scholarly journals BDNF Modulates Contextual Fear Learning during Adolescence

2014 ◽  
Vol 36 (3-4) ◽  
pp. 269-276 ◽  
Author(s):  
Iva Dincheva ◽  
Siobhan S. Pattwell ◽  
Lino Tessarollo ◽  
Kevin G. Bath ◽  
Francis S. Lee
Keyword(s):  
Fear Learning ◽  
Contextual Fear

scholarly journals Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Matthew R. Baker ◽  
Ryan Y. Wong
Keyword(s):  
Neural Plasticity ◽  
Coping Style ◽  
Molecular Mechanisms ◽  
Conditioned Fear ◽  
Coping Styles ◽  
Brain Regions ◽  
Contextual Fear Conditioning ◽  
Fear Learning ◽  
Stress Coping ◽  
Contextual Fear

AbstractLearning to anticipate potentially dangerous contexts is an adaptive behavioral response to coping with stressors. An animal’s stress coping style (e.g. proactive–reactive axis) is known to influence how it encodes salient events. However, the neural and molecular mechanisms underlying these stress coping style differences in learning are unknown. Further, while a number of neuroplasticity-related genes have been associated with alternative stress coping styles, it is unclear if these genes may bias the development of conditioned behavioral responses to stressful stimuli, and if so, which brain regions are involved. Here, we trained adult zebrafish to associate a naturally aversive olfactory cue with a given context. Next, we investigated if expression of two neural plasticity and neurotransmission-related genes (npas4a and gabbr1a) were associated with the contextual fear conditioning differences between proactive and reactive stress coping styles. Reactive zebrafish developed a stronger conditioned fear response and showed significantly higher npas4a expression in the medial and lateral zones of the dorsal telencephalon (Dm, Dl), and the supracommissural nucleus of the ventral telencephalon (Vs). Our findings suggest that the expression of activity-dependent genes like npas4a may be differentially expressed across several interconnected forebrain regions in response to fearful stimuli and promote biases in fear learning among different stress coping styles.

The Future of Contextual Fear Learning for PTSD Research: A Methodological Review of Neuroimaging Studies

2017 ◽  
pp. 207-228 ◽  
Author(s):  
Daniel E. Glenn ◽  
Victoria B. Risbrough ◽  
Alan N. Simmons ◽  
Dean T. Acheson ◽  
Daniel M. Stout
Keyword(s):  
Fear Learning ◽  
Methodological Review ◽  
Contextual Fear ◽  
The Future

scholarly journals Isolation rearing-induced deficits in contextual fear learning do not require CRF2 receptors

2010 ◽  
Vol 209 (1) ◽  
pp. 80-84 ◽  
Author(s):  
Jodi E. Gresack ◽  
Victoria B. Risbrough ◽  
Christine N. Scott ◽  
Sarah Coste ◽  
Mary Stenzel-Poore ◽  
...  
Keyword(s):  
Fear Learning ◽  
Isolation Rearing ◽  
Contextual Fear

scholarly journals Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning

2014 ◽  
Vol 66 (2) ◽  
pp. 430-438 ◽  
Author(s):  
Prashant Mandela ◽  
Yan Yan ◽  
Taylor LaRese ◽  
Betty A. Eipper ◽  
Richard E. Mains
Keyword(s):  
Fear Learning ◽  
Contextual Fear

Loss of Hippocampal Oligodendrocytes Contributes to the Deficit of Contextual Fear Learning in Adult Rats Experiencing Early Bisphenol A Exposure

2016 ◽  
Vol 54 (6) ◽  
pp. 4524-4536 ◽  
Author(s):  
Xiao-Bin Xu ◽  
Shi-Jun Fan ◽  
Ye He ◽  
Xin Ke ◽  
Chen Song ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Fear Learning ◽  
Adult Rats ◽  
Contextual Fear

scholarly journals Differential behavioral, stress, and sleep responses in mice with different delays of fear extinction

SLEEP ◽  
2019 ◽  
Vol 42 (10) ◽  
Author(s):  
Mayumi Machida ◽  
Amy M Sutton ◽  
Brook L Williams ◽  
Laurie L Wellman ◽  
Larry D Sanford
Keyword(s):  
Body Temperature ◽  
Stress Responses ◽  
Dark Period ◽  
Contextual Fear Conditioning ◽  
Fear Learning ◽  
Contextual Fear ◽  
Behavioral Stress ◽  
And Behavior ◽  
Sleep Amount ◽  
Shock Training

Abstract Study Objectives Sleep, in particular rapid eye movement (REM), has been linked to fear learning and extinction; however, their relationship is poorly understood. We determined how different delays of extinction training (ET) impact fear-conditioned behaviors, changes in sleep, and stress responses. Methods EEG activity, movement, and body temperature in mice were monitored via telemetry. Following contextual fear conditioning (shock training [ST]), separate groups of mice were reexposed to the context at 24-hour post-ST (24h ET-1) and at 48-hour post-ST (48h ET-1). Post-ET sleep amount and sleep-associated EEG (delta and theta) activity were compared to baseline and to post-ST sleep. Freezing, locomotion, grooming, and rearing were monitored to determine effects of ET on fear behaviors. Body temperature immediately after ET was monitored to assess stress-induced hyperthermia (SIH). Results 24h ET-1 and 48h ET-1 produced similar freezing and REM reductions, but dissimilar rearing activity and SIH. 24h ET-1 was followed by periods of suppressed REM-associated theta (REM-θ) activity, immediately after ET and during the subsequent dark period. Suppressed REM-θ was specific to sleep after 24h ET-1, and did not occur after ST, nor after 48h ET-1. Conclusions ET-1 at 24 and 48 hours after ST was associated with similar freezing and REM amounts, but with differences in other overt behaviors, in REM-θ, and in SIH. Freezing was not predictive of changes in other fear-associated responses. This study demonstrated that consideration of time delay from fear acquisition to extinction is important when assessing the relationships between extinction and behavior, sleep, and stress responses.

scholarly journals Network supporting contextual fear learning after dorsal hippocampal damage has increased dependence on retrosplenial cortex

2018 ◽  
Vol 14 (8) ◽  
pp. e1006207 ◽  
Author(s):  
Cesar A. O. Coelho ◽  
Tatiana L. Ferreira ◽  
Juliana C. Kramer-Soares ◽  
João R. Sato ◽  
Maria Gabriela M. Oliveira
Keyword(s):  
Retrosplenial Cortex ◽  
Fear Learning ◽  
Hippocampal Damage ◽  
Contextual Fear ◽  
Dorsal Hippocampal
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