scholarly journals Association of a transforming growth factor-β1 polymorphism with acute coronary syndrome in a Chinese Han population

2014 ◽  
Vol 13 (3) ◽  
pp. 6160-6167
Author(s):  
Y.N. Yang ◽  
B. Zhao ◽  
X.M. Li ◽  
X. Xie ◽  
F. Liu ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Coronary Syndrome

The T29C polymorphism of the transforming growth factor-β1 (TGF-β1) gene is associated with genetic susceptibility to acute coronary syndrome in Mexican patients

Cytokine ◽  
2012 ◽  
Vol 58 (3) ◽  
pp. 380-383 ◽  
Author(s):  
José Manuel Fragoso ◽  
Marco Antonio Martínez-Ríos ◽  
Edith Alvarez-León ◽  
Maite Vallejo ◽  
Marco Antonio Peña-Duque ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Growth Factor ◽  
Genetic Susceptibility ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Coronary Syndrome ◽  
Tgf Β1 ◽  
Mexican Patients

scholarly journals A Case-Control Study between Gene Polymorphisms of Polyunsaturated Fatty Acid Metabolic Rate-Limiting Enzymes and Acute Coronary Syndrome in Chinese Han Population

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Zikai Song ◽  
Hongyan Cao ◽  
Ling Qin ◽  
Yanfang Jiang
Keyword(s):  
Acute Coronary Syndrome ◽  
Fatty Acid ◽  
Fatty Acid Desaturase ◽  
Chinese Han Population ◽  
Control Group ◽  
Allelic Association ◽  
Polymorphism Analysis ◽  
Chinese Han ◽  
Han Population ◽  
Coronary Syndrome

The purpose of this study is to analyze the relationship between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2), and elongation of very long-chain fatty acids-like 2 (ELOVL2) and acute coronary syndrome (ACS) in Chinese Han population. Therefore, we selected three single nucleotide polymorphisms (SNPs) from these candidate genes and genotyped them using PCR-based restriction fragment length polymorphism analysis in 249 ACS patients and 240 non-ACS subjects, as were Han Chinese ancestry. The results showed that rs174556 in theFADS1 gene is found to be in allelic association (P=0.003) and genotypic association (P=0.036) with ACS. The frequencies of rs174556 minor allele (T) in case group were obviously higher than in control group. The trans-phase gene-gene interaction analysis showed that the combined genotype of rs174556 (T/T) and rs3756963 (T/T) was associated with ACS (P=0.031). And the results suggest that, for rs174556 C>T, the CT/TT genotypes were more likely to lead in ACS in subjects with hypertension after correction of all risk factors (OR=4.236, 95% CI, 2.216–7.126). These findings suggest that the polymorphisms of rs174556 in theFADS1 gene are very likely to be associated with ACS in Chinese Han population, especially in subjects with hypertension.

scholarly journals Association between transforming growth factor-beta 1 gene single nucleotide polymorphisms and knee osteoarthritis susceptibility in a Chinese Han population

2017 ◽  
Vol 45 (5) ◽  
pp. 1495-1504 ◽  
Author(s):  
Ning Lu ◽  
Jianwei Lu ◽  
Chenhe Zhou ◽  
FuHua Zhong
Keyword(s):  
Growth Factor ◽  
Knee Osteoarthritis ◽  
Transforming Growth Factor ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Knee Oa ◽  
Increased Risk ◽  
Gender And Age ◽  
Tgf Β1

Objective To investigate associations between single polymorphisms (SNPs) rs1800469 and rs1982073 in the transforming growth factor-β1 gene ( TGF-β1) and knee osteoarthritis (OA) susceptibility in a Chinese Han population. Methods TGF-β1 rs1800469 and rs1982073 were genotyped in patients with knee OA and age- and sex-matched OA-free controls from a Chinese Han population. The association was further analyzed according to gender and age. Results A total of 765 patients with knee OA and 780 controls were included. CT and CT + CC genotypes of rs1982073, and variant C, were associated with a significantly increased risk of knee OA. Stratification analysis showed that the association between the OA risk and rs1982073 CT heterozygotes compared with TT homozygotes was stronger in females and those aged >65 years. In contrast, CT, TT, and CT + TT genotypes of rs1800469 were not significantly associated with the risk of knee OA, even after further stratification analysis for gender and age. Conclusions The TGF-β1 rs1982073 T to C change and the variant C genotype may contribute to knee OA risk in the Chinese Han population.

scholarly journals MIF gene rs755622 polymorphism positively associated with acute coronary syndrome in Chinese Han population: case–control study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Guo-Li Du ◽  
Jun-Yi Luo ◽  
Duolao Wang ◽  
Yan-Hong Li ◽  
Bin-Bin Fang ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Multivariate Logistic Regression Analysis ◽  
Chinese Han Population ◽  
Healthy Controls ◽  
Chinese Han ◽  
Han Population ◽  
Coronary Syndrome ◽  
Increased Risk ◽  
Major Player ◽  
Control Study

AbstractMacrophage migration inhibitory factor (MIF) has been recognized as a major player in the pathogenesis of atherosclerosis. This study determined the association between polymorphisms of MIF gene and acute coronary syndrome (ACS). The polymorphism of MIF gene (rs755622, rs1007888 and rs2096525) was analyzed in 1153 healthy controls and 699 ACS cases in Chinese Han population. Plasma MIF level was also measured in part of ACS patients (139/19.9%) and healthy controls (129/11.2%) randomly. Most participants including healthy controls and ACS patients carried rs755622 GG (63.1% vs. 56.7%) and CG genotypes (33.1% vs. 38.9%) and G allele of rs755622 (79.6% vs. 76.1%, respectively), while CC genotype (3.8% vs. 4.4%) and C allele (20.4% vs. 23.9%) carriers were the lowest. Multivariate logistic regression analysis showed that carriers with rs755622 C allele had a higher risk of ACS compared to other genotypes (AOR = 1.278, 95% CI: 1.042–1.567). In addition, CC genotype carriers had the highest plasma levels of MIF than other genotype carriers. The MIF level in ACS patients with CC genotype was significantly higher than ACS patients carrying GG genotype and healthy controls carrying 3 different genotypes of MIF gene rs755622. Our findings indicate that MIF gene rs755622 variant C allele is associated with increased risk of ACS. Identification of this MIF gene polymorphism may help for predicting the risk of ACS.

scholarly journals Polymorphism of HDAC9 Gene Is Associated with Increased Risk of Acute Coronary Syndrome in Chinese Han Population

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Zhenhua Han ◽  
Xin Dong ◽  
Chaoying Zhang ◽  
Yue Wu ◽  
Zuyi Yuan ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Association Studies ◽  
Chinese Han Population ◽  
Control Group ◽  
Allele Carrier ◽  
Genome Wide Association Studies ◽  
Chinese Han ◽  
Han Population ◽  
Coronary Syndrome ◽  
Increased Risk

Recent genome-wide association studies (GWAS) have indicated an association of histone deacetylase 9 (HDAC9) genetic variant with large-vessel stroke and coronary artery disease, among the European population. However, whether HDAC9 gene is associated with an increased susceptibility to acute coronary syndrome (ACS) in Chinese Han population is not known. A total of 472 patients, including patients with ACS (N=309), and those with chest pain syndrome (controls,N=163) were enrolled. Genotyping for HDAC9 gene was performed using the ligation detection reaction assay. A series of statistical analyses were performed to investigate the correlation between HDAC9 gene SNPs and the susceptibility to ACS. The results revealed a significant association of rs2240419 with ACS risk in which the A allele (P= 0.047) and the A allele carriers (AA + AG) (P= 0.037) were more likely to be in ACS group as compared to those in the control group. None of two other SNPs, rs2389995 and rs2107595, were significantly associated with ACS risk (P> 0.05). Logistic regression analyses further revealed an increased risk for ACS in A allele carrier among rs2240419 genotypes, as compared to those with GG homozygotes (odds ratio: 1.869, 95% CI 1.143, 3.056,P= 0.013). A significant correlation between rs2240419 polymorphism of HDAC9 gene and the susceptibility to ACS in Chinese Han population was observed in this study.

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