scholarly journals Mast Cell-Deficient KitW-shMice Develop House Dust Mite-Induced Lung Inflammation despite Impaired Eosinophil Recruitment

2014 ◽  
Vol 6 (2) ◽  
pp. 219-226 ◽  
Author(s):  
J. Daan de Boer ◽  
Jack Yang ◽  
Florry E. van den Boogaard ◽  
Arie J. Hoogendijk ◽  
Regina de Beer ◽  
...  
Keyword(s):  
Mast Cell ◽  
House Dust ◽  
House Dust Mite ◽  
Lung Inflammation ◽  
Eosinophil Recruitment ◽  
Dust Mite

scholarly journals Mast cell‐derived serotonin enhances methacholine‐induced airway hyperresponsiveness in house dust mite‐induced experimental asthma

Allergy ◽  
2021 ◽  
Author(s):  
Erika Mendez‐Enriquez ◽  
Perla Abigail Alvarado‐Vazquez ◽  
Willem Abma ◽  
Oscar E. Simonson ◽  
Sergey Rodin ◽  
...  
Keyword(s):  
Mast Cell ◽  
House Dust ◽  
House Dust Mite ◽  
Airway Hyperresponsiveness ◽  
Dust Mite

House dust mite regulate the lung inflammation of asthmatic mice through TLR4 pathway in airway epithelial cells

2010 ◽  
Vol 28 (7) ◽  
pp. 597-603 ◽  
Author(s):  
Li Hongjia ◽  
Gai Qingling ◽  
Lin Meiying ◽  
Wang Weixuan ◽  
Zhang Lihong ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
House Dust ◽  
House Dust Mite ◽  
Lung Inflammation ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Dust Mite

Mast cell-derived serotonin enhances methacholine-induced airway hyperresponsiveness in house dust mite-induced experimental asthma

2021 ◽  
Author(s):  
Erika Haide Mendez ◽  
Perla Abigail Alvarado Vazquez ◽  
Willem Abma ◽  
Oscar Simonson ◽  
Sergey Rodin ◽  
...  
Keyword(s):  
Mast Cell ◽  
House Dust ◽  
House Dust Mite ◽  
Airway Hyperresponsiveness ◽  
Dust Mite

Effect of the oral thrombin inhibitor dabigatran on allergic lung inflammation induced by repeated house dust mite administration in mice

2015 ◽  
Vol 309 (8) ◽  
pp. L768-L775 ◽  
Author(s):  
Johannes D. de Boer ◽  
Lea C. Berkhout ◽  
Sacha F. de Stoppelaar ◽  
Jack Yang ◽  
Roelof Ottenhoff ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Lung Inflammation ◽  
Exposure Model ◽  
Thrombin Inhibitor ◽  
Lung Pathology ◽  
Coagulation Activation ◽  
Allergic Lung Inflammation ◽  
Dust Mite ◽  
Asthma Patients

Asthma is a chronic disease of the airways; asthma patients are hampered by recurrent symptoms of dyspnoea and wheezing caused by bronchial obstruction. Most asthma patients suffer from chronic allergic lung inflammation triggered by allergens such as house dust mite (HDM). Coagulation activation in the pulmonary compartment is currently recognized as a feature of allergic lung inflammation, and data suggest that coagulation proteases further drive inflammatory mechanisms. Here, we tested whether treatment with the oral thrombin inhibitor dabigatran attenuates allergic lung inflammation in a recently developed HDM-based murine asthma model. Mice were fed dabigatran (10 mg/g) or placebo chow during a 3-wk HDM airway exposure model. Dabigatran treatment caused systemic thrombin inhibitory activity corresponding with dabigatran levels reported in human trials. Surprisingly, dabigatran did not lead to inhibition of HDM-evoked coagulation activation in the lung as measured by levels of thrombin-antithrombin complexes and D-dimer. Repeated HDM administration caused an influx of eosinophils and neutrophils into the lungs, mucus production in the airways, and a T helper 2 response, as reflected by a rise in bronchoalveolar IL-4 and IL-5 levels and a systemic rise in IgE and HDM-IgG1. Dabigatran modestly improved HDM-induced lung pathology ( P < 0.05) and decreased IL-4 levels ( P < 0.01), without influencing other HDM-induced responses. Considering the limited effects of dabigatran in spite of adequate plasma levels, these results argue against clinical evaluation of dabigatran in patients with asthma.

scholarly journals House Dust Mite Induced Lung Inflammation Does Not Alter Circulating Vitamin D Levels

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112589 ◽  
Author(s):  
Ling Chen ◽  
Kara L. Perks ◽  
Stephen M. Stick ◽  
Anthony Kicic ◽  
Alexander N. Larcombe ◽  
...  
Keyword(s):  
Vitamin D ◽  
House Dust ◽  
House Dust Mite ◽  
Lung Inflammation ◽  
Vitamin D Levels ◽  
Dust Mite

scholarly journals The Allergen Der p3 from House Dust Mite Stimulates Store-Operated Ca2+ Channels and Mast Cell Migration through PAR4 Receptors

2018 ◽  
Vol 70 (2) ◽  
pp. 228-241.e5 ◽  
Author(s):  
Yu-Ping Lin ◽  
Charmaine Nelson ◽  
Holger Kramer ◽  
Anant B. Parekh
Keyword(s):  
Mast Cell ◽  
Cell Migration ◽  
House Dust ◽  
House Dust Mite ◽  
Dust Mite ◽  
Ca2 Channels

OX40 blockade inhibits house dust mite driven allergic lung inflammation in mice and in vitro allergic responses in humans

2015 ◽  
Vol 45 (4) ◽  
pp. 1116-1128 ◽  
Author(s):  
Katie E. Burrows ◽  
Celine Dumont ◽  
Clare L. Thompson ◽  
Matthew C. Catley ◽  
Kate L. Dixon ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Lung Inflammation ◽  
Allergic Lung Inflammation ◽  
Dust Mite
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