scholarly journals BDNF Modulates Contextual Fear Learning during Adolescence

2014 ◽  
Vol 36 (3-4) ◽  
pp. 269-276 ◽  
Author(s):  
Iva Dincheva ◽  
Siobhan S. Pattwell ◽  
Lino Tessarollo ◽  
Kevin G. Bath ◽  
Francis S. Lee
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Matthew R. Baker ◽  
Ryan Y. Wong

AbstractLearning to anticipate potentially dangerous contexts is an adaptive behavioral response to coping with stressors. An animal’s stress coping style (e.g. proactive–reactive axis) is known to influence how it encodes salient events. However, the neural and molecular mechanisms underlying these stress coping style differences in learning are unknown. Further, while a number of neuroplasticity-related genes have been associated with alternative stress coping styles, it is unclear if these genes may bias the development of conditioned behavioral responses to stressful stimuli, and if so, which brain regions are involved. Here, we trained adult zebrafish to associate a naturally aversive olfactory cue with a given context. Next, we investigated if expression of two neural plasticity and neurotransmission-related genes (npas4a and gabbr1a) were associated with the contextual fear conditioning differences between proactive and reactive stress coping styles. Reactive zebrafish developed a stronger conditioned fear response and showed significantly higher npas4a expression in the medial and lateral zones of the dorsal telencephalon (Dm, Dl), and the supracommissural nucleus of the ventral telencephalon (Vs). Our findings suggest that the expression of activity-dependent genes like npas4a may be differentially expressed across several interconnected forebrain regions in response to fearful stimuli and promote biases in fear learning among different stress coping styles.


Author(s):  
Daniel E. Glenn ◽  
Victoria B. Risbrough ◽  
Alan N. Simmons ◽  
Dean T. Acheson ◽  
Daniel M. Stout

2010 ◽  
Vol 209 (1) ◽  
pp. 80-84 ◽  
Author(s):  
Jodi E. Gresack ◽  
Victoria B. Risbrough ◽  
Christine N. Scott ◽  
Sarah Coste ◽  
Mary Stenzel-Poore ◽  
...  

2014 ◽  
Vol 66 (2) ◽  
pp. 430-438 ◽  
Author(s):  
Prashant Mandela ◽  
Yan Yan ◽  
Taylor LaRese ◽  
Betty A. Eipper ◽  
Richard E. Mains

2016 ◽  
Vol 54 (6) ◽  
pp. 4524-4536 ◽  
Author(s):  
Xiao-Bin Xu ◽  
Shi-Jun Fan ◽  
Ye He ◽  
Xin Ke ◽  
Chen Song ◽  
...  

SLEEP ◽  
2019 ◽  
Vol 42 (10) ◽  
Author(s):  
Mayumi Machida ◽  
Amy M Sutton ◽  
Brook L Williams ◽  
Laurie L Wellman ◽  
Larry D Sanford

Abstract Study Objectives Sleep, in particular rapid eye movement (REM), has been linked to fear learning and extinction; however, their relationship is poorly understood. We determined how different delays of extinction training (ET) impact fear-conditioned behaviors, changes in sleep, and stress responses. Methods EEG activity, movement, and body temperature in mice were monitored via telemetry. Following contextual fear conditioning (shock training [ST]), separate groups of mice were reexposed to the context at 24-hour post-ST (24h ET-1) and at 48-hour post-ST (48h ET-1). Post-ET sleep amount and sleep-associated EEG (delta and theta) activity were compared to baseline and to post-ST sleep. Freezing, locomotion, grooming, and rearing were monitored to determine effects of ET on fear behaviors. Body temperature immediately after ET was monitored to assess stress-induced hyperthermia (SIH). Results 24h ET-1 and 48h ET-1 produced similar freezing and REM reductions, but dissimilar rearing activity and SIH. 24h ET-1 was followed by periods of suppressed REM-associated theta (REM-θ) activity, immediately after ET and during the subsequent dark period. Suppressed REM-θ was specific to sleep after 24h ET-1, and did not occur after ST, nor after 48h ET-1. Conclusions ET-1 at 24 and 48 hours after ST was associated with similar freezing and REM amounts, but with differences in other overt behaviors, in REM-θ, and in SIH. Freezing was not predictive of changes in other fear-associated responses. This study demonstrated that consideration of time delay from fear acquisition to extinction is important when assessing the relationships between extinction and behavior, sleep, and stress responses.


2018 ◽  
Vol 14 (8) ◽  
pp. e1006207 ◽  
Author(s):  
Cesar A. O. Coelho ◽  
Tatiana L. Ferreira ◽  
Juliana C. Kramer-Soares ◽  
João R. Sato ◽  
Maria Gabriela M. Oliveira

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