Mineralocorticoid Receptor Blockade Reduced Oxidative Stress in Renal Transplant Recipients: A Double-Blind, Randomized Pilot Study

2013 ◽  
Vol 37 (5) ◽  
pp. 481-490 ◽  
Author(s):  
Marcos Ojeda-Cervantes ◽  
Jonatan Barrera-Chimal ◽  
Josefina Alberú ◽  
Rosalba Pérez-Villalva ◽  
Luis Eduardo Morales-Buenrostro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pilot Study ◽  
Renal Transplant ◽  
Mineralocorticoid Receptor ◽  
Renal Transplant Recipients ◽  
Receptor Blockade ◽  
Transplant Recipients ◽  
Double Blind ◽  
Mineralocorticoid Receptor Blockade

scholarly journals FP873IMMUNOGLOBULIN INDUCTION THERAPY IN RENAL TRANSPLANT RECIPIENTS - FIVE YEAR DATA OF A PROSPECTIVE RANDOMIZED PILOT STUDY

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii369-iii369 ◽  
Author(s):  
Rolf Weimer ◽  
Bogumila Bartylak ◽  
Anne Staak ◽  
Fabrice Renner ◽  
Caner Suesal ◽  
...  
Keyword(s):  
Pilot Study ◽  
Renal Transplant ◽  
Induction Therapy ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals A Multicenter Pilot Study of Early (4-Day) Steroid Cessation in Renal Transplant Recipients Under Simulect, Tacrolimus and Sirolimus

2005 ◽  
Vol 5 (1) ◽  
pp. 157-166 ◽  
Author(s):  
E. Steve Woodle ◽  
Flavio Vincenti ◽  
Marc I. Lorber ◽  
H. Albin Gritsch ◽  
Donald Hricik ◽  
...  
Keyword(s):  
Pilot Study ◽  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals SP798RELATIONS AMONG HYPERURICEMIA,INFLAMMATION, OXIDATIVE STRESS AND ARTERIAL STIFFNESS IN RENAL TRANSPLANT RECIPIENTS

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii641-iii642
Author(s):  
Bahar Gurlek Demirci ◽  
Mehtap Erkmen Uyar ◽  
Zeynep Bal ◽  
Emre Tutal ◽  
Fatma NurhanOzdemir Acar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Transplant ◽  
Arterial Stiffness ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Plasma Malondialdehyde and Risk of New-Onset Diabetes after Transplantation in Renal Transplant Recipients: A Prospective Cohort Study

2019 ◽  
Vol 8 (4) ◽  
pp. 453 ◽  
Author(s):  
Manuela Yepes-Calderón ◽  
Camilo Sotomayor ◽  
António Gomes-Neto ◽  
Rijk Gans ◽  
Stefan Berger ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Transplant ◽  
Cox Proportional Hazards ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Dietary Antioxidants ◽  
Onset Diabetes ◽  
Plasma Malondialdehyde ◽  
New Onset

New-onset diabetes after transplantation (NODAT) is a frequent complication in renal transplant recipients (RTR). Although oxidative stress has been associated with diabetes mellitus, data regarding NODAT are limited. We aimed to prospectively investigate the long-term association between the oxidative stress biomarker malondialdehyde (measured by high-performance liquid chromatography) and NODAT in an extensively phenotyped cohort of non-diabetic RTR with a functioning graft ≥1 year. We included 516 RTR (51 ± 13 years-old, 57% male). Median plasma malondialdehyde (MDA) was 2.55 (IQR, 1.92–3.66) µmol/L. During a median follow-up of 5.3 (IQR, 4.6–6.0) years, 56 (11%) RTR developed NODAT. In Cox proportional-hazards regression analyses, MDA was inversely associated with NODAT, independent of immunosuppressive therapy, transplant-specific covariates, lifestyle, inflammation, and metabolism parameters (HR, 0.55; 95% CI, 0.36–0.83 per 1-SD increase; p < 0.01). Dietary antioxidants intake (e.g., vitamin E, α-lipoic acid, and linoleic acid) were effect-modifiers of the association between MDA and NODAT, with particularly strong inverse associations within the subgroup of RTR with relatively higher dietary antioxidants intake. In conclusion, plasma MDA concentration is inversely and independently associated with long-term risk of NODAT in RTR. Our findings support a potential underrecognized role of oxidative stress in post-transplantation glucose homeostasis.

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