Comparison of creatine kinase in cerebrospinal fluid collected from the cerebellomedullary and lumbar cisterna in 10 dogs with neurologic disease

2020 ◽  
Vol 49 (3) ◽  
pp. 436-439
Author(s):  
Rachel Lampe ◽  
Kari D. Foss ◽  
Devon W. Hague ◽  
Anne M. Barger
Keyword(s):  
Cerebrospinal Fluid ◽  
Creatine Kinase ◽  
Neurologic Disease

Creatine kinase isoenzymes in cerebrospinal fluid in a case of brain damage.

1976 ◽  
Vol 22 (8) ◽  
pp. 1405-1407 ◽  
Author(s):  
P M Bayer ◽  
F Gabl ◽  
G Granditsch ◽  
K Widhalm ◽  
H Zyman ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Creatine Kinase ◽  
High Activity ◽  
Brain Damage ◽  
Acute Phase ◽  
Clinical Importance ◽  
Total Activity ◽  
Spinal Fluid ◽  
Consumption Coagulopathy ◽  
Creatine Kinase Isoenzymes

Abstract We present a case of a 11/2-year-old boy with toxic enteritis, consecutive consumption coagulopathy, and sever brain damage. During the acute phase we found high activity of the BB isoenzyme of creatine kinase in cerebrospinal fluid, but not in the serum. Isoenzyme MM could also be found in the spinal fluid (37.9% of the total activity). We conclude that analysis for creatine kinase isoenzymes in spinal fluid is of clinical importance.

LINEAR NEVUS SEBACEOUS SYNDROME: REPORT OF TWO CASES AND A REVIEW OF THE LITERATURE

PEDIATRICS ◽  
1973 ◽  
Vol 52 (3) ◽  
pp. 382-387
Author(s):  
Frederick H. Lovejoy ◽  
William E. Boyle
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurologic Disease ◽  
Review Of The Literature ◽  
Cutaneous Lesions ◽  
Neurocutaneous Syndromes ◽  
Nevus Sebaceous ◽  
Cerebrospinal Fluid Protein ◽  
Syndrome Report

Two cases of linear nevus sebaceous syndrome are described and a review of the eleven cases now reported in the literature is undertaken. The first patient has retardation, seizures, and classic ectodermal lesions while the second patient manifests typical cutaneous lesions and only an elevated cerebrospinal fluid protein as evidence of neurologic disease. The rationale for defining the syndrome as an entity distinct from other neurocutaneous syndromes is discussed and a pleomorphic presentation of the syndrome is suggested.

Cerebrospinal fluid creatine kinase BB isoenzyme activity and neurologic prognosis after cardiac arrest

Neurology ◽  
1997 ◽  
Vol 48 (2) ◽  
pp. 352-357 ◽  
Author(s):  
D. L. Tirschwell ◽  
W. T. Longstreth ◽  
M. E. Rauch-Matthews ◽  
W. L. Chandler ◽  
T. Rothstein ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Creatine Kinase ◽  
Cardiac Arrest ◽  
Creatine Kinase Bb

Creatine Kinase Isoenzyme DB in Cerebrospinal Fluid from Patients with Meningitis and Encephalitis

1983 ◽  
Vol 148 (1) ◽  
pp. 180-180 ◽  
Author(s):  
H. Briem ◽  
L. Lindquist ◽  
P. Lundbergh ◽  
E. Sego ◽  
B. Skoldenberg
Keyword(s):  
Cerebrospinal Fluid ◽  
Creatine Kinase ◽  
Creatine Kinase Isoenzyme

scholarly journals Cerebrospinal fluid mtDNA concentration is elevated in multiple sclerosis disease and responds to treatment

2017 ◽  
Vol 24 (4) ◽  
pp. 472-480 ◽  
Author(s):  
Cyra E Leurs ◽  
Petar Podlesniy ◽  
Ramon Trullas ◽  
Lisanne Balk ◽  
Martijn D Steenwijk ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Disease Progression ◽  
Progressive Multiple Sclerosis ◽  
Neurologic Disease ◽  
Brain Volumes ◽  
Multiple Sclerosis Disease ◽  
Relapsing Remitting ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Digital Polymerase Chain Reaction

Background: Mitochondrial dysfunction is increasingly recognized as an important feature of multiple sclerosis (MS) pathology and may be relevant for clinical disease progression. However, it is unknown whether mitochondrial DNA (mtDNA) levels in the cerebrospinal fluid (CSF) associate with disease progression and therapeutic response. Objectives: To evaluate whether CSF concentrations of mtDNA in MS patients can serve as a marker of ongoing neuropathology and may be helpful to differentiate between MS disease subtypes. To explore the effect of disease-modifying therapies on mtDNA levels in the CSF. Methods: CSF mtDNA was measured using a digital polymerase chain reaction (PCR) CSF mtDNA in two independent MS cohorts. The cohorts included 92 relapsing-remitting multiple sclerosis (RRMS) patients, 40 progressive multiple sclerosis (PMS) patients (27 secondary progressive and 13 primary progressive), 50 various neurologic disease controls, and 5 healthy controls. Results: Patients with PMS showed a significant increase in CSF mtDNA compared to non-inflammatory neurologic disease controls. Patients with higher T2 lesion volumes and lower normalized brain volumes showed increased concentration of mtDNA. Patients treated with fingolimod had significantly lower mtDNA copy levels at follow-up compared to baseline. Conclusion: Our results showed a non-specific elevation of concentration of mtDNA in PMS patients. mtDNA concentrations respond to fingolimod and may be used to monitor biological effect of this treatment.

Creatine Kinase Isoenzyme BB Concentrations in the Cerebrospinal Fluid of Newborns: Relationship to Short-term Outcome

PEDIATRICS ◽  
1991 ◽  
Vol 88 (6) ◽  
pp. 1204-1210
Author(s):  
Claudine De Praeter ◽  
Piet Vanhaesebrouck ◽  
Paul Govaert ◽  
Joris Delanghe ◽  
Jules Leroy
Keyword(s):  
Cerebrospinal Fluid ◽  
Creatine Kinase ◽  
Neonatal Period ◽  
Central Nervous System Infection ◽  
Short Term ◽  
Term Outcome ◽  
Neurologic Disorder ◽  
Short Term Outcome ◽  
High Concentrations ◽  
Immunoenzymatic Assay

Creatine kinase brain isoenzyme (CK-BB) was determined in cerebrospinal fluid of 150 neonates by a newly developed immunoenzymatic assay. Newborns with a documented neurologic disorder (intraventricular hemorrhage, postasphyxial encephalopathy, central nervous system infection, or persistent periventricular intraparenchymal echodensities) showed markedly higher concentrations of immunoreactive CK-BB than did the normal newborns or those with subarachnoid hemorrhage. In neonates with seizures the data suggest that the underlying neurologic disorder accounts for the higher CK-BB values and not the seizures per se. High concentrations of CK-BB in the neonatal period were followed by poor short-term outcome.

Cerebrospinal fluid tau protein is not elevated in HIV-associated neurologic disease in humans

1998 ◽  
Vol 254 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Ronald J Ellis ◽  
Peter Seubert ◽  
Ruth Motter ◽  
Douglas Galasko ◽  
Reena Deutsch ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Tau Protein ◽  
Neurologic Disease

Analysis of cardiac troponins and creatine kinase MB in cerebrospinal fluid in medicolegal autopsy cases

2009 ◽  
Vol 11 ◽  
pp. S266-S268 ◽  
Author(s):  
Hitoshi Maeda ◽  
Tomomi Michiue ◽  
Bao-Li Zhu ◽  
Takaki Ishikawa ◽  
Li Quan
Keyword(s):  
Cerebrospinal Fluid ◽  
Creatine Kinase ◽  
Creatine Kinase Mb ◽  
Medicolegal Autopsy ◽  
Cardiac Troponins
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