The Association Study of Plasma Levels of Pigment Epithelium-Derived Factor with Acute Coronary Syndrome in the Chinese Han Population

Cardiology ◽  
2014 ◽  
Vol 127 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Jie Liu ◽  
Shuxia Wang ◽  
Jinxin Shi ◽  
Yuanyuan Guo ◽  
Jianfeng Liu ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Association Study ◽  
Plasma Levels ◽  
Pigment Epithelium ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Coronary Syndrome ◽  
Pigment Epithelium Derived Factor

scholarly journals A Case-Control Study between Gene Polymorphisms of Polyunsaturated Fatty Acid Metabolic Rate-Limiting Enzymes and Acute Coronary Syndrome in Chinese Han Population

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Zikai Song ◽  
Hongyan Cao ◽  
Ling Qin ◽  
Yanfang Jiang
Keyword(s):  
Acute Coronary Syndrome ◽  
Fatty Acid ◽  
Fatty Acid Desaturase ◽  
Chinese Han Population ◽  
Control Group ◽  
Allelic Association ◽  
Polymorphism Analysis ◽  
Chinese Han ◽  
Han Population ◽  
Coronary Syndrome

The purpose of this study is to analyze the relationship between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2), and elongation of very long-chain fatty acids-like 2 (ELOVL2) and acute coronary syndrome (ACS) in Chinese Han population. Therefore, we selected three single nucleotide polymorphisms (SNPs) from these candidate genes and genotyped them using PCR-based restriction fragment length polymorphism analysis in 249 ACS patients and 240 non-ACS subjects, as were Han Chinese ancestry. The results showed that rs174556 in theFADS1 gene is found to be in allelic association (P=0.003) and genotypic association (P=0.036) with ACS. The frequencies of rs174556 minor allele (T) in case group were obviously higher than in control group. The trans-phase gene-gene interaction analysis showed that the combined genotype of rs174556 (T/T) and rs3756963 (T/T) was associated with ACS (P=0.031). And the results suggest that, for rs174556 C>T, the CT/TT genotypes were more likely to lead in ACS in subjects with hypertension after correction of all risk factors (OR=4.236, 95% CI, 2.216–7.126). These findings suggest that the polymorphisms of rs174556 in theFADS1 gene are very likely to be associated with ACS in Chinese Han population, especially in subjects with hypertension.

scholarly journals MIF gene rs755622 polymorphism positively associated with acute coronary syndrome in Chinese Han population: case–control study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Guo-Li Du ◽  
Jun-Yi Luo ◽  
Duolao Wang ◽  
Yan-Hong Li ◽  
Bin-Bin Fang ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Multivariate Logistic Regression Analysis ◽  
Chinese Han Population ◽  
Healthy Controls ◽  
Chinese Han ◽  
Han Population ◽  
Coronary Syndrome ◽  
Increased Risk ◽  
Major Player ◽  
Control Study

AbstractMacrophage migration inhibitory factor (MIF) has been recognized as a major player in the pathogenesis of atherosclerosis. This study determined the association between polymorphisms of MIF gene and acute coronary syndrome (ACS). The polymorphism of MIF gene (rs755622, rs1007888 and rs2096525) was analyzed in 1153 healthy controls and 699 ACS cases in Chinese Han population. Plasma MIF level was also measured in part of ACS patients (139/19.9%) and healthy controls (129/11.2%) randomly. Most participants including healthy controls and ACS patients carried rs755622 GG (63.1% vs. 56.7%) and CG genotypes (33.1% vs. 38.9%) and G allele of rs755622 (79.6% vs. 76.1%, respectively), while CC genotype (3.8% vs. 4.4%) and C allele (20.4% vs. 23.9%) carriers were the lowest. Multivariate logistic regression analysis showed that carriers with rs755622 C allele had a higher risk of ACS compared to other genotypes (AOR = 1.278, 95% CI: 1.042–1.567). In addition, CC genotype carriers had the highest plasma levels of MIF than other genotype carriers. The MIF level in ACS patients with CC genotype was significantly higher than ACS patients carrying GG genotype and healthy controls carrying 3 different genotypes of MIF gene rs755622. Our findings indicate that MIF gene rs755622 variant C allele is associated with increased risk of ACS. Identification of this MIF gene polymorphism may help for predicting the risk of ACS.

scholarly journals Polymorphism of HDAC9 Gene Is Associated with Increased Risk of Acute Coronary Syndrome in Chinese Han Population

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Zhenhua Han ◽  
Xin Dong ◽  
Chaoying Zhang ◽  
Yue Wu ◽  
Zuyi Yuan ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Association Studies ◽  
Chinese Han Population ◽  
Control Group ◽  
Allele Carrier ◽  
Genome Wide Association Studies ◽  
Chinese Han ◽  
Han Population ◽  
Coronary Syndrome ◽  
Increased Risk

Recent genome-wide association studies (GWAS) have indicated an association of histone deacetylase 9 (HDAC9) genetic variant with large-vessel stroke and coronary artery disease, among the European population. However, whether HDAC9 gene is associated with an increased susceptibility to acute coronary syndrome (ACS) in Chinese Han population is not known. A total of 472 patients, including patients with ACS (N=309), and those with chest pain syndrome (controls,N=163) were enrolled. Genotyping for HDAC9 gene was performed using the ligation detection reaction assay. A series of statistical analyses were performed to investigate the correlation between HDAC9 gene SNPs and the susceptibility to ACS. The results revealed a significant association of rs2240419 with ACS risk in which the A allele (P= 0.047) and the A allele carriers (AA + AG) (P= 0.037) were more likely to be in ACS group as compared to those in the control group. None of two other SNPs, rs2389995 and rs2107595, were significantly associated with ACS risk (P> 0.05). Logistic regression analyses further revealed an increased risk for ACS in A allele carrier among rs2240419 genotypes, as compared to those with GG homozygotes (odds ratio: 1.869, 95% CI 1.143, 3.056,P= 0.013). A significant correlation between rs2240419 polymorphism of HDAC9 gene and the susceptibility to ACS in Chinese Han population was observed in this study.

Interleukin-8 gene polymorphism is associated with acute coronary syndrome in the Chinese Han population

Cytokine ◽  
2011 ◽  
Vol 56 (2) ◽  
pp. 188-191 ◽  
Author(s):  
Xiaolin Zhang ◽  
BaoHai Zhang ◽  
Mingxiang Zhang ◽  
Yaling Han ◽  
Yongwei Zhao ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Gene Polymorphism ◽  
Interleukin 8 ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Coronary Syndrome
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