scholarly journals The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism

2013 ◽  
Vol 19 (6) ◽  
pp. 640-655 ◽  
Author(s):  
R. P. M. Steegers-Theunissen ◽  
J. Twigt ◽  
V. Pestinger ◽  
K. D. Sinclair
Keyword(s):  
Carbon Metabolism ◽  
Periconceptional Period ◽  
One Carbon Metabolism

scholarly journals Long-Term, Supplemental, One-Carbon Metabolism–Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort

2017 ◽  
Vol 35 (30) ◽  
pp. 3440-3448 ◽  
Author(s):  
Theodore M. Brasky ◽  
Emily White ◽  
Chi-Ling Chen
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Carbon Metabolism ◽  
Lung Cancer Risk ◽  
Hazard Ratio ◽  
B Vitamins ◽  
Vitamin B ◽  
Supplement Use ◽  
One Carbon Metabolism

Purpose Inconsistent findings have been reported of a link between the use of one-carbon metabolism–related B vitamins and lung cancer risk. Because of the high prevalence of supplemental vitamin B use, any possible increased association warrants further investigation. We examined the association between long-term use of supplemental B vitamins on the one-carbon metabolism pathway and lung cancer risk in the Vitamins and Lifestyle (VITAL) cohort, which was designed specifically to look at supplement use relative to cancer risk. Methods A total of 77,118 participants of the VITAL cohort, 50 to 76 years of age, were recruited between October 2000 and December 2002 and included in this analysis. Incident, primary, invasive lung cancers (n = 808) were ascertained by prospectively linking the participants to a population-based cancer registry. The 10-year average daily dose from individual and multivitamin supplements were the exposures of primary interest. Results Use of supplemental vitamins B6, folate, and B12 was not associated with lung cancer risk among women. In contrast, use of vitamin B6 and B12 from individual supplement sources, but not from multivitamins, was associated with a 30% to 40% increase in lung cancer risk among men. When the 10-year average supplement dose was evaluated, there was an almost two-fold increase in lung cancer risk among men in the highest categories of vitamin B6 (> 20 mg/d; hazard ratio, 1.82; 95% CI, 1.25 to 2.65) and B12 (> 55µg/d; hazard ratio, 1.98; 95% CI, 1.32 to 2.97) compared with nonusers. For vitamin B6 and B12, the risk was even higher among men who were smoking at baseline. In addition, the B6 and B12 associations were apparent in all histologic types except adenocarcinoma, which is the type less related to smoking. Conclusion This sex- and source-specific association provides further evidence that vitamin B supplements are not chemopreventive for lung cancer and may be harmful.

scholarly journals Maternal One-carbon Metabolism during the Periconceptional Period and Human Foetal Brain Growth: A Systematic Review

Genes ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1634
Author(s):  
Eleonora Rubini ◽  
Inge M. M. Baijens ◽  
Alex Horánszky ◽  
Sam Schoenmakers ◽  
Kevin D. Sinclair ◽  
...  
Keyword(s):  
Carbon Metabolism ◽  
Growth And Development ◽  
Autism Spectrum ◽  
Head Size ◽  
Brain Growth ◽  
Foetal Head ◽  
Foetal Brain ◽  
Head Growth ◽  
Periconceptional Period ◽  
One Carbon Metabolism

The maternal environment during the periconceptional period influences foetal growth and development, in part, via epigenetic mechanisms moderated by one-carbon metabolic pathways. During embryonic development, one-carbon metabolism is involved in brain development and neural programming. Derangements in one-carbon metabolism increase (i) the short-term risk of embryonic neural tube-related defects and (ii) long-term childhood behaviour, cognition, and autism spectrum disorders. Here we investigate the association between maternal one-carbon metabolism and foetal and neonatal brain growth and development. Database searching resulted in 26 articles eligible for inclusion. Maternal vitamin B6, vitamin B12, homocysteine, and choline were not associated with foetal and/or neonatal head growth. First-trimester maternal plasma folate within the normal range (> 17 nmol/L) associated with increased foetal head size and head growth, and high erythrocyte folate (1538–1813 nmol/L) with increased cerebellar growth, whereas folate deficiency (< 7 nmol/L) associated with a reduced foetal brain volume. Preconceptional folic acid supplement use and specific dietary patterns (associated with increased B vitamins and low homocysteine) increased foetal head size. Although early pregnancy maternal folate appears to be the most independent predictor of foetal brain growth, there is insufficient data to confirm the link between maternal folate and offspring risks for neurodevelopmental diseases.

B-Vitamine und Lungenkrebsrisiko

2017 ◽  
Vol 49 (04) ◽  
pp. 195-197
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Clin Oncol ◽  
Carbon Metabolism ◽  
Vitamin B6 ◽  
Lung Cancer Risk ◽  
Vitamin B ◽  
One Carbon Metabolism

Brasky TM, White E, Cheng C-L. Long-term, supplemental, one-carbon metabolism-related vitamin B use in relation to lung cancer risk in the Vitamins and Lifestyle (VITAL) Cohort. J Clin Oncol 2017; 35: 3440–3448 Die jahrelange Einnahme von hoch dosierten Vitamin-B6- oder -B12-Einzelpräparaten ging in einer prospektiven Kohortenstudie bei älteren Männern mit einem stark erhöhten Lungenkrebsrisiko (2- bis 4-fach) einher.

Genetic Variation: Impact on Folate (and Choline) Bioefficacy

2010 ◽  
Vol 80 (45) ◽  
pp. 319-329 ◽  
Author(s):  
Allyson A. West ◽  
Marie A. Caudill
Keyword(s):  
Carbon Metabolism ◽  
Genetic Variants ◽  
Plasma Homocysteine ◽  
Water Soluble ◽  
Gene Interactions ◽  
Dietary Folate ◽  
Methyl Donors ◽  
Common Genetic Variants ◽  
One Carbon Metabolism ◽  
The Impact

Folate and choline are water-soluble micronutrients that serve as methyl donors in the conversion of homocysteine to methionine. Inadequacy of these nutrients can disturb one-carbon metabolism as evidenced by alterations in circulating folate and/or plasma homocysteine. Among common genetic variants that reside in genes regulating folate absorptive and metabolic processes, homozygosity for the MTHFR 677C > T variant has consistently been shown to have robust effects on status markers. This paper will review the impact of genetic variants in folate-metabolizing genes on folate and choline bioefficacy. Nutrient-gene and gene-gene interactions will be considered along with the need to account for these genetic variants when updating dietary folate and choline recommendations.

scholarly journals Effect of a Tailored Dietary Intervention with High or Standard Protein Intake on B-Vitamin and One Carbon Metabolism Status in Healthy Older Males: A 10 Week Randomised Controlled Trial

Proceedings ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 19
Author(s):  
Nicola Gillies ◽  
Amber M. Milan ◽  
Pankaja Sharma ◽  
Brenan Durainayagam ◽  
Sarah M. Mitchell ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Carbon Metabolism ◽  
Protein Intake ◽  
Dietary Intervention ◽  
Controlled Trial ◽  
One Carbon Metabolism ◽  
Randomised Controlled ◽  
B Vitamin ◽  
Standard Protein ◽  
Older Males

Background: Maintaining optimal status of folate and metabolically [...]

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