugs. The surface modifications and functionalization of these nanocarrier systems have greatly facilitated targeted drug delivery. The safety and efficacy of these nanocarrier systems have been ascertained by several in vitro and in vivo models. In the present review, we have elaborated on recent developments of nanoparticles as a drug delivery system for Alzheimer's disease, explicitly focusing on polymeric and lipidic nanoparticles.

Abstract 6251: Blood brain barrier opening by TTFields: a future CNS drug delivery strategy

2020 ◽  
Author(s):  
Ellaine Salvador ◽  
Almuth F. Kessler ◽  
Julia Hörmann ◽  
Malgorzata Burek ◽  
Catherine T. Brami ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Delivery Strategy ◽  
Cns Drug Delivery ◽  
Blood Brain ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

GDNF fusion protein for targeted-drug delivery across the human blood–brain barrier

2008 ◽  
Vol 100 (2) ◽  
pp. 387-396 ◽  
Author(s):  
Ruben J. Boado ◽  
Yun Zhang ◽  
Yufeng Zhang ◽  
Yuntao Wang ◽  
William M. Pardridge
Keyword(s):  
Drug Delivery ◽  
Fusion Protein ◽  
Blood Brain Barrier ◽  
Human Blood ◽  
Targeted Drug Delivery ◽  
Brain Barrier ◽  
Blood Brain ◽  
Targeted Drug

Optimization of osmotic blood-brain barrier opening to enable intravital microscopy studies on drug delivery in mouse cortex

2020 ◽  
Vol 317 ◽  
pp. 312-321 ◽  
Author(s):  
Chengyan Chu ◽  
Anna Jablonska ◽  
Wojciech G. Lesniak ◽  
Aline M. Thomas ◽  
Xiaoyan Lan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Intravital Microscopy ◽  
Brain Barrier ◽  
Blood Brain ◽  
Mouse Cortex ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening
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