Discussion on One-Carbon Metabolism, Fetal Growth and Long-Term Consequences

2013 ◽  
pp. 139-144
Keyword(s):  
Fetal Growth ◽  
Carbon Metabolism ◽  
Long Term Consequences ◽  
One Carbon Metabolism

scholarly journals Long-Term, Supplemental, One-Carbon Metabolism–Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort

2017 ◽  
Vol 35 (30) ◽  
pp. 3440-3448 ◽  
Author(s):  
Theodore M. Brasky ◽  
Emily White ◽  
Chi-Ling Chen
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Carbon Metabolism ◽  
Lung Cancer Risk ◽  
Hazard Ratio ◽  
B Vitamins ◽  
Vitamin B ◽  
Supplement Use ◽  
One Carbon Metabolism

Purpose Inconsistent findings have been reported of a link between the use of one-carbon metabolism–related B vitamins and lung cancer risk. Because of the high prevalence of supplemental vitamin B use, any possible increased association warrants further investigation. We examined the association between long-term use of supplemental B vitamins on the one-carbon metabolism pathway and lung cancer risk in the Vitamins and Lifestyle (VITAL) cohort, which was designed specifically to look at supplement use relative to cancer risk. Methods A total of 77,118 participants of the VITAL cohort, 50 to 76 years of age, were recruited between October 2000 and December 2002 and included in this analysis. Incident, primary, invasive lung cancers (n = 808) were ascertained by prospectively linking the participants to a population-based cancer registry. The 10-year average daily dose from individual and multivitamin supplements were the exposures of primary interest. Results Use of supplemental vitamins B6, folate, and B12 was not associated with lung cancer risk among women. In contrast, use of vitamin B6 and B12 from individual supplement sources, but not from multivitamins, was associated with a 30% to 40% increase in lung cancer risk among men. When the 10-year average supplement dose was evaluated, there was an almost two-fold increase in lung cancer risk among men in the highest categories of vitamin B6 (> 20 mg/d; hazard ratio, 1.82; 95% CI, 1.25 to 2.65) and B12 (> 55µg/d; hazard ratio, 1.98; 95% CI, 1.32 to 2.97) compared with nonusers. For vitamin B6 and B12, the risk was even higher among men who were smoking at baseline. In addition, the B6 and B12 associations were apparent in all histologic types except adenocarcinoma, which is the type less related to smoking. Conclusion This sex- and source-specific association provides further evidence that vitamin B supplements are not chemopreventive for lung cancer and may be harmful.

B-Vitamine und Lungenkrebsrisiko

2017 ◽  
Vol 49 (04) ◽  
pp. 195-197
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Clin Oncol ◽  
Carbon Metabolism ◽  
Vitamin B6 ◽  
Lung Cancer Risk ◽  
Vitamin B ◽  
One Carbon Metabolism

Brasky TM, White E, Cheng C-L. Long-term, supplemental, one-carbon metabolism-related vitamin B use in relation to lung cancer risk in the Vitamins and Lifestyle (VITAL) Cohort. J Clin Oncol 2017; 35: 3440–3448 Die jahrelange Einnahme von hoch dosierten Vitamin-B6- oder -B12-Einzelpräparaten ging in einer prospektiven Kohortenstudie bei älteren Männern mit einem stark erhöhten Lungenkrebsrisiko (2- bis 4-fach) einher.

scholarly journals The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism

2013 ◽  
Vol 19 (6) ◽  
pp. 640-655 ◽  
Author(s):  
R. P. M. Steegers-Theunissen ◽  
J. Twigt ◽  
V. Pestinger ◽  
K. D. Sinclair
Keyword(s):  
Carbon Metabolism ◽  
Periconceptional Period ◽  
One Carbon Metabolism

scholarly journals Neonatal and Long-Term Consequences of Fetal Growth Restriction

2018 ◽  
Vol 14 (4) ◽  
pp. 212-218 ◽  
Author(s):  
Marina Colella ◽  
Alice Frérot ◽  
Aline Rideau Batista Novais ◽  
Olivier Baud
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Long Term Consequences

scholarly journals Association between Dietary Intake of One-Carbon Metabolism Nutrients in the Year before Pregnancy and Birth Anthropometry

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 838
Author(s):  
Marion Lecorguillé ◽  
Sandrine Lioret ◽  
Blandine de Lauzon-Guillain ◽  
Erwan de Gavelle ◽  
Anne Forhan ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Fetal Growth ◽  
Dietary Patterns ◽  
Carbon Metabolism ◽  
Nutrient Intake ◽  
Vitamin Supplementation ◽  
Reduced Rank Regression ◽  
Maternal Characteristics ◽  
Rank Regression ◽  
One Carbon Metabolism

Few studies have evaluated the role of methylation-pathway nutrients involved in fetal growth (B vitamins, choline, betaine, and methionine). These one-carbon metabolism (OCM) nutrients are essential for DNA methylation in the periconception period. We aimed to characterize dietary patterns of 1638 women from the EDEN mother-child cohort in the year before pregnancy according to the contribution of OCM nutrients and to study the association of such patterns with anthropometric measurements at birth. Dietary intake before pregnancy was assessed by using a semi-quantitative food frequency questionnaire. We used the reduced-rank regression (RRR) method to identify dietary patterns using OCM nutrients as intermediate variables. We ran linear regressions models to study the association between dietary patterns scores and birth weight, length, head circumference, gestational age, and sex-specific z-scores, adjusting for maternal characteristics and vitamin supplementation before and during pregnancy. Three patterns, “varied and balanced”, “vegetarian tendency”, and “bread and starchy food” were identified, explaining 58% of the variability in OCM nutrient intake. Higher scores on the “varied and balanced” pattern tended to be associated with higher birth length and weight. In mainly well-nourished young French women, we did not find evidence that variability in OCM nutrient intake has major effects on fetal growth.

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