Relation of the rs6923761 Gene Variant in Glucagon-Like Peptide 1 Receptor to Metabolic Syndrome in Obese Subjects

2014 ◽  
Vol 65 (4) ◽  
pp. 253-258 ◽  
Author(s):  
Daniel Antonio de Luis ◽  
Rosario Bachiller ◽  
Olatz Izaola ◽  
Beatriz de la Fuente ◽  
Rocío Aller
Keyword(s):  
Metabolic Syndrome ◽  
Gene Variant ◽  
Obese Subjects ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Glucagon-like peptide-1 release and satiety after a nutrient challenge in normal-weight and obese subjects

2005 ◽  
Vol 93 (6) ◽  
pp. 845-851 ◽  
Author(s):  
Tanja C. M. Adam ◽  
Margriet S. Westerterp-Plantenga
Keyword(s):  
Fatty Acid ◽  
Guar Gum ◽  
Normal Weight ◽  
Satiety Hormone ◽  
Physiological Feedback ◽  
Obese Subjects ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Standard Breakfast ◽  
Analogue Scales

The present study was conducted to assess whether glucagon-like peptide-1 (GLP-1) release and appetite after a breakfast with or without an additional galactose/guar gum stimulation is different in normal-weight compared with overweight/obese subjects. Twenty-eight overweight/obese (BMI 30·3 (sd 2·7) kg/m2; age 44·3 (sd 9·7) years) and thirty normal-weight subjects (BMI 22·8 (sd 1·4), age 31·5 (sd12·8) years) participated in a crossover study. Fasting and postprandial plasma GLP-1, insulin, glucose and free fatty acid concentrations were measured in response to either a galactose (50 g)/guar gum (2·5 g) load (836 kJ) and a standard breakfast (1·9 MJ; GG), or water (250 ml) and the standard breakfast (W) every 30 min relative to the ingestion for 120 min. Appetite was assessed using 100 mm visual analogue scales. GLP-1 concentrations were significantly increased after GG at 30 and 60 min compared with W in both groups. Plasma GLP-1 concentrations in the W condition were higher in normal-weight than overweight/obese subjects (P=0·03). No difference was observed in the GG condition between groups. Satiety was increased in normal-weight compared with overweight/obese subjects in the GG condition at 30 (P=0·02) and 60 (P=0·04) min. We conclude that after a standard breakfast with water, GLP-1 release was lower in the overweight/obese than the normal-weight subjects. However, postprandial GLP-1 release in overweight/obese subjects was no different from that of normal-weight subjects when galactose/guar gum was added to the breakfast. The latter was not mirrored by subjective feelings of satiety. Disturbed perception of the physiological feedback of a satiety hormone rather than disturbed feedback itself might contribute to obesity.

Effect of meal composition on postprandial glucagon-like peptide-1, insulin, glucagon, C-peptide, and glucose responses in overweight/obese subjects

2016 ◽  
Vol 56 (3) ◽  
pp. 1053-1062 ◽  
Author(s):  
Meena Shah ◽  
Brian Franklin ◽  
Beverley Adams-Huet ◽  
Joel Mitchell ◽  
Brooke Bouza ◽  
...  
Keyword(s):  
C Peptide ◽  
Obese Subjects ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Meal Composition
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