Evaluation of Weight Loss and Adipocytokine Levels after Two Hypocaloric Diets with Different Macronutrient Distribution in Obese Subjects with the rs6923761 Gene Variant of Glucagon-Like Peptide 1 Receptor

2013 ◽  
Vol 63 (4) ◽  
pp. 277-282 ◽  
Author(s):  
Daniel Antonio de Luis ◽  
Rocío Aller ◽  
Olatz Izaola ◽  
Beatriz de la Fuente ◽  
David Primo ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gene Variant ◽  
Obese Subjects ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Macronutrient Distribution

Relation of the rs6923761 Gene Variant in Glucagon-Like Peptide 1 Receptor to Metabolic Syndrome in Obese Subjects

2014 ◽  
Vol 65 (4) ◽  
pp. 253-258 ◽  
Author(s):  
Daniel Antonio de Luis ◽  
Rosario Bachiller ◽  
Olatz Izaola ◽  
Beatriz de la Fuente ◽  
Rocío Aller
Keyword(s):  
Metabolic Syndrome ◽  
Gene Variant ◽  
Obese Subjects ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Nutrient-stimulated glucagon-like peptide 1 release after body-weight loss and weight maintenance in human subjects

2006 ◽  
Vol 95 (1) ◽  
pp. 160-167 ◽  
Author(s):  
Tanja C. M Adam ◽  
Manuela P. G. M. Lejeune ◽  
Margriet S. Westerterp-Plantenga
Keyword(s):  
Weight Loss ◽  
Human Subjects ◽  
Weight Maintenance ◽  
Body Weight Loss ◽  
Maintenance Period ◽  
Very Low Energy Diet ◽  
Obese Subjects ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Standard Breakfast

Glucagon-like peptide 1 (GLP-1) is a peptide hormone that is released in response to nutrient ingestion. Postprandial GLP-1 release has been reported to be attenuated in obese subjects, but reports on the effect of weight loss on GLP-1 are conflicting. The aim of the present study was to clarify the effect of a weight-loss period and a consecutive weight-maintenance period on nutrient-stimulated GLP-1 release in obese subjects. Nutrient-stimulated (standard breakfast; 1·9MJ) GLP-1 release was investigated in thirty-two obese subjects on three occasions: before weight loss (T1) (BMI 30·0 (sd 2·5) kg/m2); after a 6-week very-low-energy diet (VLED) (T2) (BMI 27·6 (sd 2·3) kg/m2); after a 3-month weight-maintenance period (T3) (BMI 27·9 (sd 2·3) kg/m2). At each occasion, following a fasting blood sample the test meal was fed and blood was drawn every 30min for 2h relative to ingestion in order to determine plasma GLP-1, insulin, glucose and NEFA concentrations. Subjects lost 7 (sd 3·4) kg during the VLED (P<0·0001) and regained 1 (sd 3·2) kg during the weight-maintenance period (NS). The area under the curve for nutrient-stimulated plasma GLP-1 (pmol/l×h) was significantly decreased (P=0·01) at T2 (6·8 (sd 1)) compared with T1 (12·8 (sd 2·9)) and T3 (11·1 (sd 1·5)). Since we found a rebound of concentrations after a weight-maintenance period, decrease after weight loss seems to be transient and possibly due to a negative energy balance.

Decreased Basal Levels of Glucagon-Like Peptide-1 after Weight Loss in Obese Subjects

2007 ◽  
Vol 51 (2) ◽  
pp. 134-138 ◽  
Author(s):  
D.A. de Luis ◽  
M. Gonzalez Sagrado ◽  
R. Conde ◽  
R. Aller ◽  
O. Izaola
Keyword(s):  
Weight Loss ◽  
Obese Subjects ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Evaluation of weight loss and adipocytokines levels after two hypocaloric diets with different macronutrient distribution in obese subjects with rs9939609 gene variant

2012 ◽  
Vol 28 (8) ◽  
pp. 663-668 ◽  
Author(s):  
Daniel Antonio de Luis ◽  
Rocío Aller ◽  
Olatz Izaola ◽  
Beatriz de la Fuente ◽  
Rosa Conde ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gene Variant ◽  
Obese Subjects ◽  
Macronutrient Distribution

scholarly journals Decreased Glucagon-like Peptide 1 Release after Weight Loss in Overweight/Obese Subjects

2005 ◽  
Vol 13 (4) ◽  
pp. 710-716 ◽  
Author(s):  
Tanja C. M. Adam ◽  
Johan Jocken ◽  
Margriet S. Westerterp-Plantenga
Keyword(s):  
Weight Loss ◽  
Obese Subjects ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Is it Time to Expand Glucagon-like Peptide-1 Receptor Agonist Use for Weight Loss in Patients Without Diabetes?

Drugs ◽  
2021 ◽  
Author(s):  
Wendy H. Updike ◽  
Olivia Pane ◽  
Rachel Franks ◽  
Faizah Saber ◽  
Farah Abdeen ◽  
...  
Keyword(s):  
Weight Loss ◽  
Receptor Agonist ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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