Cerebrospinal Fluid Physiology and Its Role in Neurologic Disease

2015 ◽  
pp. 33-47
Author(s):  
William G. Bradley
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurologic Disease

LINEAR NEVUS SEBACEOUS SYNDROME: REPORT OF TWO CASES AND A REVIEW OF THE LITERATURE

PEDIATRICS ◽  
1973 ◽  
Vol 52 (3) ◽  
pp. 382-387
Author(s):  
Frederick H. Lovejoy ◽  
William E. Boyle
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurologic Disease ◽  
Review Of The Literature ◽  
Cutaneous Lesions ◽  
Neurocutaneous Syndromes ◽  
Nevus Sebaceous ◽  
Cerebrospinal Fluid Protein ◽  
Syndrome Report

Two cases of linear nevus sebaceous syndrome are described and a review of the eleven cases now reported in the literature is undertaken. The first patient has retardation, seizures, and classic ectodermal lesions while the second patient manifests typical cutaneous lesions and only an elevated cerebrospinal fluid protein as evidence of neurologic disease. The rationale for defining the syndrome as an entity distinct from other neurocutaneous syndromes is discussed and a pleomorphic presentation of the syndrome is suggested.

scholarly journals Cerebrospinal fluid mtDNA concentration is elevated in multiple sclerosis disease and responds to treatment

2017 ◽  
Vol 24 (4) ◽  
pp. 472-480 ◽  
Author(s):  
Cyra E Leurs ◽  
Petar Podlesniy ◽  
Ramon Trullas ◽  
Lisanne Balk ◽  
Martijn D Steenwijk ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Disease Progression ◽  
Progressive Multiple Sclerosis ◽  
Neurologic Disease ◽  
Brain Volumes ◽  
Multiple Sclerosis Disease ◽  
Relapsing Remitting ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Digital Polymerase Chain Reaction

Background: Mitochondrial dysfunction is increasingly recognized as an important feature of multiple sclerosis (MS) pathology and may be relevant for clinical disease progression. However, it is unknown whether mitochondrial DNA (mtDNA) levels in the cerebrospinal fluid (CSF) associate with disease progression and therapeutic response. Objectives: To evaluate whether CSF concentrations of mtDNA in MS patients can serve as a marker of ongoing neuropathology and may be helpful to differentiate between MS disease subtypes. To explore the effect of disease-modifying therapies on mtDNA levels in the CSF. Methods: CSF mtDNA was measured using a digital polymerase chain reaction (PCR) CSF mtDNA in two independent MS cohorts. The cohorts included 92 relapsing-remitting multiple sclerosis (RRMS) patients, 40 progressive multiple sclerosis (PMS) patients (27 secondary progressive and 13 primary progressive), 50 various neurologic disease controls, and 5 healthy controls. Results: Patients with PMS showed a significant increase in CSF mtDNA compared to non-inflammatory neurologic disease controls. Patients with higher T2 lesion volumes and lower normalized brain volumes showed increased concentration of mtDNA. Patients treated with fingolimod had significantly lower mtDNA copy levels at follow-up compared to baseline. Conclusion: Our results showed a non-specific elevation of concentration of mtDNA in PMS patients. mtDNA concentrations respond to fingolimod and may be used to monitor biological effect of this treatment.

Cerebrospinal fluid tau protein is not elevated in HIV-associated neurologic disease in humans

1998 ◽  
Vol 254 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Ronald J Ellis ◽  
Peter Seubert ◽  
Ruth Motter ◽  
Douglas Galasko ◽  
Reena Deutsch ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Tau Protein ◽  
Neurologic Disease

scholarly journals Presence of cerebrospinal fluid antibodies associated with autoimmune encephalitis of humans in dogs with neurologic disease

2019 ◽  
Vol 33 (5) ◽  
pp. 2175-2182
Author(s):  
Emma G. Stafford ◽  
Amanda Kortum ◽  
Aude Castel ◽  
Lauren Green ◽  
Jeanie Lau ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Autoimmune Encephalitis ◽  
Neurologic Disease

Hepatocyte growth factor in cerebrospinal fluid in neurologic disease

2002 ◽  
Vol 106 (2) ◽  
pp. 99-103 ◽  
Author(s):  
Y. Tsuboi ◽  
K. Kakimoto ◽  
H. Akatsu ◽  
Y. Daikuhara ◽  
T. Yamada
Keyword(s):  
Cerebrospinal Fluid ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Neurologic Disease ◽  
Hepatocyte Growth

Neurosymptomatic cerebrospinal fluid escape in HIV-2: a case report

2017 ◽  
Vol 29 (7) ◽  
pp. 726-728 ◽  
Author(s):  
Vinay Kulkarni ◽  
Rahul Kulkarni ◽  
Ritu Parchure
Keyword(s):  
Cerebrospinal Fluid ◽  
Case Report ◽  
Neurologic Disease ◽  
Escape Phenomenon ◽  
Hiv 1 ◽  
Csf Escape

Cerebrospinal fluid (CSF) escape phenomenon is widely studied and documented in HIV-1. However, hardly anything is known about progressive neurologic disease in otherwise well-controlled HIV-2 infection. We present a case of neurosymptomatic CSF escape in HIV-2 infection from India.

Cerebrospinal Fluid Glutamic Oxalacetic Transaminase Activity in Neurologic Disease

Neurology ◽  
1957 ◽  
Vol 7 (5) ◽  
pp. 313-313 ◽  
Author(s):  
J. B. Green ◽  
H. A. Oldewurtel ◽  
D. S. O'Doherty ◽  
F. M. Forster ◽  
L. P. Sanchez-Longo
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurologic Disease ◽  
Transaminase Activity ◽  
Glutamic Oxalacetic Transaminase
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