Lactococcus lactisKR-050L extract suppresses house dust mite induced-atopic skin inflammation through inhibition of keratinocyte and mast cell activation

2018 ◽  
Vol 126 (1) ◽  
pp. 230-241 ◽  
Author(s):  
M. Jin ◽  
S. Lee ◽  
Y.-A. Choi ◽  
H.-J. Jang ◽  
S.W. Lee ◽  
...  
Keyword(s):  
Mast Cell ◽  
House Dust ◽  
House Dust Mite ◽  
Cell Activation ◽  
Skin Inflammation ◽  
Mast Cell Activation ◽  
Dust Mite ◽  
Atopic Skin

scholarly journals Mast cell‐derived serotonin enhances methacholine‐induced airway hyperresponsiveness in house dust mite‐induced experimental asthma

Allergy ◽  
2021 ◽  
Author(s):  
Erika Mendez‐Enriquez ◽  
Perla Abigail Alvarado‐Vazquez ◽  
Willem Abma ◽  
Oscar E. Simonson ◽  
Sergey Rodin ◽  
...  
Keyword(s):  
Mast Cell ◽  
House Dust ◽  
House Dust Mite ◽  
Airway Hyperresponsiveness ◽  
Dust Mite

Mast cell-derived serotonin enhances methacholine-induced airway hyperresponsiveness in house dust mite-induced experimental asthma

2021 ◽  
Author(s):  
Erika Haide Mendez ◽  
Perla Abigail Alvarado Vazquez ◽  
Willem Abma ◽  
Oscar Simonson ◽  
Sergey Rodin ◽  
...  
Keyword(s):  
Mast Cell ◽  
House Dust ◽  
House Dust Mite ◽  
Airway Hyperresponsiveness ◽  
Dust Mite

scholarly journals Mast Cell-Deficient KitW-shMice Develop House Dust Mite-Induced Lung Inflammation despite Impaired Eosinophil Recruitment

2014 ◽  
Vol 6 (2) ◽  
pp. 219-226 ◽  
Author(s):  
J. Daan de Boer ◽  
Jack Yang ◽  
Florry E. van den Boogaard ◽  
Arie J. Hoogendijk ◽  
Regina de Beer ◽  
...  
Keyword(s):  
Mast Cell ◽  
House Dust ◽  
House Dust Mite ◽  
Lung Inflammation ◽  
Eosinophil Recruitment ◽  
Dust Mite

TRPV4 is a key driver for mast cell activation in LL37mediated skin inflammation

2017 ◽  
Vol 86 (2) ◽  
pp. e69
Author(s):  
Anna Di_Nardo ◽  
Nicholas Mascarenhas ◽  
Zhenping Wang
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Skin Inflammation ◽  
Mast Cell Activation ◽  
Key Driver

scholarly journals Effects of the Fruit Extract of Tribulus terrestris on Skin Inflammation in Mice with Oxazolone-Induced Atopic Dermatitis through Regulation of Calcium Channels, Orai-1 and TRPV3, and Mast Cell Activation

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Seok Yong Kang ◽  
Hyo Won Jung ◽  
Joo Hyun Nam ◽  
Woo Kyung Kim ◽  
Jong-Seong Kang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mast Cell ◽  
Calcium Channels ◽  
Cell Activation ◽  
Inflammatory Cells ◽  
Skin Inflammation ◽  
Mast Cell Activation ◽  
Tribulus Terrestris ◽  
Symptom Scores ◽  
Safe Approach

Ethnopharmacological Relevance. In this study, we investigated the effects of Tribulus terrestris fruit (Leguminosae, Tribuli Fructus, TF) extract on oxazolone-induced atopic dermatitis in mice. Materials and Methods. TF extract was prepared with 30% ethanol as solvent. The 1% TF extract with or without 0.1% HC was applied to the back skin daily for 24 days. Results. 1% TF extract with 0.1% HC improved AD symptoms and reduced TEWL and symptom scores in AD mice. 1% TF extract with 0.1% HC inhibited skin inflammation through decrease in inflammatory cells infiltration as well as inhibition of Orai-1 expression in skin tissues. TF extract inhibited Orai-1 activity in Orai-1-STIM1 cooverexpressing HEK293T cells but increased TRPV3 activity in TRPV3-overexpressing HEK293T cells. TF extract decreased β-hexosaminidase release in RBL-2H3 cells. Conclusions. The present study demonstrates that the topical application of TF extract improves skin inflammation in AD mice, and the mechanism for this effect appears to be related to the modulation of calcium channels and mast cell activation. This outcome suggests that the combination of TF and steroids could be a more effective and safe approach for AD treatment.

scholarly journals Enhanced Cysteinyl-Leukotriene Type 1 Receptor Expression in T Cells from House Dust Mite-Allergic Individuals following Stimulation with Der p

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Maryse Thivierge ◽  
Sylvie Turcotte ◽  
Marek Rola-Pleszczynski ◽  
Jana Stankova
Keyword(s):  
T Cells ◽  
T Cell ◽  
House Dust ◽  
House Dust Mite ◽  
Cell Activation ◽  
Mononuclear Cells ◽  
Receptor Expression ◽  
Peripheral Blood Mononuclear ◽  
Dust Mite ◽  
Cell Expression

In order to determine the potential for allergen to modulate T cell expression of the CysLT1receptor and responsiveness to leukotrienes, peripheral blood mononuclear cells from house dust mite-allergic or nonallergic individuals were incubated withD. pteronyssinusallergen (Der p). Baseline CysLT1expression was similar in both groups of donors, but Der p significantly enhanced CysLT1expression in CD4+and CD8+T cells of only allergic individuals and induced enhanced responsiveness of CD4+T cells to LTD4in terms of calcium mobilisation. This effect was prevented by the CysLT1antagonist MK571. Der p also induced IL-4 and IL-10 production, and neutralizing antibody to IL-4 prevented both the enhanced CysLT1expression and the enhanced responsiveness of T cells to LTD4induced by Der p. In allergic individuals, Der p also induced T cell proliferation and a Th2-biased phenotype. Our data suggest that, in allergen-sensitized individuals, exposure to allergen can enhance T cell expression of CysLT1receptors through a mechanism involving IL-4 production. This, in turn, would induce CD4+T cell responsiveness to cysteinyl-leukotrienes and Th2 cell activation.

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